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ISSN 2097-3497 (Online)
CN 22-1108/R
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2022 No.10
Theme Issue: Development and Innovation of Xenogeneic Liver Transplantation
Executive Chief Editor: DOU Kefeng  
Air Force Military Medical University
Cover Content

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Editorial
Development and progress of liver xenotransplantation: A potential breakthrough for current shortage of donor liver
Xiao LI, Kefeng DOU
2022, 38(10): 2201-2205. DOI: 10.3969/j.issn.1001-5256.2022.10.001
Abstract(842) HTML (204) PDF (1836KB)(140)
Abstract:
The donor liver shortage is the bottles-neck limitation for clinical liver transplantation to save patients' life. Liver transplantation is a treatment option for end-stage liver diseases, like Cirrhosis and hepatocellular carcinoma, and acute liver failure; however, due to availability of donor liv...
Discussions by Experts
Liver xenotransplantation techniques: Characteristics and difficulties
Xiao LI, Kaishan TAO
2022, 38(10): 2206-2209. DOI: 10.3969/j.issn.1001-5256.2022.10.002
Abstract(853) HTML (160) PDF (1788KB)(132)
Abstract:
The rapid development of gene editing technology showed usefulness of pig xenotransplantation as a donor in clinical application. Clinical trials of non-human primates using pig heart and kidney were able to survive them for a long period of time, while the longest survival of xenograft liver transp...
Acute humoral rejection in liver xenotransplantation
Zhongqiang ZHANG, Shuozhou LIANG, Zhongzhou SI, Haizhi QI
2022, 38(10): 2210-2213. DOI: 10.3969/j.issn.1001-5256.2022.10.003
Abstract(712) HTML (478) PDF (1978KB)(102)
Abstract:
Liver transplantation is a curable therapy to save the life of patients with end-stage liver diseases of different causes. The serious shortage of liver donors led to the death of a large number of patients with end-stage liver disease. Genetic-engineered pigs used for xenotransplantation are one of...
The discussion on the Genetically Modified Pigs for the treatment of acute liver failure
Guoli Huai, Jiaxiang Du, Dengke Pan
2022, 38(10): 2214-2218. DOI: 10.3969/j.issn.1001-5256.2022.10.004
Abstract(605) HTML (107) PDF (1769KB)(95)
Abstract:
Liver transplants are in huge demand in China, but facing the problem of extreme shortage of donor organs. Xenogeneic (pig) liver transplantation may be a potential way to alleviate the shortage of donors. The liver is a detoxifying organ with synthetic functions, and when genetically modified pigs ...
Guideline
An excerpt from AASLD Practice Guidance on drug, herbal and dietary supplement-induced liver injury
Jing JING, Tingting HE, Zhaofang BAI, Jiabo WANG, Ruilin WANG, Xiaohe XIAO
2022, 38(10): 2219-2223. DOI: 10.3969/j.issn.1001-5256.2022.10.005
Abstract(839) HTML (252) PDF (2404KB)(230)
Abstract:
Original Article_Viral Hepatitis
Dynamic changes of serum hepatitis B virus DNA and HBsAg in patients with chronic hepatitis B treated with tenofovir disoproxil fumarate for 3 years
Rui LU, Shuangsuo DANG, Yixin LIU, Yikai WANG, Chenrui LIU, Yaping LI, Fengping WU, Mei LI
2022, 38(10): 2224-2229. DOI: 10.3969/j.issn.1001-5256.2022.10.006
Abstract(947) HTML (254) PDF (2009KB)(167)
Abstract:
Objective To assess the efficacy of tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) patients receiving antiviral therapy for three years. Methods A total of 157 CHB patients treated with TDF alone for ≥3 years from January 2015 to August 2020 in the Second Affiliated Hospital of Xi'...
Clinical characteristics and prognosis of patients with chronic hepatitis B combined with metabolic associated fatty liver disease
Weihong LIU, Hui LIU, Huiguo DING, Lei LI
2022, 38(10): 2230-2235. DOI: 10.3969/j.issn.1001-5256.2022.10.007
Abstract(694) HTML (384) PDF (2115KB)(165)
Abstract:
Objective To analyze the clinical characteristics and prognostic factors of chronic hepatitis B (CHB) patients complicated with metabolic associated fatty liver disease (MAFLD). Methods A total of 114 CHB patients and 101 CHB patients complicated with MAFLD who underwent liver biopsy between 2005 an...
