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ISSN 2097-3497 (Online)
CN 22-1108/R
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2022 No.8
Theme Issue: Cure of chronic hepatitis B and clinical trial evaluation of investigational new drugs: From the perspective of basic research
Executive Chief Editor: LU Fengmin  
Peking University People’s Hospital
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Editorial
Urgent scientific issues to be solved in clinical trials of capsid assembly modulator combined with nucleos(t)ide analogues for the treatment of chronic hepatitis B
Fengmin LU, Hongxin HUANG, Tianhao MAO, Xiangmei CHEN, Hui ZHUANG
2022, 38(8): 1705-1709. DOI: 10.3969/j.issn.1001-5256.2022.08.001
Abstract(957) HTML (318) PDF (2576KB)(171)
Abstract:
Chronic hepatitis B virus (HBV) infection is the main cause of viral hepatitis, liver cirrhosis, and primary liver cancer. At present, nucleos(t)ide analogues (NUC) and pegylated interferon α used in clinical practice cannot directly target covalently closed circular DNA, and it is difficult to achi...
Discussions by Experts
Research advances in cytokines in the treatment of chronic hepatitis B
Zixiang GAO, Zhongliang SHEN, Jing LIU, Youhua XIE
2022, 38(8): 1710-1715. DOI: 10.3969/j.issn.1001-5256.2022.08.002
Abstract(1033) HTML (242) PDF (1905KB)(180)
Abstract:
At present, there are still about 250 million people with chronic hepatitis B virus (HBV) infection around the world, which seriously threatens human life and health. Chronic hepatitis B (CHB) can develop into liver diseases such as liver fibrosis, liver cirrhosis, and hepatocellular carcinoma; howe...
Functional cure of hepatitis B from the perspective of hepatitis B virus covalently closed circular DNA
Juan CHEN, Ailong HUANG
2022, 38(8): 1716-1720. DOI: 10.3969/j.issn.1001-5256.2022.08.003
Abstract(1095) HTML (479) PDF (1895KB)(265)
Abstract:
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the template for HBV transcription and replication and exists stably in hepatocytes in the form of minichromosome. Based on the mechanism of cccDNA inactivation or clearance and the development of related drugs, this article introduc...
Influencing factors for the functional cure of chronic hepatitis B and related mechanism
Yifei GUO, Jiming ZHANG
2022, 38(8): 1721-1725. DOI: 10.3969/j.issn.1001-5256.2022.08.004
Abstract(985) HTML (135) PDF (1897KB)(273)
Abstract:
Functional cure of chronic hepatitis B (CHB), defined as negative hepatitis B surface antigen (HBsAg) with or without the presence of hepatitis B surface antibody (anti-HBs), is considered the optimal endpoint for CHB treatment at present. Studies have shown that HBsAg clearance can reduce the risk ...
Mechanism of action, clinical research and development, and application prospect of hepatitis B virus core protein allosteric modulators
Hui LIU, Fengmin LU, Jutao GUO
2022, 38(8): 1726-1732. DOI: 10.3969/j.issn.1001-5256.2022.08.005
Abstract(1376) HTML (212) PDF (3109KB)(196)
Abstract:
Hepatitis B virus (HBV) infection is the main pathogenic factor for chronic hepatitis, and if it is not treated timely and effectively, it may have the risk of developing into end-stage liver diseases such as liver cirrhosis and hepatocellular carcinoma. Neither of the two types of antiviral drugs c...
Guidelines
Practice guidance for the use of terlipressin for liver cirrhosis related complications (2021)
Hepatobiliary Study Group of Chinese Society of Gastroenterology of Chinese Medical Association, Hepatology Committee of Chinese Research Hospital Association
2022, 38(8): 1733-1738. DOI: 10.3969/j.issn.1001-5256.2022.08.006
Abstract(1367) HTML (478) PDF (2431KB)(348)
Abstract:
Liver cirrhosis is a major global health burden worldwide due to its high risk of morbidity and mortality. Role of terlipressin for the management of liver cirrhosis related complications has been recognized during recent years. This paper aims to develop evidence-based clinical practice guidance on...
