Liver xenotransplantation techniques: Characteristics and difficulties

Xiao LI; Kaishan TAO

doi:10.3969/j.issn.1001-5256.2022.10.002

Volume 38 Issue 10

Oct. 2022

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Liver xenotransplantation techniques: Characteristics and difficulties

DOI: 10.3969/j.issn.1001-5256.2022.10.002

Xiao LI,
Kaishan TAO^{,
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Department of Hepato-Biliary Surgery and Army Institute of Organ Transplantation, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, China

Research funding:

National Natural Science Foundation of China (82070681);

National Natural Science Foundation of China (82170667);

National Natural Science Foundation of China (82070671);

National Natural Science Foundation of China (81970566);

Shaanxi Natural Science Basic Research Project (2022JM-537);

Xijing Hospital Discipline Assistance Program Supporting Project (XJZT21CM14);

Medical Research Project (AKJ19J001);

Medical Research Project (18CXZ014)

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Corresponding author: TAO Kaishan, taokaishan0686@163.com(ORCID: 0000-0002-8573-0445)
Received Date: 2022-08-01
Accepted Date: 2022-08-31
Published Date: 2022-10-20

Abstract

Abstract

The rapid development of gene editing technology showed usefulness of pig xenotransplantation as a donor in clinical application. Clinical trials of non-human primates using pig heart and kidney were able to survive them for a long period of time, while the longest survival of xenograft liver transplantation was nearly 1 month, which could meet the conditions for entering clinical trials for human patients. However, compared with heart and kidney transplantation, only a few units in the world can carry out xenograft liver transplantation due to the high technical difficulty and difficult perioperative management. This review summarized the advancement and progress in the field and discussed the technical characteristics and difficulties, so as to provide experience and reference for the future development of clinical trials, i.e., comparison of pig and liver anatomy, animal models of xenograft liver transplantation, and characteristics and difficulties in liver xenotransplantation technique.
- Liver Transplantation,
- Transplantation, Heterologous,
- Surgical Procedures, Operative

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References(23)

References

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Liver xenotransplantation techniques: Characteristics and difficulties

DOI: 10.3969/j.issn.1001-5256.2022.10.002

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Liver xenotransplantation techniques: Characteristics and difficulties

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