Correlation analysis of hepatic fibrosis and renal injury in patients with chronic hepatitis B
Lu XIAO, Xuebing YAN, Yuanyuan FEI
2022, 38(10): 2236-2241. DOI: 10.3969/j.issn.1001-5256.2022.10.008
Abstract(556) HTML (135) PDF (2160KB)(82)
Abstract:
Objective To analyze the relationship between liver fibrosis and renal injury in patients with chronic hepatitis B (CHB). Methods We retrospectively analyzed the renal function of 798 CHB patients who were enrolled from May 2010 to October 2019. According to the quartile of fibrosis-4 (FIB-4) index,...
Value of aMAP score in prediction of hepatocellular carcinoma risk in outpatients with chronic hepatitis B virus infection
Limin WANG, Hongfei ZHANG, Yu GAN, Si XIE, Jingyue WANG, Yuan HUANG
2022, 38(10): 2242-2246. DOI: 10.3969/j.issn.1001-5256.2022.10.009
Abstract(696) HTML (471) PDF (1845KB)(64)
Abstract:
Objective To assess the aMAP risk in prediction of hepatocellular carcinoma (HCC) risk in outpatients with chronic hepatitis B virus (HBV) infection. Methods A total of 709 patients with chronic HBV infection were recruited for calculation of the aMAP scores and then stratified for HCC risk statisti...
Original Article_Fatty Liver Diseases
Correlation between cardiometabolic index and metabolic-associated fatty liver disease
Yunxia WU, Chengliang LI, Xiaolei LI, Zhaoxiao LUO, Tianshun REN
2022, 38(10): 2247-2251. DOI: 10.3969/j.issn.1001-5256.2022.10.010
Abstract(713) HTML (589) PDF (1815KB)(93)
Abstract:
Objective To analyze association of the cardiometabolic index (CMI) with risk of metabolism-associated fatty liver disease (MAFLD). Methods This study recruited 480 individuals from Inpatient Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical College from January 2018 to ...
Original Article_Liver Fibrosis and Liver Cirrhosis
Influencing factors for low-level viremia in patients with chronic hepatitis B or hepatitis B liver cirrhosis and its association with the progression of liver inflammation and liver fibrosis
Bibi XUAN, Yonghong XU, Zhongcai DU, Yu LIU, Yuling YANG, Cheng BIAN
2022, 38(10): 2252-2259. DOI: 10.3969/j.issn.1001-5256.2022.10.011
Abstract(624) HTML (216) PDF (1822KB)(102)
Abstract:
Objective To investigate the influencing factors for low-level viremia (LLV) in patients with chronic hepatitis B (CHB) or hepatitis B liver cirrhosis (LC) receiving antiviral therapy and the association of LLV with the progression of liver inflammation and liver fibrosis. Methods A total of 417 pat...
Association of JAK/STAT signaling pathway with portal vein thrombosis after splenectomy in cirrhotic patients with portal hypertension
Huan WANG, Xiaoxu SHEN, Liangqi CHEN, Tianlan GONG
2022, 38(10): 2260-2264. DOI: 10.3969/j.issn.1001-5256.2022.10.012
Abstract(429) HTML (100) PDF (1970KB)(30)
Abstract:
Objective To investigate the role of the Janus tyrosine kinase (JAK)- signal transducer and activators of transcription (STAT) signaling pathway in thrombosis formation after splenectomy in cirrhotic patients with portal hypertension. Methods A total of 198 liver cirrhosis patients with portal hyper...
