| [1] |
TSVETKOV P, COY S, PETROVA B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins[J]. Science, 2022, 375( 6586): 1254－ 1261. DOI: 10.1126/science.abf0529. |
| [2] |
DEV S, KRUSE RL, HAMILTON JP, et al. Wilson disease: update on pathophysiology and treatment[J]. Front Cell Dev Biol, 2022, 10: 871877. DOI: 10.3389/fcell.2022.871877. |
| [3] |
HIMOTO T, MASAKI T. Current trends of essential trace elements in patients with chronic liver diseases[J]. Nutrients, 2020, 12( 7): 2084. DOI: 10.3390/nu12072084. |
| [4] |
HUANG R, CHEN H, LIANG J, et al. Dual role of reactive oxygen species and their application in cancer therapy[J]. J Cancer, 2021, 12( 18): 5543－ 5561. DOI: 10.7150/jca.54699. |
| [5] |
ROCHFORD G, MOLPHY Z, KAVANAGH K, et al. Cu(ii) phenanthroline－phenazine complexes dysregulate mitochondrial function and stimulate apoptosis[J]. Metallomics, 2020, 12( 1): 65－ 78. DOI: 10.1039/c9mt00187e. |
| [6] |
HILTON JB, WHITE AR, CROUCH PJ. Metal－deficient SOD1 in amyotrophic lateral sclerosis[J]. J Mol Med(Berl), 2015, 93( 5): 481－ 487. DOI: 10.1007/s00109－015－1273－3. |
| [7] |
GAŁCZYŃSKA K, DRULIS－KAWA Z, ARABSKI M. Antitumor activity of Pt(II), Ru(III) and Cu(II) complexes[J]. Molecules, 2020, 25( 15): 3492. DOI: 10.3390/molecules25153492. |
| [8] |
SANTORO AM, MONACO I, ATTANASIO F, et al. Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study[J]. Sci Rep, 2016, 6: 33444. DOI: 10.1038/srep33444. |
| [9] |
TSVETKOV P, DETAPPE A, CAI K, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress[J]. Nat Chem Biol, 2019, 15( 7): 681－ 689. DOI: 10.1038/s41589－019－0291－9. |
| [10] |
LI Y. Copper homeostasis: Emerging target for cancer treatment[J]. IUBMB Life, 2020, 72( 9): 1900－ 1908. DOI: 10.1002/iub.2341. |
| [11] |
PARK KC, FOUANI L, JANSSON PJ, et al. Copper and conquer: copper complexes of di－2－pyridylketone thiosemicarbazones as novel anti－cancer therapeutics[J]. Metallomics, 2016, 8( 9): 874－ 886. DOI: 10.1039/c6mt00105j. |
| [12] |
XU J, HUA X, YANG R, et al. XIAP interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion[J]. Oncogenesis, 2019, 8( 12): 71. DOI: 10.1038/s41389－019－0181－8. |
| [13] |
KALITA J, KUMAR V, MISRA UK. A study on apoptosis and anti－apoptotic status in wilson disease[J]. Mol Neurobiol, 2016, 53( 10): 6659－ 6667. DOI: 10.1007/s12035－015－9570－y. |
| [14] |
YANG F, LIAO J, PEI R, et al. Autophagy attenuates copper－induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes[J]. Chemosphere, 2018, 204: 36－ 43. DOI: 10.1016/j.chemosphere.2018.03.192. |
| [15] |
HAZARI Y, BRAVO－SAN PEDRO JM, HETZ C, et al. Autophagy in hepatic adaptation to stress[J]. J Hepatol, 2020, 72( 1): 183－ 196. DOI: 10.1016/j.jhep.2019.08.026. |
| [16] |
POLISHCHUK EV, MEROLLA A, LICHTMANNEGGER J, et al. Activation of autophagy, observed in liver tissues from patients with Wilson disease and from ATP7B－deficient animals, protects hepatocytes from copper－induced apoptosis[J]. Gastroenterology, 2019, 156( 4): 1173－ 1189. DOI: 10.1053/j.gastro.2018.11.032. |
| [17] |
GAO W, HUANG Z, DUAN J, et al. Elesclomol induces copper－dependent ferroptosis in colorectal cancer cells via degradation of ATP7A[J]. Mol Oncol, 2021, 15( 12): 3527－ 3544. DOI: 10.1002/1878－0261.13079. |
| [18] |
LI F, WU X, LIU H, et al. Copper depletion strongly enhances ferroptosis via mitochondrial perturbation and reduction in antioxidative mechanisms[J]. Antioxidants(Basel), 2022, 11( 11): 2084. DOI: 10.3390/antiox11112084. |
