2022 No. 11

2022 No.11

Theme Issue: Early Diagnosis and Treatment Strategy for Chronic Hepatitis B Special Populations

Executive Chief Editor: DOU Xiaoguang

Shengjing Hospital, China Medical University

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Editorial

Focus on the special population with hepatitis B virus infection: Early diagnosis, early treatment, and early benefits

Yanwei LI, Xiaoguang DOU

2022, 38(11): 2441-2443. DOI: 10.3969/j.issn.1001-5256.2022.11.001

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Hepatitis B virus (HBV) infection is a major public health problem worldwide. With the extensive prophylactic vaccination with hepatitis B vaccine for neonates and an increasing number of patients receiving antiviral treatment, remarkable achievements have been made in HBV infection among Chinese ch...

Discussions by Experts

Anti-HBV therapy timing and drug selection in various populations

Yeqiong ZHANG, Qiumin LUO, Lu WANG, Liang PENG, Zhiliang GAO

2022, 38(11): 2444-2447. DOI: 10.3969/j.issn.1001-5256.2022.11.002

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Hepatitis B virus (HBV) infection is still a serious disease threatening human health. Anti-HBV treatment is an extremely important means to reduce the threat of hepatitis B. In recent years, there has been no consensus on the timing and drug selection of anti-HBV therapy. The timing and drug select...

Antiviral therapy for pregnant women and children with chronic HBV infection

Aoxue CUI, Xiaoguang DOU, Yang DING

2022, 38(11): 2448-2451. DOI: 10.3969/j.issn.1001-5256.2022.11.003

Abstract(743)

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The most important measure for preventing mother-to-child transmission of HBV and reducing chronic HBV infection in children is enhancing the standardized management of chronic HBV infection in pregnant women and their infants. Pregnant women and children are special populations, and antiviral thera...

Selection of antiviral drugs for patients with hepatitis B virus-associated hepatocellular carcinoma

Mingyang FENG, Hui WANG

2022, 38(11): 2452-2456. DOI: 10.3969/j.issn.1001-5256.2022.11.004

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Hepatitis B virus (HBV) infection is a key risk factor for the development and progression of hepatocellular carcinoma (HCC) and it promotes the progression of HCC by inducing liver fibrosis, genetic and epigenetic alterations, and the expression of active virally encoded proteins. Many studies have...

Efficiency and safety of immune checkpoint inhibitors in cancer patients with chronic liver disease: A systematic review

Dan LIU, Tiantian YAO, Yuhan ZHANG, Guiqiang WANG, Yan WANG

2022, 38(11): 2457-2461. DOI: 10.3969/j.issn.1001-5256.2022.11.005

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Immune checkpoint inhibitors (ICIs) have recently been approved for the treatment of cancer, and the number of cancer patients with chronic liver disease (CLD) receiving ICIs is growing rapidly. However, whether CLD affects the efficiency and safety of ICIs is becoming a research focus. This review ...

Original Articles_Viral Hepatitis

Evaluation of quality of life instruments for chronic diseases-chronic hepatitis(V2.0)based on classical test theory and item response theory

Ye LIU, Jie LU, Dingchun LI, Wu LI, Yihui CHEN

2022, 38(11): 2470-2477. DOI: 10.3969/j.issn.1001-5256.2022.11.007

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Objective Each item of the Chronic Hepatitis Quality of Life Scale (V2.0) was thoroughly analyzed and evaluated according to classical test theory (CTT) and item response theory (IRT). Methods The QLICD-CH (V2.0) scale was used to assess the life quality of 226 patients with chronic hepatitis who we...

Value of age and D-dimer combined with Model for End-Stage Liver Disease in predicting the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure

Shaoyu DONG, Changyu SUN, Fangfang QIAO, Xiao LIU, Jianying ZHANG

2022, 38(11): 2478-2482. DOI: 10.3969/j.issn.1001-5256.2022.11.008

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Objective To investigate the value of age and D-dimer (D-D) combined with Model for End-Stage Liver Disease (MELD) score in predicting the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Methods A total of 111 patients with HBV-ACLF who were hospitaliz...