Shugan Heluo Xingpi Decoction inhibits liver fibrosis through regulation of Wnt/β-Catenin signaling pathway
Kuisong WANG, Qiuju ZHANG, Shuyao WEI, Shipeng YIN, Jieyu LI, Shiyu CHEN, Jiaqi GUO, Kunpeng ZHAO
2022, 38(10): 2265-2272. DOI: 10.3969/j.issn.1001-5256.2022.10.013
Abstract(411) HTML (160) PDF (4203KB)(41)
Abstract:
Objective To investigate the therapeutic effect of Shugan Heluo Xingpi Decoction on CCl4-induced liver fibrosis in rats, and the underlying molecular mechanism. Methods Sixty male SPF Wistar rats were randomly assigned to six groups: blank control, model, positive control, high, medium or low dose g...
Role and mechanism of caffeic acid phenethyl ester in hepatic stellate cell
Ning YANG, Jiang DENG, Yikai WANG, Sha CHANG, Ning GAO, Wenjun WANG, Shuangsuo DANG, Juanjuan SHI
2022, 38(10): 2273-2278. DOI: 10.3969/j.issn.1001-5256.2022.10.014
Abstract(470) HTML (156) PDF (3612KB)(38)
Abstract:
Objective To assess the effect and underlying molecular events of caffeic acid phenethyl ester (CAPE) on rat hepatic stellate HSC-T6 cells. Methods HSC-T6 cells were grown and treated with different concentrations of CAPE (5, 10, or 15 μmol/L), transfected with or without LC3-GFP plasmid, and then t...
Effect of serum containing Huangqi decoction on the proliferation, migration, and tubulogenesis of rat liver sinusoidal endothelial cells induced by vascular endothelial growth factor and its mechanism of action
Haoyi WANG, Jingyin MAI, Jian PING, Yang CHENG
2022, 38(10): 2279-2285. DOI: 10.3969/j.issn.1001-5256.2022.10.015
Abstract(959) HTML (262) PDF (3258KB)(64)
Abstract:
Objective To investigate the effect of serum containing Huangqi decoction on the proliferation, migration, and tubulogenesis of rat liver sinusoidal endothelial cells (LSECs) induced by vascular endothelial growth factor (VEGF) and its mechanism of action based on the protein kinase B (AKT)/mammalia...
Original Article_Liver Neoplasms
Influence of the interval between transcatheter arterial embolization and radiofrequency ablation on the treatment outcome of small hepatocellular carcinoma
Yu SUN, Honghai ZHANG, Jiang LONG, Shoupeng SHENG, Jiasheng ZHENG, Yonghong ZHANG
2022, 38(10): 2286-2289. DOI: 10.3969/j.issn.1001-5256.2022.10.016
Abstract(471) HTML (112) PDF (1758KB)(38)
Abstract:
Objective To investigate the influence of the interval between transcatheter arterial embolization (TAE) and radiofrequency ablation on the treatment outcome of small hepatocellular carcinoma. Methods A total of 70 patients with hepatocellular carcinoma who received treatment in Beijing YouAn Hospit...
Risk factors of rebleeding after endoscopic treatment of patients with portal vein tumor thrombus and esophagogastric variceal bleeding
Xiuxia LIANG, Lingling HE, Junru YANG, Fuyang ZHANG, Jiali MA, Yuling ZHOU, Julong HU, Ping LI, Hongshan WEI
2022, 38(10): 2290-2295. DOI: 10.3969/j.issn.1001-5256.2022.10.017
Abstract(584) HTML (91) PDF (2924KB)(36)
Abstract:
Objective To analyze the rebleeding rate in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) after endoscopic treatment of esophagogastric variceal bleeding and then assessed the risk factors of the rebleeding in the patients. Methods This study retrospectively recruite...
Original Article_Other Liver Diseases
Clinical features of Polygonum multiflorum preparation-related liver injury with or without positive autoantibody
Jing CAI, Guiqin ZHOU, Yaxing LIU, Bin LI, Xiaojing WANG, Ying FENG, Xianbo WANG
2022, 38(10): 2296-2301. DOI: 10.3969/j.issn.1001-5256.2022.10.018
Abstract(557) HTML (151) PDF (1991KB)(53)
Abstract:
Objective To investigate the clinical features of patients with Polygonum multiflorum preparation-related liver injury with or without positive autoantibody based on propensity score matching, as well as the influence of positive autoantibody on the prognosis of such patients. Methods A total of 364...