| [19] |
GUO H, OUYANG Y, YIN H, et al. Induction of autophagy via the ROS－dependent AMPK－mTOR pathway protects copper－induced spermatogenesis disorder[J]. Redox Biol, 2022, 49: 102227. DOI: 10.1016/j.redox.2021.102227. |
| [20] |
YANG M, WU X, HU J, et al. COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu－Fe balance in hepatocellular carcinoma[J]. J Hepatol, 2022, 76( 5): 1138－ 1150. DOI: 10.1016/j.jhep.2022.01.009. |
| [21] |
CHEN M, ZHENG J, LIU G, et al. Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux[J]. Redox Biol, 2018, 17: 432－ 439. DOI: 10.1016/j.redox.2018.05.013. |
| [22] |
ZISCHKA H, LICHTMANNEGGER J, SCHMITT S, et al. Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease[J]. J Clin Invest, 2011, 121( 4): 1508－ 1518. DOI: 10.1172/JCI45401. |
| [23] |
HAMILTON JP, KOGANTI L, MUCHENDITSI A, et al. Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B(－/－)(Wilson disease) mice[J]. Hepatology, 2016, 63( 6): 1828－ 1841. DOI: 10.1002/hep.28406. |
| [24] |
MEDICI V, SARODE GV, NAPOLI E, et al. mtDNA depletion－like syndrome in Wilson disease[J]. Liver Int, 2020, 40( 11): 2776－ 2787. DOI: 10.1111/liv.14646. |
| [25] |
SHRIBMAN S, POUJOIS A, BANDMANN O, et al. Wilson’s disease: update on pathogenesis, biomarkers and treatments[J]. J Neurol Neurosurg Psychiatry, 2021, 92( 10): 1053－ 1061. DOI: 10.1136/jnnp－2021－326123. |
| [26] |
PFEIFFENBERGER J, MOGLER C, GOTTHARDT DN, et al. Hepatobiliary malignancies in Wilson disease[J]. Liver Int, 2015, 35( 5): 1615－ 1622. DOI: 10.1111/liv.12727. |
| [27] |
van MEER S, de MAN RA, van DEN BERG AP, et al. No increased risk of hepatocellular carcinoma in cirrhosis due to Wilson disease during long－term follow－up[J]. J Gastroenterol Hepatol, 2015, 30( 3): 535－ 539. DOI: 10.1111/jgh.12716. |
| [28] |
YOUNOSSI Z, TACKE F, ARRESE M, et al. Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[J]. Hepatology, 2019, 69( 6): 2672－ 2682. DOI: 10.1002/hep.30251. |
| [29] |
HEFFERN MC, PARK HM, AU－YEUNG HY, et al. In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease[J]. Proc Natl Acad Sci U S A, 2016, 113( 50): 14219－ 14224. DOI: 10.1073/pnas.1613628113. |
| [30] |
TOSCO A, FONTANELLA B, DANISE R, et al. Molecular bases of copper and iron deficiency－associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome[J]. Genes Nutr, 2010, 5( 1): 1－ 8. DOI: 10.1007/s12263－009－0153－2. |
| [31] |
SONG M, SCHUSCHKE DA, ZHOU Z, et al. High fructose feeding induces copper deficiency in Sprague－Dawley rats: a novel mechanism for obesity related fatty liver[J]. J Hepatol, 2012, 56( 2): 433－ 440. DOI: 10.1016/j.jhep.2011.05.030. |
| [32] |
AIGNER E, THEURL I, HAUFE H, et al. Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease[J]. Gastroenterology, 2008, 135( 2): 680－ 688. DOI: 10.1053/j.gastro.2008.04.007. |
| [33] |
TALLINO S, DUFFY M, RALLE M, et al. Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up－regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease[J]. J Nutr Biochem, 2015, 26( 10): 996－ 1006. DOI: 10.1016/j.jnutbio.2015.04.009. |
| [34] |
BUZZETTI E, PARIKH PM, GERUSSI A, et al. Gender differences in liver disease and the drug－dose gender gap[J]. Pharmacol Res, 2017, 120: 97－ 108. DOI: 10.1016/j.phrs.2017.03.014. |
| [35] |
LAN Y, WU S, WANG Y, et al. Association between blood copper and nonalcoholic fatty liver disease according to sex[J]. Clin Nutr, 2021, 40( 4): 2045－ 2052. DOI: 10.1016/j.clnu.2020.09.026. |
