2023 No. 9

2023 NO.9

Theme Issue: Precision Diagnosis and Treatment of Biliary Tumors

Executive Chief Editor: ZENG Yongyi

Mengchao Hepatobiliary Hospital of Fujian Medical University

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Editorial

Precise diagnosis and treatment of biliary tract carcinoma

Ruilin FAN, Zongren DING, Yongyi ZENG

2023, 39(9): 2025-2030. DOI: 10.3969/j.issn.1001-5256.2023.09.001

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Abstract:
‍Biliary tract carcinoma （BTC） is a highly invasive malignant tumor， and its incidence rate has been gradually increasing in recent years. Most patients have lost the opportunity for surgery at the time of diagnosis， and traditional systemic chemotherapy has limited efficacy. In recent years， signif...

Expert Forum

Hotspots and advances in neoadjuvant therapy for intrahepatic cholangiocarcinoma

Zhiwen LIN, Hongzhi LIU, Yongyi ZENG, Kecan LIN

2023, 39(9): 2031-2038. DOI: 10.3969/j.issn.1001-5256.2023.09.002

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Intrahepatic cholangiocarcinoma （ICC） is a malignant tumor that originates from the epithelial cells of the intrahepatic bile ducts， specifically the secondary and higher branches. The incidence rate of ICC tends to increase significantly worldwide. Due to its insidious onset， atypical clinical symp...

Diagnostic and treatment strategies for intrahepatic cholangiocarcinoma in special anatomical locations

Hui XUE, Fengwei LI, Kui WANG

2023, 39(9): 2039-2044. DOI: 10.3969/j.issn.1001-5256.2023.09.003

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The incidence rate of intrahepatic cholangiocarcinoma （ICC） has been increasing significantly in recent years， which has been taken seriously in clinical practice. Compared with hilar and extrahepatic cholangiocarcinoma， ICC tends to have an insidious onset， with clinical symptoms appearing at a lat...

Features of lymph node metastasis and nerve plexus invasion in hilar cholangiocarcinoma and key points for dissection

Lixin ZHANG, Jianjiao ZHU, Gang YANG, Jingdong LI

2023, 39(9): 2045-2048. DOI: 10.3969/j.issn.1001-5256.2023.09.004

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Abstract:
Hilar cholangiocarcinoma is the most common malignant tumor of the biliary tract， and radical surgery is still the only possible means for patients to obtain long－term survival. This article briefly describes the features of lymph node metastasis and nerve plexus invasion in hilar cholangiocarcinoma...

Systemic therapy for gallbladder cancer in the era of precision medicine： Coexistence of opportunities and challenges

Rui ZHANG, Zhimin GENG

2023, 39(9): 2049-2056. DOI: 10.3969/j.issn.1001-5256.2023.09.005

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Abstract:
Gallbladder cancer is the most common malignant tumor of the biliary system， and its treatment outcome is greatly limited by its invasiveness and insensitivity to conventional radiotherapy and chemotherapy. In recent years， the emergence of various high－throughput sequencing techniques has helped to...

Guideline

Chinese expert consensus on robot－assisted choledochal cyst excision in children （2022）

Professional Committee of Pediatric Robotic Surgery, Medical Robotic Surgery Doctor Branch of Chinese Medical Doctor Association & Professional Committee of Maternal and Child Minimally Invasive Surgery, China Maternal and Child Health Association

2023, 39(9): 2074-2080. DOI: 10.3969/j.issn.1001-5256.2023.09.007

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Abstract:
Robotic surgery in children started almost simultaneously with it in adults， but proceeded slowly. Since the Da Vinci robotic choledochal cyst（CC） surgery for children was firstly reported by Woo R et al in 2006， it has been gradually applied in more and more pediatric surgery centers with satisfied...

Key points in AASLD Practice Guidance on Prevention， Diagnosis， and Treatment of Hepatocellular Carcinoma （2023）

Kechun WANG, Mingda WANG, Tian YANG

2023, 39(9): 2081-2086. DOI: 10.3969/j.issn.1001-5256.2023.09.008

Abstract(1583)

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Abstract:
In May 2023， the American Association for the Study of Liver Diseases （AASLD） published AASLD Practice Guidance on Prevention， Diagnosis， and Treatment of Hepatocellular Carcinoma （2023） online. The guidance mainly focuses on the prevention， diagnosis， and treatment of hepatocellular carcinoma （HCC）...