Effect of glucocorticoid in the treatment of severe drug-induced liver injury
Wei YAN, Huifang HUANG
2022, 38(10): 2302-2307. DOI: 10.3969/j.issn.1001-5256.2022.10.019
Abstract(637) HTML (200) PDF (1781KB)(108)
Abstract:
Objective To investigate the therapeutic effect of glucocorticoid in patients with severe drug-induced liver injury (DILI). Methods A retrospective analysis was performed for the data of patients with severe DILI who were admitted to The First Hospital of Shanxi Medical University from January 2019 ...
Prognosis and adverse reactions of patients with acute-on-chronic liver failure receiving artificial liver support therapy stratified by international normalized ratio
Yuyu ZENG, Dakai GAN, Nengwen XIE, Jiao WAN, Molong XIONG
2022, 38(10): 2308-2312. DOI: 10.3969/j.issn.1001-5256.2022.10.020
Abstract(472) HTML (125) PDF (2000KB)(44)
Abstract:
Objective To investigate the prognosis and adverse reactions of patients with acute-on-chronic liver failure (ACLF) receiving artificial liver support therapy stratified by international normalized ratio (INR). Methods A total of 515 ACLF patients who received artificial liver support therapy in Dep...
Original Article_Pancreatic Diseases
Relationship between visceral fat related index and the severity of acute pancreatitis
Heming HUANG, Huiying YANG, Yingying QIN, Guodu TANG
2022, 38(10): 2313-2319. DOI: 10.3969/j.issn.1001-5256.2022.10.021
Abstract(560) HTML (222) PDF (2160KB)(66)
Abstract:
Objective To investigate the relationship between visceral fat related index and the severity of acute pancreatitis (AP). Methods A total of 308 patients hospitalized with AP at the First Affiliated Hospital of Guangxi Medical University from September 2014 to October 2021 were included. They were d...
Efficacy of magnetic resonance IDEAL-IQ technique in diagnosis of fat and iron deposition in acute pancreatitis
Huifang FAN, Qiang CHEN, Xiaojun YUAN, Lin LUO
2022, 38(10): 2320-2324. DOI: 10.3969/j.issn.1001-5256.2022.10.022
Abstract(713) HTML (343) PDF (2190KB)(53)
Abstract:
Objective To perform quantitative evaluation of fat and iron deposition in the pancreas of patients with acute pancreatitis (AP) based on the IDEAL-IQ quantitative parameters fat fraction (FF) and relaxation rate (R2*), and to investigate the efficacy of this technique in the diagnosis of AP. Method...
Establishment and application of a preoperative grading system for resectable pancreatic cancer
Chengfang WANG, Zhijiang WANG, Weilin WANG
2022, 38(10): 2325-2333. DOI: 10.3969/j.issn.1001-5256.2022.10.023
Abstract(387) HTML (308) PDF (2058KB)(50)
Abstract:
Objective To investigate the risk factors for early recurrence of resectable pancreatic cancer and the establishment and application of a grading system. Methods A retrospective case-control study was conducted among 303 patients with resectable pancreatic cancer who underwent radical resection in D...
