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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 9
Sep.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(9): 2125-2129

Mechanism of action of exosomes in the development and progression of hepatitis B virus-related chronic hepatitis and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.09.034
  • 1.

    Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

  • 2.

    The First Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100029, China

Research funding:

National Science and Technology Major Project '13th Five-Year' (2018ZX10725505);

National Natural Science Foundation of China Youth Science Fund Project (81804033)

More Information
  • Corresponding author: LI Xiaoke, lixiaoke@vip.163.com(ORCID: 0000-0002-1775-3063); YE Yongan, yeyongan@vip.163.com(ORCID: 0000-0001-9765-4665)
  • Received Date: 2022-01-13
  • Accepted Date: 2022-02-17
  • Published Date: 2022-09-20
    Abstract
  • Exosomes (EXOs) are formed by intracellular multivesicular bodies and carry a variety of biomacromolecules such as lipids, proteins, encoding and non-coding RNAs, and mitochondrial DNA. EXOs can be released in vivo by different cell types, including hepatocytes, hepatic stellate cells, and immune cells and play the role of intercellular communication. More and more studies have shown that EXOs are involved in the development, progression, and prognosis of chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) infection and are expected to become potential biomarkers for the early diagnosis and prognostic evaluation of HBV-related HCC. This article reviews the role of EXOs in the host infection process of HBV and the importance of EXOs in the development, progression, and prognosis of CHB and HCC, in order to provide new ideas for the basic and clinical research in this field.

     

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