The definition and pathogenesis of acute－on－chronic liver failure

Xiaogang XIANG; Dabao SHANG; Jinming ZHANG

doi:10.3969/j.issn.1001-5256.2023.10.003

Volume 39 Issue 10

Oct. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(10): 2281-2287

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The definition and pathogenesis of acute－on－chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2023.10.003

Department of Infectious Diseases，Translational Laboratory of Liver Diseases，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200025，China

Research funding:

National Natural Science Foundation of China (82170619);

National Natural Science Foundation of China (81970544);

Program for Young Outstanding Academic Leaders (20XD1422600);

Shanghai Rising Stars of Medical Talent Youth Development Program Outstanding Youth Medical Talents (SHWJRS［2021］－99);

Shanghai talent development fund (2020097);

Shanghai Municipal Key Clinical Specialty (shslczdzk01103)

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Corresponding author: XIANG Xiaogang， shine－xxg@163.com （ORCID： 0000－0003－0999－2950）
Received Date: 2023-07-11
Published Date: 2023-10-30

Abstract

Abstract

The concept of acute－on－chronic liver failure （ACLF） has been widely accepted by scholars around the world since it was proposed nearly 30 years ago， but there are still no uniform criteria for the definition and diagnosis of ACLF worldwide. In recent years， differences have been gradually narrowed and a consensus has been reached in the key features of the disease description for ACLF， such as the underlying chronic liver diseases， acute intrahepatic or extrahepatic injury， acute liver function decompensation， extrahepatic organ failure， high short－term mortality rates， and reversible course of the disease. The pathogenesis of ACLF remains unclear， and most studies focus on systemic inflammatory response and immune dysfunction.
- Acute－On－Chronic Liver Failure,
- Pathologic Processes,
- Systemic Inflammatory Response Syndrome

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References(45)

References

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The definition and pathogenesis of acute－on－chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2023.10.003

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The definition and pathogenesis of acute－on－chronic liver failure

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