Case Reports
Hepatitis C combined with diffuse large B-cell lymphoma: A case report
Zhixin TU, Jianjie HUANG, Yan WANG, Bo MA, Yujin HAN, Liang GUO, Xiaoyu WEN, Qinglong JIN
2022, 38(10): 2334-2336. DOI: 10.3969/j.issn.1001-5256.2022.10.024
Abstract(373) HTML (149) PDF (2373KB)(44)
Abstract:
Bacteremia in an elderly patient with cirrhotic after transjugular intrahepatic portosystemic shunt: A case report
Qin LIU, Xin YAO, Ying LI, Sheng HE, Shanhong TANG, Jianping QIN
2022, 38(10): 2337-2340. DOI: 10.3969/j.issn.1001-5256.2022.10.025
Abstract(621) HTML (138) PDF (2493KB)(50)
Abstract:
Hepatic veno-occlusive disease complicated with peripancreatic effusion misdiagnosed as acute pancreatitis: A case report
Jiaoshun CHEN, Haoxiang ZHANG, Tao YIN
2022, 38(10): 2341-2343. DOI: 10.3969/j.issn.1001-5256.2022.10.026
Abstract(477) HTML (147) PDF (2266KB)(41)
Abstract:
Treatment of unresectable periampullary carcinoma with irreversible electroporation: A case report
Caixia HU, Peng ZHAO, Bojun LIU, Jiasheng ZHENG, Yonghong ZHANG
2022, 38(10): 2344-2345. DOI: 10.3969/j.issn.1001-5256.2022.010.027
Abstract(547) HTML (264) PDF (1924KB)(41)
Abstract:
Reviews
Research advances in inflammatory markers in predicting the prognosis of patients with HBV-related acute-on-chronic liver failure
Tingting DENG, Li LI, Ying GUAN, Xueyan LUO, Kun QIN, Min LIU
2022, 38(10): 2346-2351. DOI: 10.3969/j.issn.1001-5256.2022.10.028
Abstract(614) HTML (142) PDF (1789KB)(78)
Abstract:
Acute-on-chronic liver failure (ACLF) is a clinical syndrome with short-term rapid deterioration, multiple organ failure, and high mortality and has become a research hotspot in the field of severe liver diseases. Early, accurate, and quick judgment of clinical prognosis and timely intervention of d...
Application of artificial intelligence and machine learning in non-alcoholic fatty liver research
Gong FENG, Xueying WANG, Shanshan LI, Na HE, Haoyun ZHENG, Man MI, Qinqin YAN
2022, 38(10): 2352-2356. DOI: 10.3969/j.issn.1001-5256.2022.10.029
Abstract(857) HTML (302) PDF (1869KB)(152)
Abstract:
Non-alcoholic fatty liver disease (NAFLD) incidence is rapidly increasing and become the most common chronic liver disease globally. NAFLD also possesses a risk of developing cardiovascular, kidney, and other diseases. To date, NAFLD still faces difficulties in early diagnosis and treatment options....
Association between the sirtuin family of deacetylases and nonalcoholic fatty liver disease
Yekai ZONG, Jiangkai LIU
2022, 38(10): 2357-2361. DOI: 10.3969/j.issn.1001-5256.2022.10.030
Abstract(524) HTML (162) PDF (1771KB)(52)
Abstract:
The sirtuin family of deacetylases widely exists in human cells and can regulate the post-translational chemical modification of various proteins by acting on mitochondria, endoplasmic reticulum and nucleus, thereby influencing the process of biological metabolism. The sirtuin family is also involve...
Role of bile acid metabolism in the pathogenesis of primary biliary cholangitis
Wanting JIA, Xiaoxiao LIU, Wenlin TAI
2022, 38(10): 2362-2367. DOI: 10.3969/j.issn.1001-5256.2022.10.031
Abstract(751) HTML (168) PDF (1789KB)(97)
Abstract:
Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by a high incidence rate in middle-aged and elderly women, lymphocyte infiltration in small bile ducts, and cholestasis. Main clinical manifestations include fatigue and pruritus caused by cholestasis. Ursodeox...
Role of inflammation in hepatic fibrosis
Ting LI, Huabao LIU, Wenyan HU, Chunyan RAO
2022, 38(10): 2368-2372. DOI: 10.3969/j.issn.1001-5256.2022.10.032
Abstract(1321) HTML (247) PDF (1986KB)(299)
Abstract:
Inflammation caused by chronic liver is primarily responsible for the occurrence and pathological progression of liver fibrosis. In the process of liver fibrosis, a large number of activated inflammatory signals promote the transformation of hepatic stellate cells (HSC) into myofibroblasts (MF), whi...
Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis
Shiheng LIU, Suxian ZHAO, Yuguo ZHANG
2022, 38(10): 2373-2377. DOI: 10.3969/j.issn.1001-5256.2022.10.033
Abstract(741) HTML (202) PDF (1774KB)(86)
Abstract:
Liver fibrosis occurs due to damages caused by liver diseases of various etiologies and activation of hepatic stellate cells, leading to the repairing and damaging cycle by secreting a large amount of extracellular matrix and formation of fibrosis tissues in the liver. Early reversal of this process...
