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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 8
Aug.  2022
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Article Contents

Functional cure of hepatitis B from the perspective of hepatitis B virus covalently closed circular DNA

DOI: 10.3969/j.issn.1001-5256.2022.08.003
Research funding:

National Natural Science Foundation of China (81861168035);

National Natural Science Foundation of China (81871656);

National Natural Science Foundation of China (81922011)

More Information
  • Corresponding author: HUANG Ailong, ahuang1964@163.com(ORCID: 0000-0003-0148-7423)
  • Received Date: 2022-06-02
  • Accepted Date: 2022-07-04
  • Published Date: 2022-08-20
  • Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the template for HBV transcription and replication and exists stably in hepatocytes in the form of minichromosome. Based on the mechanism of cccDNA inactivation or clearance and the development of related drugs, this article introduces the current knowledge on the formation, transcription, and degradation of cccDNA and reviews the research advances in cccDNA-targeted drugs and biological techniques.

     

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