Original Articles_Autoimmune Liver Disease

Expression of autophagy marker in peripheral blood T and B lymphocytes of patients with autoimmune hepatitis and its clinical significance

Huili WU, Hongbo SHI, Yanmin LIU, Yan YAN, Lingling WANG, Mei DING, Zhenglai MA, Hui LIU, Zhongping DUAN

2022, 38(11): 2483-2487. DOI: 10.3969/j.issn.1001-5256.2022.11.009

Abstract(766)

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Objective To investigate the expression of autophagy marker in peripheral blood T and B lymphocytes of patients with autoimmune hepatitis (AIH) and its clinical significance. Methods Peripheral blood samples were collected from 62 AIH patients who were treated in Beijing YouAn Hospital affiliated to...

Original Articles_Liver Fibrosis and Liver Cirrhosis

Value of liver stiffness measured by acoustic radiation force impulse in diagnosis of cirrhotic portal hypertension

Xixuan WANG, Liangzi DING, Yang CHENG, Hao HAN, Jian YANG, Jiangqiang XIAO, Yi WANG, Ming ZHANG, Feng ZHANG, Yuzheng ZHUGE

2022, 38(11): 2488-2492. DOI: 10.3969/j.issn.1001-5256.2022.11.010

Abstract(506)

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Objective To investigate the accuracy of liver stiffness (LS) as a noninvasive index in predicting hepatic venous pressure gradient (HVPG) in patients with decompensated liver cirrhosis and the value of LS in the diagnosis of decompensated liver cirrhosis. Methods A retrospective analysis was perfor...

Developing the prediction model of esophagogastric variceal rebleeding in patients with liver cirrhosis based on artificial neural network

Qun ZHANG, ke SHI, Xianbo WANG

2022, 38(11): 2493-2498. DOI: 10.3969/j.issn.1001-5256.2022.11.011

Abstract(697)

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Objective To develop an artificial neural network model to predict the risk of rebleeding within one year in cirrhotic patients with esophagogastric variceal bleeding. Methods We retrospectively collected 441 cirrhotic patients with esophagogastric variceal bleeding hospitalized at Beijing Ditan Hos...

Establishment of a model for predicting the efficacy of third-generation cephalosporin in treatment of community-acquired spontaneous bacterial peritonitis

Longchuan ZHU, Wei WU, Bo ZOU, Dakai GAN, Xue LIN, Wei ZHOU, Molong XIONG

2022, 38(11): 2499-2504. DOI: 10.3969/j.issn.1001-5256.2022.11.012

Abstract(418)

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Objective To investigate the factors for predicting the efficacy of third-generation cephalosporin (3^rd GC) in the treatment of community-acquired spontaneous bacterial peritonitis (CASBP), and to establish and validate an efficacy predictive model for 3^rd GC in the treatment of CASBP. Methods A ret...

Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis

Yuhao YAO, Jiaxin ZHANG, Xiao XIA, Shun ZHU, Xiaoke LI, Yong'an YE

2022, 38(11): 2505-2509. DOI: 10.3969/j.issn.1001-5256.2022.11.013

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Objective To review and analyze the effect of probiotics in preventing the overt hepatic encephalopathy (OHE) in patients with minimal hepatic encephalopathy (MHE). Methods Studies about this subject were searched in PubMed, Web of Science, Cochrane Library, Chinese journal full-text database (CNKI)...

Original Articles_Liver Neoplasms

Short-term mortality and death causes after TACE in patients with primary liver cancer

Zhao LIU, Zhi LI, Kailun YANG, Siyin LI, Xiaoli ZHU, Caifang NI

2022, 38(11): 2510-2513. DOI: 10.3969/j.issn.1001-5256.2022.11.014

Abstract(868)

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Objective To investigate the short-term mortality of transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer, and explore the possible causes of death and countermeasures. Methods All patients who underwent TACE at the Department of Interventional Radiology, First Affil...

Prognostic value of KRAS mutations in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization

Xuchu LIU, Shiyun QIN, Lijun CHEN, Juan CHEN, Xiaoguang YOU

2022, 38(11): 2514-2519. DOI: 10.3969/j.issn.1001-5256.2022.11.015

Abstract(675)

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Objective To assess the prognostic value of KRAS mutation in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization (TACE). Methods Ninety-seven patients with advanced primary liver cancer who received TACE treatment in The Third People's hospital from Apri...