Research advances in porto-sinusoidal vascular disease
Liang LIU, Jiangkai LIU, Tiantian LIU, Jianwen ZHANG, Yaru ZHANG, Bingqian LI
2022, 38(10): 2378-2382. DOI: 10.3969/j.issn.1001-5256.2022.10.034
Abstract(993) HTML (1023) PDF (1768KB)(156)
Abstract:
The term porto-sinusoidal vascular disease (PSVD) was proposed in 2017 to replace "idiopathic non-cirrhotic portal hypertension", so as to describe typical histological changes involving the portal vein or the hepatic sinus in the absence of liver cirrhosis. According to the definition of PSVD, pati...
Role of bile acids in cirrhosis-related cardiomyopathy
Shiyang LIANG, Qiang LIN, Junliang SONG, Jingjie WANG
2022, 38(10): 2383-2386. DOI: 10.3969/j.issn.1001-5256.2022.10.035
Abstract(623) HTML (244) PDF (1756KB)(71)
Abstract:
Liver cirrhosis-related cardiomyopathy (CCM) is a common and easily overlooked complication associated with liver cirrhosis. Because of the high incidence and impact on success of the liver transplantation and the transcarotid intrahepatic portosystemic shunt surgery, it has attracted the attention ...
Application of chimeric antigen receptor T-cell immunotherapy in primary liver cancer
Kangwei LI, Ding WEI, Ruohan ZHANG, Xiao LI, Kaishan TAO
2022, 38(10): 2387-2390. DOI: 10.3969/j.issn.1001-5256.2022.10.036
Abstract(609) HTML (131) PDF (1761KB)(60)
Abstract:
Primary liver cancer has the features of high malignancy, rapid progression, frequent recurrence/metastasis, and high mortality, and therefore, most patients have developed intrahepatic or extrahepatic metastasis when attending the hospital and thus lost the opportunity for surgical treatment. Chime...
Recent advancement in research on intrahepatic cholangiocarcinoma: Risk factors and pathogenesis
Yu LIANG, Yuanhong ZHAO, Zheng LI
2022, 38(10): 2391-2395. DOI: 10.3969/j.issn.1001-5256.2022.10.037
Abstract(1233) HTML (225) PDF (2345KB)(94)
Abstract:
Intrahepatic cholangiocarcinoma (ICC) accounts for the second highest hepatobiliary malignancy after hepatocellular carcinoma. ICC has a complex etiology and is a high invasive disease with a poor prognosis. To date, surgical resection is still the best treatment to cure early staged ICCs clinically...
Anticoagulants for artificial liver support therapy: Application advances and selection strategies
Yuanji MA, Lingyao DU, Lang BAI, Hong TANG
2022, 38(10): 2396-2401. DOI: 10.3969/j.issn.1001-5256.2022.10.038
Abstract(1655) HTML (409) PDF (2107KB)(172)
Abstract:
Coagulation disorder is one of the characteristics of liver failure, leading to an unstable and vulnerable "rebalance" state of coagulation function, which may be easily broken by internal or external factors. Anticoagulants are often required during artificial liver support therapy for patients wit...
Role of oxidative stress in acute liver injury
Yue LIAO, Yihuai HE, Yawen LUO
2022, 38(10): 2402-2407. DOI: 10.3969/j.issn.1001-5256.2022.10.039
Abstract(1696) HTML (1321) PDF (2490KB)(230)
Abstract:
Acute liver injury (ALI) is often caused by virus infection, alcohol, drugs, toxin, and metabolic disorder, and oxidative stress is a common pathophysiological mechanism in the development and progression of ALI and other liver diseases. Hepatocyte function is impaired after ALI, which further cause...
