| [1] |
FORLANO R, SIGON G, MULLISH BH, et al. Screening for NAFLD-current knowledge and challenges[J]. Metabolites, 2023, 13(4): 536. DOI: 10.3390/metabo13040536. |
| [2] |
KUMAR S, DUAN Q, WU R, et al. Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis[J]. Adv Drug Deliv Rev, 2021, 176: 113869. DOI: 10.1016/j.addr.2021.113869. |
| [3] |
RAZA S, RAJAK S, UPADHYAY A, et al. Current treatment paradigms and emerging therapies for NAFLD/NASH[J]. Front Biosci (Landmark Ed), 2021, 26(2): 206-237. DOI: 10.2741/4892. |
| [4] |
WANG CE, XU WT, GONG J, et al. Research progress in the treatment of non-alcoholic fatty liver disease[J]. Clin J Med Offic, 2022, 50(9): 897-899, 903. DOI: 10.16680/j.1671-3826.2022.09.06. |
| [5] |
LIU GY, SABATINI DM. mTOR at the nexus of nutrition, growth, ageing and disease[J]. Nat Rev Mol Cell Biol, 2020, 21(4): 183-203. DOI: 10.1038/s41580-019-0199-y. |
| [6] |
DELEYTO-SELDAS N, EFEYAN A. The mTOR-autophagy axis and the control of metabolism[J]. Front Cell Dev Biol, 2021, 9: 655731. DOI: 10.3389/fcell.2021.655731. |
| [7] |
SZWED A, KIM E, JACINTO E. Regulation and metabolic functions of mTORC1 and mTORC2[J]. Physiol Rev, 2021, 101(3): 1371-1426. DOI: 10.1152/physrev.00026.2020. |
| [8] |
HAN J, WANG Y. mTORC1 signaling in hepatic lipid metabolism[J]. Protein Cell, 2018, 9(2): 145-151. DOI: 10.1007/s13238-017-0409-3. |
| [9] |
MASUDA M, YOSHIDA-SHIMIZU R, MORI Y, et al. Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes[J]. J Nutr Biochem, 2022, 106: 109017. DOI: 10.1016/j.jnutbio.2022.109017. |
| [10] |
KIM DH, SARBASSOV DD, ALI SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery[J]. Cell, 2002, 110(2): 163-175. DOI: 10.1016/s0092-8674(02)00808-5. |
| [11] |
KOREN I, REEM E, KIMCHI A. DAP1, a novel substrate of mTOR, negatively regulates autophagy[J]. Curr Biol, 2010, 20(12): 1093-1098. DOI: 10.1016/j.cub.2010.04.041. |
| [12] |
WAN W, YOU Z, XU Y, et al. mTORC1 phosphorylates acetyltransferase p300 to regulate autophagy and lipogenesis[J]. Mol Cell, 2017, 68(2): 323-335. e6. DOI: 10.1016/j.molcel.2017.09.020. |
| [13] |
WU W, LI K, GUO S, et al. P300/HDAC1 regulates the acetylation/deacetylation and autophagic activities of LC3/Atg8-PE ubiquitin-like system[J]. Cell Death Discov, 2021, 7(1): 128. DOI: 10.1038/s41420-021-00513-0. |
| [14] |
NNAH IC, WANG B, SAQCENA C, et al. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy[J]. Autophagy, 2019, 15(1): 151-164. DOI: 10.1080/15548627.2018.1511504. |
| [15] |
LI K, WADA S, GOSIS BS, et al. Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3[J]. PLoS Biol, 2022, 20(3): e3001594. DOI: 10.1371/journal.pbio.3001594. |
| [16] |
HOSOKAWA N, HARA T, KAIZUKA T, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy[J]. Mol Biol Cell, 2009, 20(7): 1981-1991. DOI: 10.1091/mbc.e08-12-1248. |
| [17] |
ALERS S, LÖFFLER AS, WESSELBORG S, et al. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks[J]. Mol Cell Biol, 2012, 32(1): 2-11. DOI: 10.1128/MCB.06159-11. |
| [18] |
CHO S, LEE G, PICKERING BF, et al. mTORC1 promotes cell growth via m6A-dependent mRNA degradation[J]. Mol Cell, 2021, 81(10): 2064-2075. e8. DOI: 10.1016/j.molcel.2021.03.010. |
| [19] |
UNO K, YAMADA T, ISHIGAKI Y, et al. A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals[J]. Nat Commun, 2015, 6: 7940. DOI: 10.1038/ncomms8940. |
