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CN 22-1108/R
Volume 38 Issue 11
Nov.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(11): 2663-2668

Molecular mechanism of liver injury in acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2022.11.045
  • 1.

    The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China

  • 2.

    Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

Henan Characteristic Backbone Discipline Construction Project of Traditional Chinese Medicine (STG-ZYX02-202116);

Major Special Project of Scientific Research of Traditional Chinese Medicine in Henan Province (2018ZYZD06);

National Natural Science Foundation of China (81904161)

More Information
  • Corresponding author: LI Heguo, lhg1964@163.com(ORCID: 0000-0002-5289-868X)
  • Received Date: 2022-04-05
  • Accepted Date: 2022-05-07
  • Published Date: 2022-11-20
    Abstract
  • Acute pancreatitis often progresses rapidly, and if it is not controlled in time, it may lead to multiple organ injury and even death due to organ failure. At present, there is still a high proportion of patients with acute pancreatitis who died due to liver failure. The liver and the pancreas are interrelated physiologically and affect each other pathologically. This article elaborates on the molecular mechanism of liver injury in acute pancreatitis from the six aspects of the physiological relationship between the pancreas and the liver, cytokines, inflammatory response, oxidative stress, microcirculation disturbance, and intestinal flora translocation.

     

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