Viral Hepatitis

Familial aggregation transmission of hepatitis B virus infection and influencing factors for outcome

Li LIU, Lixian CHANG, Chunyan MOU, Yingyuan ZHANG, Huimin LI, Yu LUO, Junyi LI, Chunyun LIU

2023, 39(9): 2087-2095. DOI: 10.3969/j.issn.1001-5256.2023.09.009

Abstract(506)

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Objective To investigate the condition of hepatitis B virus （HBV） infection in Yunnan， China， in terms of familial aggregation， risk factors for transmission， and outcome， and to provide strategies for controlling the familial aggregation transmission of HBV. Methods The HBsAg－positive patients who ...

Influencing factors for compliance with hepatocellular carcinoma surveillance in patients with chronic hepatitis B

Meng REN, Junxiu TAO, Ziming LI, Qi HAO, Yi YANG, Yufeng SHI, Yifan LIU, Yue XU, Tongtong ZHENG, Xiaodong LI

2023, 39(9): 2096-2102. DOI: 10.3969/j.issn.1001-5256.2023.09.010

Abstract(388)

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Abstract:
Objective To investigate the influencing factors for compliance with hepatocellular carcinoma （HCC） surveillance in patients with chronic hepatitis B （CHB）. Methods The CHB patients who participated in the clinical study of Hubei Provincial Hospital of Traditional Chinese Medicine from June 2012 to ...

Fatty Liver Disease

Mechanism of growth differentiation factor 11 regulating nonalcoholic fatty liver disease

Tao ZHANG, Xuecui YIN, Feifei REN, Lin DONG, Jia ZHANG, Gaofeng LU

2023, 39(9): 2103-2109. DOI: 10.3969/j.issn.1001-5256.2023.09.011

Abstract(537)

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Objective To investigate the effect of growth differentiation factor 11 （GDF11） on free fatty acid （FFA）－induced hepatocyte steatosis and the role of autophagy in this process. Methods A model of nonalcoholic fatty liver disease was established invitro， and recombinant GDF11 was added to observe its...

Liver Fibrosis and Liver Cirrhosis

Value of traditional noninvasive fibrosis models in diagnosis of significant liver fibrosis in patients with chronic hepatitis B and metabolic associated fatty liver disease

Baisheng HUANG, Lanxin OU, Yingjie ZHANG, Meijie SHI, Sheng LI, Huanming XIAO, Xiaoling CHI

2023, 39(9): 2110-2116. DOI: 10.3969/j.issn.1001-5256.2023.09.012

Abstract(412)

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Objective To investigate the value of traditional noninvasive fibrosis models in the diagnosis of significant liver fibrosis in patients with chronic hepatitis B （CHB） and metabolic associated fatty liver disease （MAFLD）. Methods A total of 499 patients who underwent liver pathological examination i...

Effect of the STING pathway on inflammatory cytokine secretion and phagocytosis by peripheral blood monocytes in patients with hepatitis B cirrhosis

Yifan YANG, Wanwei DU, Xia WANG, Guangde YANG, Li LI, Juanjuan FU, Xiucheng PAN

2023, 39(9): 2117-2121. DOI: 10.3969/j.issn.1001-5256.2023.09.013

Abstract(432)

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Objective To investigate the effect of the STING pathway on the inflammatory cytokine secretion and phagocytosis by peripheral blood monocytes in patients with hepatitis B cirrhosis. Methods Peripheral venous whole blood samples were collected from 35 patients with hepatitis B cirrhosis who were hos...

Risk factors for non－neoplastic portal vein thrombosis in patients with liver cirrhosis

Tianfu LIU, Liang WANG, Lingyi ZHANG

2023, 39(9): 2122-2127. DOI: 10.3969/j.issn.1001-5256.2023.09.014

Abstract(392)

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Objective To investigate the risk factors for non－neoplastic portal vein thrombosis （PVT） in patients with liver cirrhosis and related early predictive factors. Methods A total of 50 cirrhotic patients with non－neoplastic PVT who were hospitalized and treated in Department of Hepatology， The Second ...