| [20] |
MUNSON MJ, ALLEN GF, TOTH R, et al. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival[J]. EMBO J, 2015, 34(17): 2272-2290. DOI: 10.15252/embj.201590992. |
| [21] |
YU X, LONG YC, SHEN HM. Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy[J]. Autophagy, 2015, 11(10): 1711-1728. DOI: 10.1080/15548627.2015.1043076. |
| [22] |
HUANG TJ, REN JJ, ZHANG QQ, et al. IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway[J]. Biomed Pharmacother, 2019, 116: 109034. DOI: 10.1016/j.biopha.2019.109034. |
| [23] |
DAN HC, BALDWIN AS. Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt[J]. J Immunol, 2008, 180(11): 7582-7589. DOI: 10.4049/jimmunol.180.11.7582. |
| [24] |
BAR-PELED L, CHANTRANUPONG L, CHERNIACK AD, et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1[J]. Science, 2013, 340(6136): 1100-1106. DOI: 10.1126/science.1232044. |
| [25] |
GOSIS BS, WADA S, THORSHEIM C, et al. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1[J]. Science, 2022, 376(6590): eabf8271. DOI: 10.1126/science.abf8271. |
| [26] |
REIS-BARBOSA PH, MARCONDES-DE-CASTRO IA, MARINHO TS, et al. The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice[J]. Clin Res Hepatol Gastroenterol, 2022, 46(6): 101922. DOI: 10.1016/j.clinre.2022.101922. |
| [27] |
SAIKIA R, JOSEPH J. AMPK: a key regulator of energy stress and calcium-induced autophagy[J]. J Mol Med (Berl), 2021, 99(11): 1539-1551. DOI: 10.1007/s00109-021-02125-8. |
| [28] |
RAMIREZ REYES J, CUESTA R, PAUSE A. Folliculin: A regulator of transcription through AMPK and mTOR signaling pathways[J]. Front Cell Dev Biol, 2021, 9: 667311. DOI: 10.3389/fcell.2021.667311. |
| [29] |
PAQUETTE M, YAN M, RAMÍREZ-REYES J, et al. Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways[J]. Sci Rep, 2021, 11(1): 21268. DOI: 10.1038/s41598-021-99958-7. |
| [30] |
DONG R, ZHANG X, LIU Y, et al. Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease[J]. Phytomedicine, 2023, 112: 154700. DOI: 10.1016/j.phymed.2023.154700. |
| [31] |
LIU R, ZHANG HB, YANG J, et al. Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR[J]. Eur Rev Med Pharmacol Sci, 2018, 22(21): 7500-7508. DOI: 10.26355/eurrev_201811_16291. |
| [32] |
MA N, WANG YK, XU S, et al. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling[J]. Nat Commun, 2021, 12(1): 3059. DOI: 10.1038/s41467-021-23285-8. |
| [33] |
PARK J, RAH SY, AN HS, et al. Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis[J]. Metabolism, 2023, 141: 155516. DOI: 10.1016/j.metabol.2023.155516. |
| [34] |
LI X, GONG H, YANG S, et al. Pectic bee pollen polysaccharide from rosa rugosa alleviates diet-induced hepatic steatosis and insulin resistance via induction of AMPK/mTOR-mediated autophagy[J]. Molecules, 2017, 22(5): 699. DOI: 10.3390/molecules22050699. |
| [35] |
ZHENG W, ZHOU J, SONG S, et al. Dipeptidyl-peptidase 4 inhibitor sitagliptin ameliorates hepatic insulin resistance by modulating inflammation and autophagy in ob/ob mice[J]. Int J Endocrinol, 2018, 2018: 8309723. DOI: 10.1155/2018/8309723. |
| [36] |
CANG X, WANG Y, ZENG J, et al. C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy[J]. Biochem Biophys Res Commun, 2022, 588: 15-22. DOI: 10.1016/j.bbrc.2021.12.018. |
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