Construction and validation of a nomogram model for microvascular invasion in hepatocellular carcinoma based on the characteristics on contrast-enhanced ultrasound Liver Imaging Reporting and Data System

Jing XI, Meiqin GU, Zuowei BAO

2022, 38(11): 2520-2525. DOI: 10.3969/j.issn.1001-5256.2022.11.016

Abstract(496)

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Objective To construct and validate a nomogram model for predicting microvascular invasion (MVI) based on the characteristics on contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) in patients with hepatocellular carcinoma (HCC). Methods A total of 262 patients with...

Original Articles_Other Liver Diseases

Clinical efficacy of low-dose plasma exchange combined with double plasma molecular absorption system/hemoperfusion in treatment of acute-on-chronic liver failure

Jie LU, Dingchun LI, Ye LIU, Linna YUAN, Zhiwen DUAN, Wu LI

2022, 38(11): 2526-2531. DOI: 10.3969/j.issn.1001-5256.2022.11.017

Abstract(553)

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Objective To investigate the clinical efficacy of low-dose plasma exchange (PE) combined with artificial liver in the treatment of acute-on-chronic liver failure (ACLF) and its effect on mortality rate after stratification. Methods A total of 272 ACLF patients who were admitted to Department of Infe...

Risk factors for acute variceal bleeding in acute-on-chronic liver failure and its influence on prognosis

Wanshu LIU, Lijun SHEN, Qinghui ZHAI, Shaojie XIN, Shaoli YOU

2022, 38(11): 2532-2536. DOI: 10.3969/j.issn.1001-5256.2022.11.018

Abstract(586)

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Objective To investigate the risk factors for acute variceal bleeding (AVB) in acute-on-chronic liver failure (ACLF) and its influence on prognosis. Methods A total of 1409 ACLF patients who were admitted to The Fifth Medical Center of Chinese PLA General Hospital from 2009 to 2015 were followed up ...

Original Articles_Biliary Diseases

Application value of indocyanine green fluorescence imaging in laparoscopic cholecystectomy of difficult gallbladder

Qizhu FENG, Siyu WANG, Chao ZHANG

2022, 38(11): 2537-2541. DOI: 10.3969/j.issn.1001-5256.2022.11.019

Abstract(837)

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Objective To investigate the clinical utility of indocyanine green (ICG) fluorescence imaging in difficult laparoscopic cholecystectomy (LC). Methods The clinical data of LC patients from October 2021 to December 2021 in the First Affiliated Hospital of Anhui Medical University were retrospectively ...

Application and clinical evaluation of ultrasound-guided biliary drainage tube replacement technology

Anhong ZHANG, Ruixin ZHANG, jie MA, Bo QIU, Xin YI, Zhihua LU, Lijie ZHENG, Hanguang DONG, Tian HAN, Li ZHANG, Yuanhui JIANG, Jun XU

2022, 38(11): 2542-2545. DOI: 10.3969/j.issn.1001-5256.2022.11.020

Abstract(809)

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Objective To summarize the preliminary application results of ultrasound-guided biliary drainage tube replacement, present the corresponding technical points, and discuss the operation strategy and clinical application value. Methods The clinical data of 60 patients who underwent ultrasound-guided b...

Effect of trimetazidine on a rat model of bile duct ischemia-reperfusion injury and its mechanism

Jinrui ZHANG, Hao WU, Yi BAI, Yamin ZHANG

2022, 38(11): 2546-2550. DOI: 10.3969/j.issn.1001-5256.2022.11.021

Abstract(575)

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Objective To investigate the effect of trimetazidine on ischemic bile duct injury in rats and related mechanism. Methods A total of 40 male Sprague-Dawley rats were randomly divided into sham-operation group (Sham group with 10 rats), bile duct ischemia-reperfusion injury group (BIRI group with 10 r...

Original Articles_Pancreatic Diseases

Value of different scoring systems in predicting the severity and prognosis of hyperlipidemic acute pancreatitis

Qiu JIN, Jing YANG, Honglin MA, Pingju LI, Shaoshan HU, Qingqing LIU

2022, 38(11): 2551-2557. DOI: 10.3969/j.issn.1001-5256.2022.11.022

Abstract(536)

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Objective To investigate the best scoring systems for predicting the severity and prognosis of hyperlipidemic acute pancreatitis (HLAP) by comparing APACHEII, BISAP, MCTSI, MEWS, POP, SPS, and PANC3 scores. Methods A retrospective analysis was performed for the data of 123 patients with HLAP who wer...

