Prevention and treatment of indirect drug-induced liver toxicity

Jinsheng GUO

doi:10.3969/j.issn.1001-5256.2022.08.040

Volume 38 Issue 8

Aug. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(8): 1923-1926

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Prevention and treatment of indirect drug-induced liver toxicity

DOI: 10.3969/j.issn.1001-5256.2022.08.040

Jinsheng GUO^{,
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Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai Institute of Liver Diseases, Shanghai 200032, China

Research funding:

National Natural Science Foundation of China (91129705);

National Natural Science Foundation of China (81070340);

National Natural Science Foundation of China (30570825)

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Corresponding author: GUO Jinsheng, guo.jinsheng@zs-hospital.sh.cn(ORCID: 0000-0002-9980-8725)
Received Date: 2022-02-21
Accepted Date: 2022-03-22
Published Date: 2022-08-20

Abstract

Abstract

Indirect drug-induced liver toxicity (IDLT) refers to the condition that the use of some therapeutic drugs may induce new liver diseases or exacerbate the original liver disease, with the phenotype of underlying or predisposed liver diseases. IDLT may induce persistent liver injury or even acute liver failure and affect the pharmacotherapy for tumor or other comorbidities, leading to the suspension or termination of ongoing chemotherapy, immunotherapy, and targeted therapy, and therefore, it should be taken seriously in clinical practice. This article elaborates on the mechanisms and prevention strategies of several types of IDLT.
- Chemical and Drug Induced Liver Injury,
- Indirect Drug-Induced Liver Injury,
- Therapeutics

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Prevention and treatment of indirect drug-induced liver toxicity

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