Disease spectrum of liver disease and its changing trend among inpatients in Nanjing Second Hospital from 2012 to 2021

Zhiyuan XU; Yongfeng YANG

doi:10.3969/j.issn.1001-5256.2023.09.016

Volume 39 Issue 9

Sep. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(9): 2137-2144

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Disease spectrum of liver disease and its changing trend among inpatients in Nanjing Second Hospital from 2012 to 2021

DOI: 10.3969/j.issn.1001-5256.2023.09.016

Zhiyuan XU¹,
Yongfeng YANG^{2
,
,
,}

1.
Nanjing Medical University School of Public Health，Nanjing 211166，China
2.
Department of Hepatology，Teaching Hospital，Nanjing Medical University School of Public Health （Nanjing Second Hospital），Nanjing 210003，China

Research funding:

Jiangsu Province Science and Education Rejuvenation Engineering Key Talent Project (ZDRCC2016013)

More Information

Corresponding author: YANG Yongfeng， yyf1997@163.com （ORCID： 0000－0002－0942－4833）
Received Date: 2022-12-02
Accepted Date: 2023-01-24
Published Date: 2023-09-19

Abstract

Abstract

Objective To investigate the etiology， type， and composition of liver diseases and the changing trend of the composition ratio of different liver diseases among inpatients in Nanjing Second Hospital in the recent ten years. Methods A total of 65 185 inpatients with the primary diagnosis of liver disease were collected in Nanjing Second Hospital from January 2012 to December 2021. Statistical analyses were performed based on the causes and types of liver disease in different years， and composition ratios were calculated. The chi－square test was used for comparison of composition ratio between groups. Results A total of 65 185 patients with liver disease were enrolled， among whom there were 43 110 male patients and 22 075 female patients. Comparison between years showed that as for the type of liver disease， the proportion of patients with liver injury decreased from 55.94% to 46.98% （χ²=282.894， P<0.001）. In terms of etiological distribution， viral hepatitis was still the main etiology， but its composition ratio decreased from 81.65% to 63.22% （χ²=433.919， P<0.001）， and the composition ratio of hepatitis B decreased from 87.09% to 71.96% （χ²=655.893， P<0.001）， while that of hepatitis C increased from 9.67% to 25.22% （χ²=858.840， P<0.001）. The composition ratio of non－viral liver diseases tended to increase， such as drug-induced liver injury， alcoholic liver disease， nonalcoholic fatty liver disease， and autoimmune liver disease. Among the main causes of end－stage liver disease， autoimmune liver disease showed an increasing trend from 2.01% to 11.77% （χ²=459.726， P<0.001）， which should be taken seriously by clinicians. Conclusion There are changes in the composition of main etiologies among inpatients with liver disease in Nanjing Second Hospital in the recent ten years， with the main etiology of viral hepatitis， but its composition ratio tends to decrease， while the composition ratio of non－viral liver disease is gradually increasing.
- Liver Diseases,
- Inpatients,
- Disease Spectrum

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References(22)

References

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Disease spectrum of liver disease and its changing trend among inpatients in Nanjing Second Hospital from 2012 to 2021

DOI: 10.3969/j.issn.1001-5256.2023.09.016