China guideline for liver cancer screening (2022, Beijing)
Jie HE, Wanqing CHEN, Hongbing SHEN, Ni LI, Chunfeng QU, Jufang SHI, Feng SUN, Jing JIANG, Guangwen CAO, Guihua ZHUANG, Ji PENG, Expert Panel of China Guideline for Liver Cancer Screening, Working Group of China Guideline for Liver Cancer Screening
2022, 38(8): 1739-1758. DOI: 10.3969/j.issn.1001-5256.2022.08.007
Abstract(4131) HTML (1138) PDF (2742KB)(1173)
Abstract:
In China, the survival rate of liver cancer remains low while the mortality rate is high. Effectively reducing the burden of liver cancer is still a major challenge in the field of public health and chronic disease prevention in the Chinese population. Optimizing screening strategies for liver cance...
Guideline Interpretation
Updated key points of chronic hepatitis B virus infection: developing drugs for treatment issued by the U.S. food and drug administration(clinical part)
Di SHA, Yidi WU, Junqi NIU, Meixia WANG
2022, 38(8): 1759-1762. DOI: 10.3969/j.issn.1001-5256.2022.08.008
Abstract(857) HTML (135) PDF (1883KB)(137)
Abstract:
In November 2018, the U.S. food and drug administration (FDA) issued guidance for the development of drugs for chronic hepatitis B virus infection (draft for comments) (hereinafter referred to as draft for comments), and in April 2022, the FDA issued Chronic Hepatitis B Virus Infection: Developing D...
Original Articles_Viral Hepatitis
Influence of intrahepatic cholestasis of pregnancy on adverse pregnancy outcomes of HBV-infected pregnant women
Xiali XIONG, Yunxia ZHU, Hong WEI, Zhiqiang ZHAO, Jun MENG, Huaibin ZOU, Zhongping DUAN
2022, 38(8): 1763-1767. DOI: 10.3969/j.issn.1001-5256.2022.08.009
Abstract(641) HTML (142) PDF (1899KB)(70)
Abstract:
Objective To investigate the influence of intrahepatic cholestasis of pregnancy (ICP) on adverse pregnancy outcomes of hepatitis B virus (HBV)-infected pregnant women. Methods A retrospective analysis was performed for 232 pregnant women with chronic HBV infection who were admitted to Beijing YouAn ...
Value of external validation of REAL-B score in predicting the risk of hepatocellular carcinoma in chronic hepatitis B patients treated by antiviral therapy
Xue WU, Weike CHU, Hui ZHOU, Bin NIU, Peng ZHANG, Jing FENG, Yuqiang MI, Ping LI
2022, 38(8): 1768-1773. DOI: 10.3969/j.issn.1001-5256.2022.08.010
Abstract(746) HTML (205) PDF (2834KB)(78)
Abstract:
Objective To investigate the value of the hepatocellular carcinoma (HCC) risk model REAL-B score in predicting the risk of HCC in chronic hepatitis B (CHB) patients receiving antiviral therapy in comparison with mPAGE-B, aMAP and PAGE-B scores. Methods A retrospective analysis was performed for the ...
Value of interleukin-6 combined with Model for End-Stage Liver Disease score in predicting the prognosis of hepatitis B virus-related acute-on-chronic liver failure
Yan WANG, Ying XU, Wei SUN, Li CHEN, Jianhe GAN, Jing GU
2022, 38(8): 1774-1779. DOI: 10.3969/j.issn.1001-5256.2022.08.011
Abstract(588) HTML (147) PDF (2320KB)(75)
Abstract:
Objective To investigate the value of interleukin-6 (IL-6) combined with Model for End-stage Liver Disease (MELD) score in predicting the prognosis of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (HBV-ACLF). Methods A total of 86 patients with HBV-ACLF who were hospit...
Original Articles_Fatty Liver Diseases
Effect of Huatan Qushi Huoxue prescription on the ultrastructure of hepatocyte mitochondria in rats with nonalcoholic steatohepatitis
Sutong LIU, Lihui ZHANG, Yajiao GU, Minghao LIU, Min GUO, Chenlu ZHAO, Wenxia ZHAO
2022, 38(8): 1780-1783. DOI: 10.3969/j.issn.1001-5256.2022.08.012
Abstract(703) HTML (316) PDF (2843KB)(61)
Abstract:
Objective To investigate the effect of Huatan Qushi Huoxue prescription on the ultrastructure of hepatocyte mitochondria in a rat model of nonalcoholic steatohepatitis (NASH). Methods A total of 48 male Sprague-Dawley rats were randomly divided into blank group, model group, Yishanfu group, and Huat...
