Risk factors of rebleeding after endoscopic treatment of patients with portal vein tumor thrombus and esophagogastric variceal bleeding

Xiuxia LIANG; Lingling HE; Junru YANG; Fuyang ZHANG; Jiali MA; Yuling ZHOU; Julong HU; Ping LI; Hongshan WEI

doi:10.3969/j.issn.1001-5256.2022.10.017

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2290-2295

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Risk factors of rebleeding after endoscopic treatment of patients with portal vein tumor thrombus and esophagogastric variceal bleeding

DOI: 10.3969/j.issn.1001-5256.2022.10.017

Department of Gastroenterology, Beijing Ditan Hospital, The Capital Medical University, Beijing 100015, China

Research funding:

National Natural Science Foundation of China (82170541);

Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals (XXZ0404);

Natural Science Foundation of Capital Medical University (PYZ20031)

More Information

Corresponding author: WEI Hongshan, drwei@ccmu.edu.cn(ORCID: 0000-0001-8893-653X)
Received Date: 2022-03-09
Accepted Date: 2022-06-06
Published Date: 2022-10-20

Abstract

Abstract

Objective To analyze the rebleeding rate in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) after endoscopic treatment of esophagogastric variceal bleeding and then assessed the risk factors of the rebleeding in the patients. Methods This study retrospectively recruited 169 hepatitis B-associated HCC patients complicated with PVTT and esophagogastric variceal bleeding treated by endoscopy in Department of Gastroenterology, Beijing Ditan Hospital from September 2008 to December 2016. Among them, 47 patients had PVTT Ⅱ, 67 patients had PVTT Ⅲ, and 55 patients had PVTT Ⅳ. Their clinicopathological and follow-up data were retrieved from the medical records and statistically analyzed. Continuous data were compared among groups using ANOVA or Kruskal-Wallis H test. Categorial data were compared among groups using Chi-square test or corrected Fisher test. The Kaplan-Meier curves and Log-rank test were performed to analyze the rebleeding rate and cumulative survival rates after treatment. The univariate multivariate Cox regression analyses were used to identify the risk factors affecting the rebleeding of patients. Results Compared with PVTT Ⅱ and Ⅲ, PVTT Ⅳ patients had a higher serum level of the direct bilirubin (Z=6.153, P=0.046). The endoscopy treatment successfully blocked esophagogastric variceal bleeding in all patients. There was no significant difference in the rebleeding rates within six months and a year after the treatment (all P > 0.05). It was also no statistically significant difference in cumulative survival rates in six months and l-, 2-, and 3-year after the treatment in PVTT Ⅱ, Ⅲ, and Ⅳ patients (all P > 0.05). Cox multivariate regression analysis showed that hepatic encephalopathy (HR=3.643, 95%CI: 2.099-6.325, P < 0.001), γ-glutamyltransferase (HR=1.002, 95%CI: 1.000-1.005, P=0.029), AFP (HR=1.000, 95%CI: 1.000-1.000, P=0.002) and numbers of tumor lesions (HR=1.647, 95%CI: 1.011-2.684, P=0.045) were all independent risk factors for 1-year rebleeding in these PVTT patients with esophagogastric variceal bleeding after endoscopic treatment. Conclusion Endoscopic hemostasis is a feasible treatment option for HCC patients with PVTT and esophagogastric variceal bleeding. However, there was no significant difference in the rebleeding and cumulative survival rates in these patients. Furthermore, hepatic encephalopathy, γ-glutamyltransferase, AFP and numbers of tumor lesions were all independent risk factors for 1-year rebleeding in these patients.
- Carcinoma, Hepatocellular,
- Portal Vein,
- Esophageal and Gastric Varices,
- Endoscopes,
- Therapeutics,
- Hemorrhage

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References(21)

References

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Risk factors of rebleeding after endoscopic treatment of patients with portal vein tumor thrombus and esophagogastric variceal bleeding

DOI: 10.3969/j.issn.1001-5256.2022.10.017