Recent advancement in research on intrahepatic cholangiocarcinoma: Risk factors and pathogenesis

Yu LIANG; Yuanhong ZHAO; Zheng LI

doi:10.3969/j.issn.1001-5256.2022.10.037

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2391-2395

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Recent advancement in research on intrahepatic cholangiocarcinoma: Risk factors and pathogenesis

DOI: 10.3969/j.issn.1001-5256.2022.10.037

Yu LIANG¹,
Yuanhong ZHAO¹,
Zheng LI^{2
,
,
,}

1.
Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
2.
Department of Pharmaceutical Preparations, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China

Research funding:

Project of Clinical Research Association of Chinese Medicine Higher Education Society (2019ZYGJ006);

Tianjin Municipal Science and Technology Commission Special Scientific and Technology Project for Chronic Disease Prevention and Control (17ZXMFSY00190)

More Information

Corresponding author: LI Zheng, lizheng9899@163.com(ORCID: 0000-0003-3737-1131)
Received Date: 2022-03-13
Accepted Date: 2022-04-14
Published Date: 2022-10-20

Abstract

Abstract

Intrahepatic cholangiocarcinoma (ICC) accounts for the second highest hepatobiliary malignancy after hepatocellular carcinoma. ICC has a complex etiology and is a high invasive disease with a poor prognosis. To date, surgical resection is still the best treatment to cure early staged ICCs clinically; however, due to ICC diagnosis at the advanced stages of disease and tumor with high degree of malignancy, most patients miss the optimal time for surgery. Thus, it is crucial to detect and intervene ICC at the earliest stage of disease clinically. The ICC risk factors may include primary sclerosing cholangitis, viral hepatitis, and intrahepatic cholangiolithiasis. The rapid development of molecular biology and genetics provides a better methodology in in-depth study of ICC pathogenesis. This review summarized and discussed the most recent advancement in identification of the ICC risk factors and molecular mechanisms of ICC pathogenesis, which may provide valuable and insightful information for ICC early detection and potential treatment strategy.
- Bile Duct Neoplasms,
- Risk Factors,
- Pathologic Processes

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References(43)

References

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Recent advancement in research on intrahepatic cholangiocarcinoma: Risk factors and pathogenesis

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Recent advancement in research on intrahepatic cholangiocarcinoma: Risk factors and pathogenesis

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