Role and mechanism of action of Sanhuang Xiexin Decoction in improving inflammatory injury of brain tissue in rats with hepatic encephalopathy

Ruixi ZHONG, Yuanqin DU, Xiyu XIAO, Wenxuan SONG, Yaobin NONG, Ronghuo ZHU, Jingjing HUANG

2023, 39(9): 2128-2136. DOI: 10.3969/j.issn.1001-5256.2023.09.015

Abstract(657)

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Objective To investigate the role and mechanism of action of Sanhuang Xiexin Decoction in improving inflammatory injury of brain tissue in rats with hepatic encephalopathy （HE） by establishing a rat model of HE. Methods A total of 30 Sprague－Dawley rats were randomly divided into normal group， model...

Other Liver Disease

Disease spectrum of liver disease and its changing trend among inpatients in Nanjing Second Hospital from 2012 to 2021

Zhiyuan XU, Yongfeng YANG

2023, 39(9): 2137-2144. DOI: 10.3969/j.issn.1001-5256.2023.09.016

Abstract(550)

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Abstract:
Objective To investigate the etiology， type， and composition of liver diseases and the changing trend of the composition ratio of different liver diseases among inpatients in Nanjing Second Hospital in the recent ten years. Methods A total of 65 185 inpatients with the primary diagnosis of liver dis...

Effect of dimercaptosuccinic acid combined with zinc sulfate versus D－penicillamine in treatment of children with Wilson’s disease

Xue TIAN, Zhiqiang XU, Yi DONG, Jianguo YAN, Lili CAO, Danni FENG, Yinjie GAO, Shiyou XU, Jingfeng BI, Fuchuan WANG, Min ZHANG

2023, 39(9): 2145-2150. DOI: 10.3969/j.issn.1001-5256.2023.09.017

Abstract(546)

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Objective To investigate the effect of dimercaptosuccinic acid （DMSA） combined with zinc sulfate versus D－penicillamine （DPA） monotherapy in the treatment of children with Wilson’s Disease （WD）， and to provide a reference for clinical medication. Methods A total of 111 children with WD， aged 2－18 ye...

Clinical efficacy of Jiedu Huayu Hushen prescription in treatment of acute－on－chronic liver failure complicated by hepatorenal syndrome

Yanjie LI, Sha WANG, Na WANG, Zhanjin MO, Dewen MAO, Qinglan SHI, Zuhong HUANG, Wenjie BO, Fuli LONG, Kun TANG, Peipei FENG, Min YANG

2023, 39(9): 2151-2157. DOI: 10.3969/j.issn.1001-5256.2023.09.018

Abstract(473)

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Abstract:
Objective To investigate the clinical efficacy of Jiedu Huayu Hushen prescription in the treatment of acute－on－chronic liver failure （ACLF） complicated by hepatorenal syndrome （HRS） and its effect on endotoxemia. Methods Clinical data were collected from 96 patients with ACLF complicated by HRS who ...

Pancreatic Disease

Efficacy and safety of aggressive fluid resuscitation versus conventional fluid resuscitation in early treatment of acute pancreatitis： A Meta－analysis

Zhangpeng WANG, Guangxu JING, Huanhuan LUO, Hongfei DONG, Xuyang WANG, Hongyu SUN, Lijun TANG

2023, 39(9): 2158-2168. DOI: 10.3969/j.issn.1001-5256.2023.09.019

Abstract(492)

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Abstract:
Objective To systematically evaluate the efficacy and safety of aggressive fluid resuscitation versus conventional fluid resuscitation in the early treatment of acute pancreatitis （AP）， and to provide a reference for clinical research and practice. Methods This study was conducted according to PRISM...

Expression and clinical significance of matrix metalloproteinase 7 and heparan sulfate proteoglycan 2 in pancreatic cancer

Jinfeng CHEN, LU Xiaoliu, Xiaoyun ZHANG, Xiping TANG

2023, 39(9): 2169-2174. DOI: 10.3969/j.issn.1001-5256.2023.09.020

Abstract(466)

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Objective To investigate the expression and clinical significance of matrix metalloproteinase 7 （MMP7） and heparan sulfate proteoglycan 2 （HSPG2） in patients with pancreatic cancer. Methods Pancreatic cancer tissue samples， normal adjacent tissue samples， and serum samples were collected from 30 pat...