Construction of Pnpla3 I148M and Tm6sf2 E167K double mutant mouse model
Mengke WANG, Shousheng LIU, Xueru CHU, Yifen WANG, Yongning XIN
2022, 38(8): 1784-1789. DOI: 10.3969/j.issn.1001-5256.2022.08.013
Abstract(1257) HTML (262) PDF (6045KB)(61)
Abstract:
Objective To construct a Pnpla3148M/M Tm6sf2167K/K double mutant mouse model by crossbreeding Pnpla3148M/M homozygous mice and Tm6sf2167K/K homozygous mice. Methods Pnpla3148I/M Tm6sf2167E/K heterozygous mice were bred by hybridization of Pnpla3148M/M Tm6sf2167E/E and Pnpla3148I/I Tm6sf2167K/K homoz...
Original Articles_Liver Fibrosis and Liver Cirrhosis
Establishment and validation of a noninvasive diagnostic model for chronic hepatitis B liver fibrosis based on LASSO regression
Jian ZHUANG, Weiwen ZHU, Chao ZHANG
2022, 38(8): 1790-1795. DOI: 10.3969/j.issn.1001-5256.2022.08.014
Abstract(961) HTML (218) PDF (3265KB)(81)
Abstract:
Objective To establish a noninvasive diagnostic model for chronic hepatitis B (CHB) liver fibrosis based on LASSO regression using serological parameters, and to investigate the value of this model in the diagnosis of CHB liver fibrosis. Methods A total of 240 patients who were diagnosed with CHB in...
Influencing factors for recompensation in patients with first-time decompensated hepatitis B cirrhosis
Jiajia RUAN, Shifei WEN, Xia WANG, Li LI, Juanjuan FU, Xiucheng PAN
2022, 38(8): 1796-1800. DOI: 10.3969/j.issn.1001-5256.2022.08.015
Abstract(739) HTML (261) PDF (2119KB)(132)
Abstract:
Objective To investigate the influencing factors for recompensation in patients with first-time decompensated hepatitis B cirrhosis. Methods A total of 438 patients with first-time decompensated hepatitis B cirrhosis who attended The Affiliated Hospital of Xuzhou Medical University from September 1,...
Risk factors for rebleeding after emergency esophageal variceal ligation in patients with liver cirrhosis
Qingjuan HE, Yingxia FANG, Xuchen LIU, Zhongbin LI
2022, 38(8): 1801-1805. DOI: 10.3969/j.issn.1001-5256.2022.08.016
Abstract(833) HTML (444) PDF (2091KB)(61)
Abstract:
Objective To investigate the risk factors for rebleeding after emergency esophageal variceal ligation (EVL) in patients with liver cirrhosis. Methods A retrospective analysis was performed for the clinical and laboratory data of 290 patients with liver cirrhosis who underwent emergency EVL in The Fi...
Features of anemia in patients with alcoholic liver cirrhosis
Xu YAN, Wenjing WANG, Dantong ZHAO
2022, 38(8): 1806-1812. DOI: 10.3969/j.issn.1001-5256.2022.08.017
Abstract(668) HTML (406) PDF (2081KB)(86)
Abstract:
Objective To investigate the laboratory and clinical features of anemia in patients with alcoholic liver cirrhosis. Methods A retrospective analysis was performed for the patients who were hospitalized in Beijing YouAn Hospital, Capital Medical University, from December 2020 to May 2021 and were fou...
Original Articles_Liver Neoplasms
Efficacy and safety of lenvatinib combined with sintilimab as the second-line therapy for intrahepatic cholangiocarcinoma
Xiaoyan DING, Wei SUN, Yanjun SHEN, Ying TENG, Yawen XU, Wendong LI, Jinglong CHEN
2022, 38(8): 1813-1818. DOI: 10.3969/j.issn.1001-5256.2022.08.018
Abstract(1395) HTML (1009) PDF (2697KB)(126)
Abstract:
Objective To investigate the efficacy and safety of lenvatinib combined with sintilimab as the second-line therapy for advanced intrahepatic cholangiocarcinoma (ICC). Methods A retrospective analysis was performed for the clinical data of the patients with advanced ICC who were admitted to Beijing D...
