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CN 22-1108/R
Volume 39 Issue 8
Aug.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(8): 1977-1982

Research advances in long non-coding small nucleolar RNA host gene in hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.08.032
  • 1.

    Department of Gastroenterology and Hepatology, Clinical Medical College of Tianjin Medical University, Tianjin 300121, China

  • 2.

    Department of Gastroenterology and Hepatology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China

Research funding:

The Natural Science Foundation of Tianjin (19JCZDJC36700)

More Information
  • Corresponding author: HAN Tao, hantaomd@126.com (ORCID: 0000-0003-4216-6968)
  • Received Date: 2022-11-08
  • Accepted Date: 2023-02-20
  • Published Date: 2023-08-20
    Abstract
  • Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is one of the leading causes of cancer-related deaths. Despite the in-depth research on HCC at present, the underlying molecular mechanisms are still unclear. Recent studies have revealed that long non-coding RNAs (lncRNAs) play an important role in the development and progression of HCC, and long non-coding RNA small nucleolar RNA host genes (lncRNA SNHGs) show abnormal expression in HCC and play regulatory roles in the proliferation, invasion, metastasis, angiogenesis, stemness, and drug resistance of tumor cells. This article reviews the mechanism and prognostic value of the lncRNA SNHG family in HCC, so as to provide new ideas for basic and clinical research in this field.

     

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