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Volume 39 Issue 8
Aug.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(8): 1983-1991

Role of circular RNA in the development, progression, diagnosis, and treatment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.08.033

  • Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

Research funding:

The National Natural Science Foundation of China (81700554);

The National Natural Science Foundation of China (82170592)

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  • Corresponding author: FAN Zhiwen, fanzhiwenfff@126.com (ORCID: 0000-0002-3465-4622)
  • Received Date: 2022-10-27
  • Accepted Date: 2022-12-17
  • Published Date: 2023-08-20
    Abstract
  • As the most common type of primary liver cancer, hepatocellular carcinoma (HCC) is an invasive and fatal malignant tumor, and its development and progression involve multiple genes, steps, and stages. Circular RNA (circRNA), as a class of endogenous non-coding RNAs, mainly acts as a sponge by absorbing microRNA or RNA-binding proteins to regulate the expression of downstream target genes. This article comprehensively introduces the role and significance of circRNA in signal transduction, immunity, metabolism, drug resistance, and hepatitis B virus-related HCC and its potential value as a biomarker or therapeutic target for HCC, so as to provide new ideas for the diagnosis and treatment of HCC.

     

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