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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 10
Oct.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(10): 2201-2205

Development and progress of liver xenotransplantation: A potential breakthrough for current shortage of donor liver

DOI: 10.3969/j.issn.1001-5256.2022.10.001

  • Department of Hepato-Biliary Surgery and Army Institute of Organ Transplantation, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, China

Research funding:

National Natural Science Foundation of China (82070681);

National Natural Science Foundation of China (82170667);

National Natural Science Foundation of China (82070671);

National Natural Science Foundation of China (81970566);

Shaanxi Natural Science Basic Research Project (2022JM-537);

Xijing Hospital Discipline Assistance Program Supporting Project (XJZT21CM14);

Medical Research Project (AKJ19J001);

Medical Research Project (18CXZ014)

More Information
  • Corresponding author: DOU Kefeng, doukef@fmmu.edu.cn(ORCID: 0000-0002-8857-5663)
  • Received Date: 2022-08-01
  • Accepted Date: 2022-08-31
  • Published Date: 2022-10-20
    Abstract
  • The donor liver shortage is the bottles-neck limitation for clinical liver transplantation to save patients' life. Liver transplantation is a treatment option for end-stage liver diseases, like Cirrhosis and hepatocellular carcinoma, and acute liver failure; however, due to availability of donor liver, lots of patients never received such treatment option and passed way. Most recently, non-human primates after a liver transplantation with GTKO pigs survived for nearly 1 month indicates a promise of clinical use of liver xenotransplantation and could offer "a bridge transplantation" for fulminant liver failure patients. This review discussed and summarized the advancement and progress in the field, i.e., history of liver xenotransplantation research, model animals, clinical selection criteria, and future research directions and clinical trials.

     

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    • References(20)
  • [1]
    MONTGOMERY RA, STERN JM, LONZE BE, et al. Results of two cases of pig-to-human kidney xenotransplantation[J]. N Engl J Med, 2022, 386(20): 1889-1898. DOI: 10.1056/NEJMoa2120238.
    [2]
    BENDER M, LÄNGIN M, REICHART B, et al. Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations - particular in regard of the mandatory use of heart-lung machines[J]. Xenotransplantation, 2022, 29(3): e12749. DOI: 10.1111/xen.12749.
    [3]
    PIERSON RN 3rd. Progress toward pig-to-human xenotransplantation[J]. N Engl J Med, 2022, 386(20): 1871-1873. DOI: 10.1056/NEJMp2118019.
    [4]
    KOZLOV M. Clinical trials for pig-to-human organ transplants inch closer[J]. Nature, 2022, 607(7918): 223-224. DOI: 10.1038/d41586-022-01861-2.
    [5]
    SHAH JA, PATEL MS, ELIAS N, et al. Prolonged survival following pig-to-primate liver xenotransplantation utilizing exogenous coagulation factors and costimulation blockade[J]. Am J Transplant, 2017, 17(8): 2178-2185. DOI: 10.1111/ajt.14341.
    [6]
    NIU D, WEI HJ, LIN L, et al. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9[J]. Science, 2017, 357(6357): 1303-1307. DOI: 10.1126/science.aan4187.
    [7]
    KIM SC, MATHEWS DV, BREEDEN CP, et al. Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion[J]. Am J Transplant, 2019, 19(8): 2174-2185. DOI: 10.1111/ajt.15329.
    [8]
    LÄNGIN M, MAYR T, REICHART B, et al. Consistent success in life-supporting porcine cardiac xenotransplantation[J]. Nature, 2018, 564(7736): 430-433. DOI: 10.1038/s41586-018-0765-z.
    [9]
    LI X, WANG Y, YANG H, et al. Liver and hepatocyte transplantation: what can pigs contribute?[J]. Front Immunol, 2021, 12: 802692. DOI: 10.3389/fimmu.2021.802692.
    [10]
    EKSER B, LONG C, ECHEVERRI GJ, et al. Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance[J]. Am J Transplant, 2010, 10(2): 273-285. DOI: 10.1111/j.1600-6143.2009.02945.x.
    [11]
    EZZELARAB M, EKSER B, GRIDELLI B, et al. Thrombocytopenia after pig-to-baboon liver xenotransplantation: where do platelets go?[J]. Xenotransplantation, 2011, 18(6): 320-327. DOI: 10.1111/j.1399-3089.2011.00679.x.
    [12]
    CROSS-NAJAFI AA, LOPEZ K, ISIDAN A, et al. Current barriers to clinical liver xenotransplantation[J]. Front Immunol, 2022, 13: 827535. DOI: 10.3389/fimmu.2022.827535.
    [13]
    JI H, LI X, YUE S, et al. Pig BMSCs transfected with human TFPI combat species incompatibility and regulate the human TF pathway in vitro and in a rodent model[J]. Cell Physiol Biochem, 2015, 36(1): 233-249. DOI: 10.1159/000374067.
    [14]
    ZHANG Z, LI X, ZHANG H, et al. Cytokine profiles in Tibetan macaques following α-1,3-galactosyltransferase-knockout pig liver xenotransplantation[J]. Xenotransplantation, 2017, 24(5): e12321. DOI: 10.1111/xen.12321.
    [15]
    YEH H, MACHAIDZE Z, WAMALA I, et al. Increased transfusion-free survival following auxiliary pig liver xenotransplantation[J]. Xenotransplantation, 2014, 21(5): 454-464. DOI: 10.1111/xen.12111.
    [16]
    SHAH JA, NAVARRO-ALVAREZ N, DEFAZIO M, et al. A bridge to somewhere: 25-day survival after pig-to-baboon liver xenotransplantation[J]. Ann Surg, 2016, 263(6): 1069-1071. DOI: 10.1097/SLA.0000000000001659.
    [17]
    ZHANG X, WANG Q, ZHAO J, et al. The resurgent landscape of xenotransplantation of pig organs in nonhuman primates[J]. Sci China Life Sci, 2021, 64(5): 697-708. DOI: 10.1007/s11427-019-1806-2.
    [18]
    HORSLEN SP, HAMMEL JM, FRISTOE LW, et al. Extracorporeal liver perfusion using human and pig livers for acute liver failure[J]. Transplantation, 2000, 70(10): 1472-1478. DOI: 10.1097/00007890-200011270-00014.
    [19]
    LAMM V, EKSER B, VAGEFI PA, et al. Bridging to allotransplantation-is pig liver xenotransplantation the best option?[J]. Transplantation, 2022, 106(1): 26-36. DOI: 10.1097/TP.0000000000003722.
    [20]
    Group of Organ Transplantation Branch of Chinese Medical Association. Clinical research guidance for xenotransplantation (2018 recommended edition)[J]. Ogran Transplant, 2018, 9(6): 405-408. DOI: 10.3969/j.issn.1674-7445.2018.06.001.

    中华医学会器官移植学分会异种移植学组. 异种移植临床研究指导意见(2018建议版)[J]. 器官移植. 2018, 9(6): 405-408. DOI: 10.3969/j.issn.1674-7445.2018.06.001.
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