Effect of naringenin on natural killer cell cytotoxicity against hepatocellular carcinoma cells in vitro and its mechanism
Lijie MA, Chang YU, Fang WANG, Yifei TANG, Hailong WU, Xuehua SUN, Yueqiu GAO
2022, 38(8): 1819-1824. DOI: 10.3969/j.issn.1001-5256.2022.08.019
Abstract(636) HTML (152) PDF (3514KB)(64)
Abstract:
Objective To investigate the effect of naringenin on the killing rate of natural killer (NK) cells and related mechanism by amplification of human peripheral blood mononuclear cells into NK cells in vitro and co-culture with hepatocellular carcinoma (HCC) CLC5 cells at a ratio of 1∶ 1. Methods A lym...
A bioinformatics analysis of P2RY8 expression in hepatocellular carcinoma and its clinical significance
Ruqi MEI, Qian JU, Yueping LI, Chengcong LIU
2022, 38(8): 1825-1833. DOI: 10.3969/j.issn.1001-5256.2022.08.020
Abstract(771) HTML (226) PDF (5237KB)(82)
Abstract:
Objective To investigate the application value of the human B cell-confinement receptor P2RY8 in the diagnosis and prognosis of hepatocellular carcinoma (HCC) and its association with tumor immunity. Methods The Cancer Genome Atlas database was used to compare the expression of P2RY8. R software pac...
Original Articles_Other Liver Diseases
Identification and analysis of the risk of liver-related adverse drug reaction in pregnant women
Guangdi MU, Jiayi LI, Yunjuan GAO, Xu ZHAO, Jiabo WANG, Zhaofang BAI, Xiaohe XIAO, Yuming GUO
2022, 38(8): 1834-1838. DOI: 10.3969/j.issn.1001-5256.2022.08.021
Abstract(811) HTML (190) PDF (2634KB)(83)
Abstract:
Objective To investigate the potential medication risk by identifying and analyzing the features of liver-related adverse drug reaction (ADR) in pregnant women. Methods A retrospective study was performed for the reports on liver-related ADR in pregnant women from January 1, 2012 to December 31, 201...
Clinical and pathological features of children with glycogen storage disease: An analysis of 10 cases
Suxian ZHAO, Shiheng LIU, Wencong LI, Fang HAN, Shuhong LIU, Qingshan ZHANG, Weiguang REN, Lingbo KONG, Na FU, Rongqi WANG, Li KONG, Yuemin NAN, Jingmin ZHAO
2022, 38(8): 1839-1842. DOI: 10.3969/j.issn.1001-5256.2022.08.022
Abstract(890) HTML (230) PDF (2394KB)(73)
Abstract:
Objective To investigate the clinical and pathological features of children with glycogen storage disease (GSD). Methods A retrospective analysis was performed for ten children with GSD who were admitted to the Third Hospital of Hebei Medical University and The Fifth Medical Center of Chinese PLA Ge...
Clinical features of Wilson's disease: An analysis of 83 cases
Lei JI, Ying ZHANG, Li KONG, Suxian ZHAO, Po CUI, Qingshan ZHANG, Lingbo KONG, Weiguang REN
2022, 38(8): 1843-1846. DOI: 10.3969/j.issn.1001-5256.2022.08.023
Abstract(949) HTML (161) PDF (1880KB)(90)
Abstract:
Objective To summarize the clinical features of patients with Wilson's disease (WD). Methods A retrospective analysis was performed for the clinical data of 83 patients with WD who were admitted to The Third Hospital of Hebei Medical University from April 2013 to August 2021, including clinical mani...