Case Report

Human immunodeficiency virus infection comorbid with autoimmune hepatitis－primary biliary cholangitis overlap syndrome： A case report

Shixiu PENG, Chunyan LI, Aiping HUANG, Songtao ZHU, Jing MAI, Liping WU

2023, 39(9): 2175-2178. DOI: 10.3969/j.issn.1001-5256.2023.09.021

Abstract(486)

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Acquired immunodeficiency syndrome mainly invades the human immune system and eventually leads to serious defects in human cellular immune function. Autoimmune hepatitis （AIH）－primary biliary cholangitis （PBC） overlap syndrome is a common type of the overlap syndrome of autoimmune liver disease and ...

T－tube flexible ureteroscopy in treatment of residual choledocholithiasis： A case report

Shihong CHEN, Dong WU, Hong WEN, Yuanjun CHEN, Gang CAO

2023, 39(9): 2179-2184. DOI: 10.3969/j.issn.1001-5256.2023.09.022

Abstract(444)

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Abstract:
At present， endoscopic retrograde cholangiopancreatography （ERCP） and T－tube sinus tract lithotomy are the main treatment methods for residual choledocholithiasis after surgery. However， these treatment methods have certain drawbacks； for example， ERCP may cause complications such as postoperative p...

Review

Current research status of primary immune thrombocytopenia with hepatitis B virus infection

Mengzhen HUANG, Yangyang HE, Shixuan WANG

2023, 39(9): 2185-2190. DOI: 10.3969/j.issn.1001-5256.2023.09.023

Abstract(448)

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Primary immune thrombocytopenia （ITP） is an autoimmune disease characterized by increased platelet destruction and impaired production. There is a high incidence rate of hepatitis B virus （HBV） infection in China， and it is often observed in clinical practice that ITP patients are often comorbid wit...

Regulatory role of hypoxia－inducible factor－1α/Yes－associated protein in nonalcoholic fatty liver disease

Hua ZHANG, Xuanxuan KOU, Jingxin DENG, Jiangang ZHANG

2023, 39(9): 2191-2197. DOI: 10.3969/j.issn.1001-5256.2023.09.024

Abstract(630)

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Nonalcoholic fatty liver disease （NAFLD） is the most common chronic liver disease in the world and is closely associated with a variety of metabolic diseases， such as type 2 diabetes， insulin resistance， and cardiovascular and cerebrovascular complications associated with hypertension and dyslipidem...

Research progress of sarcopenia in patients with liver cirrhosis

Xinghui ZHANG, Mengyao ZHENG, Jinhui YANG

2023, 39(9): 2198-2204. DOI: 10.3969/j.issn.1001-5256.2023.09.025

Abstract(831)

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Sarcopenia is a progressive and generalized muscle loss due to aging. With the deepening of research， it is found to be related to many chronic diseases. In patients with liver cirrhosis， owing to reduced protein intake， catabolism imbalance， insufficient self synthesis， and other reasons， the incid...

Association between portal hypertension and malnutrition in liver cirrhosis

Nan GENG, Ming KONG, Yu CHEN, Zhongping DUAN

2023, 39(9): 2205-2209. DOI: 10.3969/j.issn.1001-5256.2023.09.026

Abstract(650)

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The abnormal histological structure of liver cirrhosis leads to the increase in portal venous pressure， and portal hypertension is the main cause of the decompensated events of liver cirrhosis such as ascites， gastroesophageal variceal bleeding， hepatic encephalopathy， and hepatorenal syndrome. Maln...

Association between collateral circulation and gastroesophageal varices in portal hypertension

Lili ZHOU, Chunqing ZHANG

2023, 39(9): 2210-2216. DOI: 10.3969/j.issn.1001-5256.2023.09.027

Abstract(737)

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Collateral circulation is one of the main symptoms of portal hypertension and is the anatomical basis for gastroesophageal varices. This article reviews the anatomical basis and types of collateral circulation and related research advances in the association between collateral circulation and gastro...