Selection of treatment regimens for pancreatic duct stones: A comparative analysis

Jinbin DONG, Weibing FANG, Yihai SHI

2022, 38(11): 2558-2564. DOI: 10.3969/j.issn.1001-5256.2022.11.023

Abstract(494)

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Objective To investigate the clinical efficacy of endoscopic retrograde cholangiopancreatography (ERCP), laparoscopy, and laparotomy in the treatment of pancreatic duct stones (PDS) by collecting related clinical data, to summarize the experience in selecting treatment regimens for PDS, and to furth...

Case Reports

A diagnosis of atypical autoimmune hepatitis: A case report

Mengting ZHOU, Hongmei HAN

2022, 38(11): 2565-2567. DOI: 10.3969/j.issn.1001-5256.2022.11.024

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A case of type 3 progressive familial intrahepatic cholestasis

Tianying ZHANG, Chao ZHOU, Weihui LIU, Zhenmao LI, Liangping LI, Lei LEI

2022, 38(11): 2568-2570. DOI: 10.3969/j.issn.1001-5256.2022.11.025

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Hereditary hemochromatosis with multiple organ damage caused by HJV gene mutation in adults: A case report

Shuduo WU, Yibo ZHAN, Xinhua LI, Changlei XU, Minling CAO, Xiaoling CHI

2022, 38(11): 2571-2574. DOI: 10.3969/j.issn.1001-5256.2022.11.026

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A case of idiopathic hypereosinophilic syndrome presenting with progressive multiple vascular lesions

Qingfang XIONG, Hao REN, Hui ZHOU, Xiaoning FENG, Duxian LIU, Yandan ZHONG, Yongfeng YANG

2022, 38(11): 2575-2577. DOI: 10.3969/j.issn.1001-5256.2022.11.027

Abstract(409)

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Chronic pancreatitis caused by incomplete pancreas division: A case report

Meili DONG, Ruihua ZHANG, Tengfei LI, Yang WANG, Xiaoyu WEN

2022, 38(11): 2578-2580. DOI: 10.3969/j.issn.1001-5256.2022.11.028

Abstract(497)

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Reviews

Influencing factors for HBeAg seroconversion in patients with chronic hepatitis B

Ziyang GU, Anhui WANG, Wenchang HE, Jiayu LI, Changxing HUANG

2022, 38(11): 2581-2585. DOI: 10.3969/j.issn.1001-5256.2022.11.029

Abstract(1441)

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HBeAg seroconversion refers to the disappearance of HBeAg and the appearance of anti-HBe in chronic hepatitis B (CHB) patients with positive HBeAg in the past. HBeAg seroconversion marks the reductions in viral replication, immune tolerance, and liver inflammation and is an important monitoring indi...

Research advances in the relationship between nonalcoholic fatty liver disease and chronic kidney disease

Mengru YANG, Rui HAN

2022, 38(11): 2586-2591. DOI: 10.3969/j.issn.1001-5256.2022.11.030

Abstract(739)

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More and more studies have shown that nonalcoholic fatty liver disease (NAFLD) is closely associated with chronic kidney disease (CKD). Although the causal relationship has not been clarified, the mechanisms, such as metabolic disorders, diet-intestinal microbiota axis disorders, oxidative stress, p...

Risk factors for cognitive impairment associated with nonalcoholic fatty liver disease

Cheng ZHOU, Ran JIA, Jingjing WEI, Chenlu ZHAO, Dongfang SHANG, Wenxia ZHAO

2022, 38(11): 2592-2595. DOI: 10.3969/j.issn.1001-5256.2022.11.031

Abstract(483)

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At present, non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases in the world. Recent studies have shown that varying degrees of central nervous system dysfunction can occur during the progression of NAFLD, including cognitive impairment and emotional im...