Original Articles_Biliary Diseases
A multivariate analysis of acute severe cholangitis and the establishment and evaluation of a risk prediction scoring model
Hongyu XIANG, Zheng DANG, Shulin XU, Gang NIU, Yuesheng LI, Baiwen MIAO, Yaoping PANG, Ruifang FAN, Jianwei QIN
2022, 38(8): 1847-1853. DOI: 10.3969/j.issn.1001-5256.2022.08.024
Abstract(598) HTML (124) PDF (2651KB)(61)
Abstract:
Objective To investigate the independent risk factors for acute severe cholangitis and related protective factors, and to construct a risk prediction scoring model for acute severe cholangitis. Methods A retrospective analysis was performed for the clinical data of 381 patients with acute cholangiti...
Efficacy of endoscopic retrograde cholangiopancreatography combined with SpyGlass system in treatment of acute cholecystitis secondary to choledocholithiasis
Liying TAO, Hongguang WANG, Xiang GUO, Jian ZHOU, Qingmei GUO, Mantong WANG
2022, 38(8): 1854-1858. DOI: 10.3969/j.issn.1001-5256.2022.08.025
Abstract(835) HTML (216) PDF (2754KB)(50)
Abstract:
Objective To investigate the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP)+SpyGlass system versus percutaneous transhepatic gallbladder drainage (PTGD)+ERCP in the treatment of acute cholecystitis secondary to choledocholithiasis. Methods A retrospective analysis was p...
Association between gallstones and metabolic syndrome in southern Xinjiang, China
Xiaoyong DUO, Shijie ZHANG, Hongwei ZHANG, Jing YANG, Wenqiang WANG, Linzhi YU, Baocai ZHANG, Yicheng ZHUO, Yunchao JIA, Yan PENG, Shuai HU
2022, 38(8): 1859-1864. DOI: 10.3969/j.issn.1001-5256.2022.08.026
Abstract(521) HTML (125) PDF (1899KB)(28)
Abstract:
Objective To investigate the association between gallstones (GS) and metabolic syndrome (MS) in southern Xinjiang, China, and to provide experience for the prevention and control of metabolic diseases in southern Xinjiang. Methods The patients with GS who visited First Division Hospital, Second Divi...
Original Articles_Pancreatic Diseases
Pathogenesis and prognosis of tumor-induced acute pancreatitis: An analysis of 84 cases
Linlin ZHENG, Hui HE, Xiaohua KONG, Yunhui ZHOU, Ningning LIU, Lin ZHOU
2022, 38(8): 1865-1871. DOI: 10.3969/j.issn.1001-5256.2022.08.027
Abstract(489) HTML (132) PDF (1935KB)(48)
Abstract:
Objective To investigate the association of biliary, pancreatic, and ampullary tumors with the onset of acute pancreatitis (AP) and the clinical features of tumor-induced AP by retrospectively analyzing the clinical data of patients with tumor-induced AP. Methods Related clinical data were collected...
Case Reports
Hepatocellular carcinoma with bile duct tumor thrombus: A case report
Renjie LU, Fangfang SUN, Jie DU, Lirong ZHAO
2022, 38(8): 1872-1874. DOI: 10.3969/j.issn.1001-5256.2022.08.028
Abstract(464) HTML (256) PDF (3665KB)(60)
Abstract:
Late-onset diaphragmatic hernia after microwave ablation of hepatocellular carcinoma: A case report
Xiaodong WANG, Yurong ZHANG, Xiaoning ZHU, Ding ZHENG, Jing WANG
2022, 38(8): 1875-1877. DOI: 10.3969/j.issn.1001-5256.2022.08.029
Abstract(459) HTML (218) PDF (2572KB)(39)
Abstract:
Schwannoma of the pancreatic tail: A case report
Jiachao ZHANG, Rong TANG, Zhensheng ZHANG, Pingping CHEN, Yongchao ZENG
2022, 38(8): 1878-1879. DOI: 10.3969/j.issn.1001-5256.2022.08.030
Abstract(352) HTML (155) PDF (3067KB)(42)
Abstract:
Hepatosplenomegaly with β-lipoprotein deficiency: A case report
Haijun GUO
2022, 38(8): 1880-1882. DOI: 10.3969/j.issn.1001-5256.2022.08.031
Abstract(412) HTML (152) PDF (2351KB)(49)
Abstract:
A case of systemic light-chain amyloidosis with fatal spontaneous splenic rupture
Duo LI, Yingren ZHAO, Hongmei CHEN
2022, 38(8): 1883-1885. DOI: 10.3969/j.issn.1001-5256.2022.08.032
Abstract(423) HTML (159) PDF (2823KB)(36)
Abstract:
Reviews
Role of traditional Chinese medicine in treatment of chronic hepatitis B by nucleos(t)ide analogues
Hanxiao WANG, Xinju CHEN, Qing ZHAO, Wenxia ZHAO
2022, 38(8): 1886-1891. DOI: 10.3969/j.issn.1001-5256.2022.08.033
Abstract(709) HTML (178) PDF (2126KB)(108)
Abstract:
Nucleos(t)ide analogues (NUC) can inhibit the replication of hepatitis B virus (HBV) and effectively treat chronic hepatitis B (CHB), but they cannot completely eradicate HBV and cannot prevent the progression to hepatitis B cirrhosis and liver cancer in the context of a low viral load. In recent ye...
