Hotspots and advances in neoadjuvant therapy for intrahepatic cholangiocarcinoma

Zhiwen LIN; Hongzhi LIU; Yongyi ZENG; Kecan LIN

doi:10.3969/j.issn.1001-5256.2023.09.002

Volume 39 Issue 9

Sep. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(9): 2031-2038

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Hotspots and advances in neoadjuvant therapy for intrahepatic cholangiocarcinoma

DOI: 10.3969/j.issn.1001-5256.2023.09.002

Zhiwen LIN^{1, 2},
Hongzhi LIU^{1, 2},
Yongyi ZENG^{1, 2, 3},
Kecan LIN^{1, 2, 3
,
,
,}

1.
Department of Hepatobiliary Surgery，Mengchao Hepatobiliary Hospital of Fujian Medical University，Fuzhou 350025，China
2.
Liver Disease Research Center of Fujian Province，Fuzhou 350025，China
3.
Department of Hepatobiliary Surgery，The First Affiliated Hospital of Fujian Medical University，Fuzhou 350005，China

Research funding:

‍National Natural Science Foundation of China (62275050);

National Key Research and Development Program (2022YFC2407304);

Fujian Provincial Science and Technology Innovation Joint Fund Project (2019Y9108);

Young Scientific Research Project of Fujian Provincial Health Commission (2021ZQNZD013)

More Information

Corresponding author: LIN Kecan， kclin2002@126.com （ORCID： 0009－0009－9932－7284）
Received Date: 2023-07-06
Published Date: 2023-09-19

Abstract

Abstract

Intrahepatic cholangiocarcinoma （ICC） is a malignant tumor that originates from the epithelial cells of the intrahepatic bile ducts， specifically the secondary and higher branches. The incidence rate of ICC tends to increase significantly worldwide. Due to its insidious onset， atypical clinical symptoms in the early stage， and strong invasiveness， it is often in the advanced stage at the time of diagnosis， which may result in poor prognosis. Radical surgery is the only treatment method to prolong the survival time of patients， but recurrence and metastasis frequently occur after surgery， leading to a low 5－year survival rate. Neoadjuvant therapy refers to the administration of drug treatment or other treatment modalities before surgery to reduce tumor size， lower the risk of recurrence， increase the success rate of surgical resection， or provide better local control for surgery. Currently， there is still no standardized regimens for neoadjuvant therapy， and its potential impact on prognosis remains controversial. This article reviews the hotspots and advances in neoadjuvant therapy for ICC.
- Cholangiocarcinoma,
- Neoadjuvant Therapy,
- Hepatectomy

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References(71)

References

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Hotspots and advances in neoadjuvant therapy for intrahepatic cholangiocarcinoma

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Hotspots and advances in neoadjuvant therapy for intrahepatic cholangiocarcinoma

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