Effects of antiviral therapy on the reversal of liver fibrosis

Xin LUO, Ying QU, Xiaobo CAI, Lungen LU

2022, 38(11): 2596-2598. DOI: 10.3969/j.issn.1001-5256.2022.11.032

Abstract(1174)

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As an inevitable stage in the progression of various chronic liver diseases, liver fibrosis eventually develops into liver cirrhosis or cancer. Because viral infection is a major cause of liver fibrosis, antiviral therapy is critical in the seroconversion and reversal of liver fibrosis in viral hepa...

Research progress on signal pathways in hepatic fibrosis and targeted regulation mechanisms of active ingredients from traditional Chinese medicine

Wenyan FAN, Junyu HAO, Hongxiu CHEN, Guangwei LIU

2022, 38(11): 2599-2605. DOI: 10.3969/j.issn.1001-5256.2022.11.033

Abstract(703)

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Hepatic fibrosis is a common pathological stage of many chronic liver diseases. Activation of hepatic stellate cells is considered as a key event in the progression of hepatic fibrosis. The pathogenesis of liver fibrosis is modulated by various cytokines involved in several signal pathways, includin...

TIPS for treatment of refractory ascites in cirrhosis

Lanjing WANG, Xin YAO, Jianping QIN, Shanhong TANG

2022, 38(11): 2606-2610. DOI: 10.3969/j.issn.1001-5256.2022.11.034

Abstract(548)

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Refractory ascites (RA) is one of the complications of portal hypertension in decompensated cirrhosis. It is hard to treat RA and there is high mortality in patients with RA. Nowadays, Transjugular Intrahepatic Portosystemic Shunt (TIPS) is used as a second-line treatment for RA. TIPS can improve th...

Mechanism of NLRP3 inflammasome promoting hepatic stellate cell activation

Jing PENG, Wei YUAN, Sihan YIN, Kewei SUN

2022, 38(11): 2611-2615. DOI: 10.3969/j.issn.1001-5256.2022.11.035

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Liver fibrosis is the common result of various chronic liver injuries and can progress to liver cirrhosis and even liver cancer, and at present, there is still no effective means to reverse liver fibrosis. The transformation of activated hepatic stellate cells (HSC) in perisinusoidal space into myof...

Current research status and prospect of circulating tumor DNA in hepatocellular carcinoma

Zhiyuan HOU, Yuan LIU, Chaoran YANG, Jisen ZHAO, Shujie CHENG

2022, 38(11): 2616-2620. DOI: 10.3969/j.issn.1001-5256.2022.11.036

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with the features of insidious onset, low surgical resection rate, and frequent early metastasis and recurrence. With the development of new molecular biology technology in recent years, a liquid biopsy technolog...

Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma

Mengkui HAN, Jin LI, Xiaohua YANG

2022, 38(11): 2621-2626. DOI: 10.3969/j.issn.1001-5256.2022.11.037

Abstract(639)

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As the key immune cells in tumor immune microenvironment, T lymphocytes can affect the proliferation and migration of hepatocellular carcinoma (HCC) cells and control tumor progression through the secretion of cytokines, cytotoxic enzymes (perforin, granzyme B), and other pathways. At the same time,...

Role of signal transducer and activator of transcription 1 in regulation of Treg/Th17 balance in hepatocellular carcinoma

Rui SONG, Jing LI, Hongju YANG, Minyue LI, Jing YOU

2022, 38(11): 2627-2631. DOI: 10.3969/j.issn.1001-5256.2022.11.038

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The regulatory T cells (Treg) and helper T cells 17 (Th17) play an important role in regulation of the tumor microenvironment in hepatocellular carcinoma (HCC) because Treg/Th17 imbalance was associated with HCC cell invasion and progression. Moreover, the suppressor of cytokine signaling 1 (SOCS1),...

Regulatory effect of immune checkpoint TIGIT/CD155 on the immune microenvironment of primary liver cancer and its application prospects

Fan YAO, Xin YIN

2022, 38(11): 2632-2635. DOI: 10.3969/j.issn.1001-5256.2022.11.039

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With the application of immune checkpoint inhibitors in various solid tumors, problems such as drug resistance and poor response gradually occur, and therefore, in order to better improve the prognosis of patients, it is urgent to explore better immunotherapy regimens. This article introduces an eme...