Management of autoimmune hepatitis during prepregnancey-pregnancy-postpartum
Chunyan LI, Wenjiao XU, Limei SHAO, Shanhong TANG
2022, 38(8): 1892-1895. DOI: 10.3969/j.issn.1001-5256.2022.08.034
Abstract(849) HTML (307) PDF (1874KB)(105)
Abstract:
Autoimmune hepatitis (AIH) is a chronic progressive inflammatory disease of the liver caused by the attack of liver cells by the autoimmune system, with the features of positive serum autoantibodies, high IgG, and/or γ-globulinemia. Current studies on pregnancy in patients with AIH mainly focus on l...
Research advances in exosomes in primary biliary cholangitis
Haitao MA, Yingmei TANG
2022, 38(8): 1896-1900. DOI: 10.3969/j.issn.1001-5256.2022.08.035
Abstract(832) HTML (162) PDF (2269KB)(83)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by cholestasis. In recent years, a number of studies in China and globally have shown that exosomes play an important role in the development and progression of PBC, which is currently a hotspot in the field of medical re...
Research advances in the treatment of portal vein thrombosis and gastrointestinal bleeding in patients with liver cirrhosis
Yan SHEN, Xin CHEN, Tao WU, Lin CHEN
2022, 38(8): 1901-1905. DOI: 10.3969/j.issn.1001-5256.2022.08.036
Abstract(654) HTML (308) PDF (1890KB)(90)
Abstract:
Portal vein thrombosis (PVT) in patients with liver cirrhosis has attracted more and more attention in recent years, and it can increase portal venous pressure in patients with liver cirrhosis, aggravate esophageal and gastric varices, and even lead to rupture and bleeding. This article reviews the ...
Research advances in nano-drug delivery system in liver cancer treatment
Miaodong WANG, Zeshan CHEN, Peichun PENG, Xin DENG
2022, 38(8): 1906-1912. DOI: 10.3969/j.issn.1001-5256.2022.08.037
Abstract(1014) HTML (215) PDF (2076KB)(104)
Abstract:
Traditional surgical resection, radiotherapy, and chemotherapy still play a dominant role in the treatment of liver cancer; however, their application in liver cancer patients is often limited by the toxic and side effects, unstable efficacy, and unclear targets of chemotherapeutic drugs. Therefore,...
Current status of the research on microenvironment-targeting therapy and immunotherapy for liver cancer
Mingqiang ZHU, Youming DING
2022, 38(8): 1913-1917. DOI: 10.3969/j.issn.1001-5256.2022.08.038
Abstract(852) HTML (328) PDF (1898KB)(111)
Abstract:
Tumor microenvironment is composed of tumor cells and their internal and external environment, and the components vary slightly between different types of tumor. Liver cancer microenvironment is a tumor-promoting microenvironment constructed by hepatoma cells and immune cells and can lead to the dev...
Role of transcription factor Yin Yang 1 in hepatocellular carcinoma
Jie ZHOU, Yunhao HUA, Xiaomei WANG, Junqi NIU
2022, 38(8): 1918-1922. DOI: 10.3969/j.issn.1001-5256.2022.08.039
Abstract(786) HTML (477) PDF (3288KB)(59)
Abstract:
Hepatocellular carcinoma (HCC) often has an insidious onset, and most patients are in the advanced stage and have lost the best opportunity for treatment at the time of diagnosis, resulting in a poor prognosis. As a multifunctional transcription factor, Yin Yang 1 (YY1) regulates the transcription o...
