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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 11
Nov.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(11): 2581-2585

Influencing factors for HBeAg seroconversion in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2022.11.029
  • 1.

    Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China

  • 2.

    Department of Epidemiology, School of Military Preventive Medicine, Air Force Medical University, Xi'an 710032, China

Research funding:

General Program of National Natural Science Foundation of China (81872670)

More Information
  • Corresponding author: HUANG Changxing, 13572133011@163.com(ORCID: 0000-0001-5511-2999)
  • Received Date: 2022-04-30
  • Accepted Date: 2022-06-14
  • Published Date: 2022-11-20
    Abstract
  • HBeAg seroconversion refers to the disappearance of HBeAg and the appearance of anti-HBe in chronic hepatitis B (CHB) patients with positive HBeAg in the past. HBeAg seroconversion marks the reductions in viral replication, immune tolerance, and liver inflammation and is an important monitoring indicator for evaluating disease conditions and the effect of CHB antiviral therapy, and it also indicates the endpoint of satisfactory treatment. Exploring the influencing factors for HBeAg seroconversion is of great significance to the selection of treatment regimens and the prognostic evaluation of CHB patients. This article mainly elaborates on the association of HBV with HBeAg seroconversion in CHB patients from the aspects of virological factors, host genetic factors, drug factors, and immunological factors.

     

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