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Volume 39 Issue 9
Sep.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(9): 2237-2243

Role of fecal microbiota transplantation in chronic liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.09.031

  • Department of Infectious Diseases，The Second Affiliated Hospital of Air Force Medical University，Xi’an 710038，China

Research funding:

Shaanxi Province Key Research and Development Plan (2022SF－186)

More Information
  • Corresponding author: LIAN Jianqi， lianjq@fmmu.edu.cn （ORCID： 0000－0002－5549－7590）
  • Received Date: 2022-11-21
  • Accepted Date: 2023-01-02
  • Published Date: 2023-09-19
    Abstract
  • Gut microbiota dysbiosis is closely associated with the development， progression， and prognosis of chronic liver diseases， while chronic liver diseases can aggravate gut microbiota dysbiosis， and the two interact with and influence each other. Through transplantation of fecal flora from healthy donors， fecal microbiota transplantation （FMT） directly reconstructs the intestinal flora of patients and maintains homeostasis， thereby achieving targeted therapeutic outcomes. In recent years， many basic research studies and clinical trials have proved FMT as a core therapeutic strategy for reconstructing intestinal flora and an important breakthrough point in treatment regimens for liver diseases. This article reviews the basic research， clinical studies， and future prospect of FMT in chronic liver diseases.

     

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