Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis

Yuhao YAO; Jiaxin ZHANG; Xiao XIA; Shun ZHU; Xiaoke LI; Yong'an YE

doi:10.3969/j.issn.1001-5256.2022.11.013

Volume 38 Issue 11

Nov. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(11): 2505-2509

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Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2022.11.013

Yuhao YAO^{1, 2},
Jiaxin ZHANG^{2, 3},
Xiao XIA⁴,
Shun ZHU²,
Xiaoke LI^{2, 3
,
,
,},
Yong'an YE^{2, 3
,
,
,}

1.
First School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2.
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3.
Liver Diseases Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100700, China
4.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Research funding:

National Natural Science Foundation of China (82174341);

National Administration of Traditional Chinese Medicine Research Fund (JDZX2015300);

Beijing University of Traditional Chinese Medicine Start-up Fund (2022-JYB-XJSJJ-050)

More Information

Corresponding author: LI Xiaoke, lixiaoke@vip.163.com(ORCID: 0000-0002-1775-3063); YE Yong'an, yeyongan@vip.163.com(ORCID: 0000-0001-9765-4665)
Received Date: 2022-04-06
Accepted Date: 2022-05-10
Published Date: 2022-11-20

Abstract

Abstract

Objective To review and analyze the effect of probiotics in preventing the overt hepatic encephalopathy (OHE) in patients with minimal hepatic encephalopathy (MHE). Methods Studies about this subject were searched in PubMed, Web of Science, Cochrane Library, Chinese journal full-text database (CNKI), WanFang data knowledge service platform (WanFang Data) from their establishment to November 2021. Meta-analysis was performed using RevMan 5.4. Description analysis was used for data that could not be pooled. The relative risk (RR) and 95% confidence interval (CI) were used to present pooled data. Results Six RCT studies with a total of 404 patients were included in this meta-analysis. The results showed probiotics users had a significant reduction of the OHE incidence, as compared with the controls (RR=0.46, 95%CI: 0.26 - 0.81; P=0.007), but an increase in the reversal MHE rate (RR=4.94, 95%CI: 2.82-8.66; P < 0.000 01). Conclusion This finding demonstrated that probiotics were able to effectively reduce the OHE incidence and improve the reversal MHE rate in the patients with MHE. This study could provide novel evidence for probiotics treatment of MHE.
- Hepatic Encephalopathy,
- Probiotics,
- Meta-Analysis

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Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis

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Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis

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