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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 9
Sep.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(9): 2258-2264

Application of traditional Chinese medicine in treatment of pancreatic fibrosis： Clinical strategies and research advances

DOI: 10.3969/j.issn.1001-5256.2023.09.034
  • 1.

    Department of Gastroenterology，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China

  • 2.

    Teaching and Experiment Center of Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China

Research funding:

National Natural Science Fund for Youth (82004162);

Shanghai Young Science and Technology Talents Sailing Program (20yf1449500);

“Siming Youth Fund” of Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine (SGKJ－201924)

More Information
  • Corresponding author: XU Ying， xuying.911@163.com （ORCID： 0000－0002－4645－3094）
  • Received Date: 2023-01-25
  • Accepted Date: 2023-03-06
  • Published Date: 2023-09-19
    Abstract
  • Pancreatic fibrosis is the main irreversible pathological change during the progression of chronic pancreatitis， and at present， there is still a lack of effective drugs for the treatment of pancreatic fibrosis in clinical practice. This article summarizes the application of traditional Chinese medicine （TCM） in the treatment of pancreatic fibrosis in recent years from the aspects of clinical strategies and research advances. The TCM syndrome differentiation of pancreatic fibrosis involves the liver， gallbladder， spleen， and stomach， and pathological factors are associated with fire， blood stasis， and phlegm dampness. The research on the anti－pancreatic fibrosis effect of TCM extracts mainly involves spleen－strengthening， dampness－resolving， and blood stasis－resolving drugs， and intervention against the activation of pancreatic stellate cells is the main signaling pathway involved in the mechanism of TCM prescriptions in the treatment of pancreatic fibrosis. The above studies provide a reference for in－depth research on the application of TCM in the prevention and intervention of pancreatic fibrosis and the prevention and treatment of related complications.

     

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    The first journal specializing in hepatobiliary and pancreatic diseases in China

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