Research advances in traditional Chinese medicine in regulating epithelial-mesenchymal transformation to inhibit hepatocellular carcinoma metastasis

Jue WANG, Chunlei ZHANG, Kaiyue TANG, Peiyong ZHENG, Haiyan SONG

2022, 38(11): 2636-2642. DOI: 10.3969/j.issn.1001-5256.2022.11.040

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Metastasis is an important factor for the high recurrence and mortality rates of hepatocellular carcinoma (HCC), and epithelial-mesenchymal transition (EMT) is an important mechanism of HCC metastasis. EMT is regulated by the transcription factors such as Snail, Twist, and ZEB which are mediated by ...

Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

Yue LIANG, Yonghong HU, Wei LIU, Yongping MU, Jiamei CHEN, Ping LIU

2022, 38(11): 2643-2648. DOI: 10.3969/j.issn.1001-5256.2022.11.041

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End-stage liver disease is the late stage of various acute and chronic liver diseases with high mortality and seriously threatens people's health. Liver transplantation is currently an effective treatment method for this disease, but its clinical application is greatly limited by the factors such as...

Mechanism of action of macrophage polarization in non-neoplastic liver diseases and related targeted therapies

Weiyu CHEN, Xiaobin QIN, Yingyu LE, Han WANG, Xiaorong LONG, Dewen MAO

2022, 38(11): 2649-2653. DOI: 10.3969/j.issn.1001-5256.2022.11.042

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Macrophages, as important immune cells, are involved in the key processes that maintain the homeostasis of intrahepatic microenvironment. Recent studies have shown that different liver diseases can induce macrophage polarization (MPP) and form M1 and M2 phenotypes with mutual antagonism. The former ...

Regulation of hepatocyte polarity

Yuanpeng MAO, Hongshan WEI

2022, 38(11): 2654-2658. DOI: 10.3969/j.issn.1001-5256.2022.11.043

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Hepatocytes are highly polarized cells, and the establishment and maintenance of hepatocyte polarity are critical for the various functions of hepatocytes. The dynamic stability of hepatocyte polarity is associated with various factors including intercellular junctions, polarity complex proteins, an...

The role of competitive endogenous RNA in the development of cholangiocarcinoma

Baolin XU, Yu CHENG, Yong WEI

2022, 38(11): 2659-2662. DOI: 10.3969/j.issn.1001-5256.2022.11.044

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Cholangiocarcinoma is a highly malignant tumor with a poor prognosis, limited treatment options, and complicated pathogenesis. Competitive endogenous RNA is a kind of transcripts that can competitively bind miRNA, including long non-coding RNA and circular RNA. Competitive endogenous RNA is known to...

Molecular mechanism of liver injury in acute pancreatitis

Wenqian XU, Min GUO, Xiao WANG, Yaoqi WU, Jinyuan ZHANG, Heguo LI

2022, 38(11): 2663-2668. DOI: 10.3969/j.issn.1001-5256.2022.11.045

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Acute pancreatitis often progresses rapidly, and if it is not controlled in time, it may lead to multiple organ injury and even death due to organ failure. At present, there is still a high proportion of patients with acute pancreatitis who died due to liver failure. The liver and the pancreas are i...

Correlation of systemic immune-inflammation index and pancreatic cancer prognosis, recent research progress

Faquan ZHOU, Shi CHEN, Hongyu SUN, Lijun TANG

2022, 38(11): 2669-2672. DOI: 10.3969/j.issn.1001-5256.2022.11.046

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Inflammation is associated with cancer development and plays a crucial role in pancreatic cancer progression. Inflammatory cell infiltration in the tumor lesion is a part of the tumor microenvironment, which could promote tumor cell proliferation, invasion, and metastasis. Recently developed systemi...

Introduction of High-quality Articles in Foreign Journals

Journal of Viral Hepatitis｜Reversibility of acute-on-chronic liver failure syndrome in hepatitis B virus-infected patients with and without prior decompensation

2022, 38(11): 2545-2545. DOI: 10.3969/j.issn.1001-5256.2022.11.gwjpwzjj1

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Hepatology｜Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury

2022, 38(11): 2550-2550. DOI: 10.3969/j.issn.1001-5256.2022.11.gwjpwzjj2

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