A comparative analysis of the hemogram and myelogram of patients with liver cirrhosis and the advantages and disadvantages of splenectomy

Huimin LI, Yizhuo CHEN, Rui ZHAO, Xiao HUANG, Fei HUANG, Huanhuan LI

2023, 39(9): 2217-2224. DOI: 10.3969/j.issn.1001-5256.2023.09.028

Abstract(456)

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Abstract:
Compensated liver cirrhosis （CLC） and decompensated liver cirrhosis （DLC） are the two clinically distinct stages of liver cirrhosis. CLC often has atypical symptoms， while DLC has a variety of clinical manifestations， mainly hypersplenism， i.e.， splenomegaly with abnormal hemogram （reductions in whi...

Research advances in biomarkers for hepatorenal syndrome

Rong SUN, Li JIANG

2023, 39(9): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2023.09.029

Abstract(472)

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Hepatorenal syndrome （HRS） is one of the major complications of end－stage liver cirrhosis and is characterized by reductions in renal blood flow and glomerular filtration rate due to excessive contraction of renal vessels. Although vasoconstrictor combined with human serum albumin is currently used ...

Value of immune－inflammatory factors in predicting intrahepatic cholangiocarcinoma

Guiling LIU, Jie DOU, Huijuan MENG, Bingqi MA

2023, 39(9): 2231-2236. DOI: 10.3969/j.issn.1001-5256.2023.09.030

Abstract(579)

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Abstract:
Intrahepatic cholangiocarcinoma （ICC） is one of the most common primary liver malignancies， with an increasing incidence rate in the past two decades. Surgical resection is the main treatment method for ICC， but more than half of the patients have lost the opportunity for surgery at the time of init...

Role of fecal microbiota transplantation in chronic liver diseases

Hongkai XU, Chunfu WANG, Ye ZHANG, Jianqi LIAN

2023, 39(9): 2237-2243. DOI: 10.3969/j.issn.1001-5256.2023.09.031

Abstract(723)

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Gut microbiota dysbiosis is closely associated with the development， progression， and prognosis of chronic liver diseases， while chronic liver diseases can aggravate gut microbiota dysbiosis， and the two interact with and influence each other. Through transplantation of fecal flora from healthy dono...

Association of copper metabolism disorder with cell damage and liver diseases

Tao LIU, Yali LIU, Feiyu ZHANG, Yanhang GAO

2023, 39(9): 2244-2251. DOI: 10.3969/j.issn.1001-5256.2023.09.032

Abstract(1135)

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Abstract:
Copper is an essential trace element in human body and plays an important role in maintaining health in humans. Copper is involved in various metabolic pathways in human body， and copper metabolism disorder may lead to metabolic disorders such as impaired glucose tolerance and dyslipidemia. The live...

Research advances in ATP－binding cassette transporter G5/8 and cholesterol gallstones

Qin LU, Weihui LIU

2023, 39(9): 2252-2257. DOI: 10.3969/j.issn.1001-5256.2023.09.033

Abstract(373)

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Cholesterol stone is a common type of gallstones and is affected by a variety of controllable and uncontrollable factors. In recent years， extensive studies have been conducted on genetic factors， especially their role in the formation mechanism of cholesterol stones. The ATP－binding cassette family...

Application of traditional Chinese medicine in treatment of pancreatic fibrosis： Clinical strategies and research advances

Xiaodan JI, Biao GONG, Xingjia LI, Chan LYU, Ying XU

2023, 39(9): 2258-2264. DOI: 10.3969/j.issn.1001-5256.2023.09.034

Abstract(929)

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Pancreatic fibrosis is the main irreversible pathological change during the progression of chronic pancreatitis， and at present， there is still a lack of effective drugs for the treatment of pancreatic fibrosis in clinical practice. This article summarizes the application of traditional Chinese medi...

Conference Trends at Home and Abroad

AASLD Congress (2023)

2023, 39(9): 2184-2184. DOI: 10.3969/j.issn.1001-5256.2023.09.gnwhydd1

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Introduction of High - quality Articles in Foreign Journals

Hepatology International｜Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma

2023, 39(9): 2204-2204. DOI: 10.3969/j.issn.1001-5256.2023.09.gwjpwzjj1

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