Vasoactive substance resistance mechanisms in diagnosis and treatment of end-stage liver diseases: Disputes and counter-measurement
Jianjun LIU, Wenkai ZHENG, Jianghong WANG, Yanjun REN, Yan LIU, Lizhen ZHAO
2022, 38(10): 2408-2411. DOI: 10.3969/j.issn.1001-5256.2022.10.040
Abstract(533) HTML (107) PDF (1753KB)(36)
Abstract:
The vasoactive substance resistance (VSR) in the end-stage liver disease (ESLD) refers as the reduction of patients' responsiveness to endogenous and exogenous vasoactive substances, cardiac and vascular excitability, peripheral circulatory dysfunction, but induction of related adverse events. VSR i...
Application and progress of the contrast-enhanced ultrasound liver imaging reporting and data system (CEUS LI-RADS) in "M" lesions
Xingni WU, Shaoshan TANG, Xiang LI, Zinan LI
2022, 38(10): 2412-2415. DOI: 10.3969/j.issn.1001-5256.2022.10.041
Abstract(816) HTML (141) PDF (1762KB)(39)
Abstract:
Clinically, there are still substantial differences between hepatocellular carcinoma (HCC) and non-HCC liver malignancies in terms of risk factors, pathogenesis, biological behaviors, treatment selections, prognosis, and prevention measurement. The liver imaging reporting and data system (LI-RADS) M...
Ischemic hepatitis: A severe liver disease that cannot be neglected
Kai ZHU, Hongmei XU
2022, 38(10): 2416-2421. DOI: 10.3969/j.issn.1001-5256.2022.010.042
Abstract(1381) HTML (123) PDF (1782KB)(106)
Abstract:
Ischemic hepatitis is increasingly common in the intensive care unit and often has a poor prognosis. Due to the complex pathogenesis of ischemic hepatitis and a lack of specific clinical manifestations, auxiliary examination methods are limited and there are still no unified diagnostic criteria and ...
The progression of biliary hyperkinesia research
Wenping LIANG, Dankun LUO, Bo LIU, Dongbo XUE, Biao MA
2022, 38(10): 2422-2427. DOI: 10.3969/j.issn.1001-5256.2022.10.043
Abstract(781) HTML (266) PDF (2443KB)(68)
Abstract:
In recent years, the incidence of digestive disorders has risen steadily. Among which, biliary dyskinesia, particularly biliary hyperkinesia, has become a growing concern. The basic concept, epidemiology, pathogenesis, pathology, clinical and imaging manifestations, diagnosis, and treatment of bilia...
Advances in tumor microenvironment and immunotherapy of Cholangiocarcinoma
Shun CHEN, Jun WANG
2022, 38(10): 2428-2432. DOI: 10.3969/j.issn.1001-5256.2022.10.044
Abstract(734) HTML (475) PDF (1923KB)(70)
Abstract:
The tumor microenvironment plays an important role in the proliferation, invasion and metastasis of cholangiocarcinoma cells. Complicated functional axis determines cholangiocarcinoma heterogeneity and its malignant potential. Targeting some factors in the tumor microenvironment might help reshape i...
Introduction of High-quality Articles in Foreign Journals
Hepatology｜Declining disease burden of HCC in the United States, 1992-2017: A population-based analysis
2022, 38(10): 2259-2259. DOI: 10.3969/j.issn.1001-5256.2022.10.gwjpwzjj1
Abstract(269) HTML (87) PDF (807KB)(46)
Abstract:
Hepatology｜Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: A randomized controlled trial
2022, 38(10): 2285-2285. DOI: 10.3969/j.issn.1001-5256.2022.10.gwjpwzjj2
Abstract(313) HTML (140) PDF (972KB)(59)
Abstract:
Journal of Clinical Oncology｜Neoadjuvant chemoradiotherapy versus upfront surgery for resectable and borderline resectable pancreatic cancer: long-term results of the Dutch randomized PREOPANC trial
2022, 38(10): 2312-2312. DOI: 10.3969/j.issn.1001-5256.2022.10.gwjpwzjj3
Abstract(276) HTML (258) PDF (819KB)(65)
Abstract:
Thanks
Current reviewers
2022, 38(10): 2223-2223. DOI: 10.3969/j.issn.1001-5256.2022.10.zhixie1
Abstract(409) HTML (108) PDF (1247KB)(40)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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