Prevention and treatment of indirect drug-induced liver toxicity
Jinsheng GUO
2022, 38(8): 1923-1926. DOI: 10.3969/j.issn.1001-5256.2022.08.040
Abstract(642) HTML (223) PDF (1873KB)(81)
Abstract:
Indirect drug-induced liver toxicity (IDLT) refers to the condition that the use of some therapeutic drugs may induce new liver diseases or exacerbate the original liver disease, with the phenotype of underlying or predisposed liver diseases. IDLT may induce persistent liver injury or even acute liv...
Research advances in the role of inflammatory response and related treatment strategies in acute-on-chronic liver failure
Huaqian XU, Xue LI, Shanhong TANG
2022, 38(8): 1927-1930. DOI: 10.3969/j.issn.1001-5256.2022.08.041
Abstract(816) HTML (127) PDF (1872KB)(89)
Abstract:
Acute-on-chronic liver failure (ACLF) is a clinical syndrome with rapid deterioration of liver function caused by a series of predisposing factors on the basis of chronic liver diseases, and it is characterized by multiple organ failure and high short-term mortality. The onset of systemic inflammati...
Association between glycolysis and mitochondrial dysfunction and its potential value in liver diseases
Gengjie YAN, Yong LIN, Huiji SU, Hanxiao CHEN, Shaoqun BAN, Ailing WEI, Dewen MAO, Fuli LONG
2022, 38(8): 1931-1936. DOI: 10.3969/j.issn.1001-5256.2022.08.042
Abstract(1767) HTML (1399) PDF (2522KB)(171)
Abstract:
Glycolysis plays an important role in the development and progression of liver diseases and shows varying degrees of enhancement in different liver diseases, and it is closely associated with mitochondrial dysfunction (oxidative phosphorylation deficiency and reactive oxygen species production), whi...
Research advances in glucose and lipid metabolism disorders in different types of chronic liver diseases
Qian WANG, Chenrui ZHANG, Yingmei TANG
2022, 38(8): 1937-1940. DOI: 10.3969/j.issn.1001-5256.2022.08.043
Abstract(538) HTML (161) PDF (1883KB)(64)
Abstract:
The liver is an important metabolic organ in the body. Studies have shown that chronic liver disease is closely associated with glucose and lipid metabolism disorders, and different types of liver diseases often show different characteristics of glucose and lipid metabolism. This article reviews the...
Advances in endoscopic therapy for benign distal biliary strictures
Jinjie XU, Honglei GUO, Lianghao HU
2022, 38(8): 1941-1944. DOI: 10.3969/j.issn.1001-5256.2022.08.044
Abstract(705) HTML (188) PDF (2029KB)(61)
Abstract:
Benign distal biliary strictures (BDBS) are fibrous tissue proliferation and biliary stricture caused by long-term stimulation of the affected bile ducts due to non-neoplastic factors such as iatrogenic injury, chronic inflammation, and bile duct stones, which further leads to recurrent cholangitis,...
Introduction of High-quality Articles in Foreign Journals
Journal of Viral Hepatitis｜Serum HBV RNA predicts HBeAg clearance and seroconversion in patients with chronic hepatitis B treated with nucleos(t)ide analogues
2022, 38(8): 1882-1882. DOI: 10.3969/j.issn.1001-5256.2022.08.gwjpwzjj1
Abstract(299) HTML (254) PDF (852KB)(61)
Abstract:
Hepatology｜Macrophage-specific fibroblast growth factor 12 promotes liver fibrosis progression in mice
2022, 38(8): 1885-1885. DOI: 10.3969/j.issn.1001-5256.2022.08.gwjpwzjj2
Abstract(397) HTML (241) PDF (841KB)(58)
Abstract:
Thanks
Current reviewers
2022, 38(8): 1891-1891. DOI: 10.3969/j.issn.1001-5256.2022.08.zhixie1
Abstract(361) HTML (116) PDF (834KB)(58)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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