| [36] |
STÄTTERMAYER AF, TRAUSSNIGG S, AIGNER E, et al. Low hepatic copper content and PNPLA3 polymorphism in non－alcoholic fatty liver disease in patients without metabolic syndrome[J]. J Trace Elem Med Biol, 2017, 39: 100－ 107. DOI: 10.1016/j.jtemb.2016.08.006. |
| [37] |
EL－RAYAH EA, TWOMEY PJ, WALLACE EM, et al. Both α－1－antitrypsin Z phenotypes and low caeruloplasmin levels are over－represented in alcohol and nonalcoholic fatty liver disease cirrhotic patients undergoing liver transplant in Ireland[J]. Eur J Gastroenterol Hepatol, 2018, 30( 4): 364－ 367. DOI: 10.1097/MEG.0000000000001056. |
| [38] |
YANG JD, HAINAUT P, GORES GJ, et al. A global view of hepatocellular carcinoma: trends, risk, prevention and management[J]. Nat Rev Gastroenterol Hepatol, 2019, 16( 10): 589－ 604. DOI: 10.1038/s41575－019－0186－y. |
| [39] |
BALDARI S, DI ROCCO G, TOIETTA G. Current biomedical use of copper chelation therapy[J]. Int J Mol Sci, 2020, 21( 3): 1069. DOI: 10.3390/ijms21031069. |
| [40] |
DAVIS CI, GU X, KIEFER RM, et al. Altered copper homeostasis underlies sensitivity of hepatocellular carcinoma to copper chelation[J]. Metallomics, 2020, 12( 12): 1995－ 2008. DOI: 10.1039/d0mt00156b. |
| [41] |
PORCU C, ANTONUCCI L, BARBARO B, et al. Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma[J]. Oncotarget, 2018, 9( 10): 9325－ 9343. DOI: 10.18632/oncotarget.24282. |
| [42] |
ZHU J, HUANG S, WU G, et al. Lysyl oxidase is predictive of unfavorable outcomes and essential for regulation of vascular endothelial growth factor in hepatocellular carcinoma[J]. Dig Dis Sci, 2015, 60( 10): 3019－ 3031. DOI: 10.1007/s10620－015－3734－5. |
| [43] |
CHOI J, CHUNG T, RHEE H, et al. Increased expression of the matrix－modifying enzyme lysyl oxidase－like 2 in aggressive hepatocellular carcinoma with poor prognosis[J]. Gut Liver, 2019, 13( 1): 83－ 92. DOI: 10.5009/gnl17569. |
| [44] |
MORISAWA A, OKUI T, SHIMO T, et al. Ammonium tetrathiomolybdate enhances the antitumor effects of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma[J]. Int J Oncol, 2018, 52( 3): 989－ 999. DOI: 10.3892/ijo.2018.4242. |
| [45] |
SINGLA A, CHEN Q, SUZUKI K, et al. Regulation of murine copper homeostasis by members of the COMMD protein family[J]. Dis Model Mech, 2021, 14( 1): dmm045963. DOI: 10.1242/dmm.045963. |
| [46] |
YOSHII J, YOSHIJI H, KURIYAMA S, et al. The copper－chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells[J]. Int J Cancer, 2001, 94( 6): 768－ 773. DOI: 10.1002/ijc.1537. |
| [47] |
REZAEI A, MAHMOODI M, MOHAMMADIZADEH F, et al. A novel copper(II) complex activated both extrinsic and intrinsic apoptotic pathways in liver cancerous cells[J]. J Cell Biochem, 2019, 120( 8): 12280－ 12289. DOI: 10.1002/jcb.28491. |
| [48] |
FANG AP, CHEN PY, WANG XY, et al. Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort[J]. Int J Cancer, 2019, 144( 11): 2823－ 2832. DOI: 10.1002/ijc.31991. |
| [49] |
BAJ J, TERESIŃSKI G, FORMA A, et al. Chronic alcohol abuse alters hepatic trace element concentrations－metallomic study of hepatic elemental composition by means of ICP－OES[J]. Nutrients, 2022, 14( 3): 546. DOI: 10.3390/nu14030546. |
| [50] |
ARAIN SA, KAZI TG, AFRIDI HI, et al. Estimation of copper and iron burden in biological samples of various stages of hepatitis C and liver cirrhosis patients[J]. Biol Trace Elem Res, 2014, 160( 2): 197－ 205. DOI: 10.1007/s12011－014－0058－9. |
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