Research advances in the bile acid membrane receptor TGR5 in biliary tract diseases

Siping CHEN; Li HAN; Peng SHU; Xin DAI; Long CHENG

doi:10.3969/j.issn.1001-5256.2022.03.047

Volume 38 Issue 3

Mar. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(3): 724-728

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Research advances in the bile acid membrane receptor TGR5 in biliary tract diseases

DOI: 10.3969/j.issn.1001-5256.2022.03.047

Siping CHEN^{1, 2},
Li HAN^{1, 2},
Peng SHU²,
Xin DAI²,
Long CHENG^{2
,
,
,}

1.
Southwest Jiaotong University College of Medicine, Chengdu 610031, China
2.
General Surgery Center of PLA, The General Hospital of Western Theater Command, Chengdu 610083, China

Research funding:

The Youth Foundation of Science and Technology Department of Sichuan Province (2016JQ0023)

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Corresponding author: CHENG Long, tmmulong@163.com(ORCID: 0000-0002-0382-8212)
Received Date: 2021-07-21
Accepted Date: 2021-09-17
Published Date: 2022-03-20

Abstract

Abstract

TGR5 is a bile acid-activated G protein-coupled receptor and plays an important role in the physiological and pathological processes of the biliary system. This article describes the normal expression of TGR5 in the liver and bile duct under normal physiological conditions and its functions including the regulation of bile acid secretion and metabolism and cytoprotection. This article also summarizes the changes in the expression and function of TGR5 under pathophysiological conditions and the mechanism of TGR5 in affecting the development and progression of biliary tract diseases through inflammatory response and cell proliferation and apoptosis. TGR5 may be a potential target for the treatment of biliary tract diseases in the future.
- Biliary Tract Diseases,
- Cholic Acids,
- Receptors, G-Protein-Coupled

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References(41)

References

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Research advances in the bile acid membrane receptor TGR5 in biliary tract diseases

DOI: 10.3969/j.issn.1001-5256.2022.03.047

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Research advances in the bile acid membrane receptor TGR5 in biliary tract diseases

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