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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
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2023 NO.10
Theme Issue：Clinical Typing and Prognostic Evaluation of Acute-on-Chronic Liver Failure
Executive Chief Editor: CHEN Yu
Beijing YouAn Hospital， Capital Medical University
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Editorial
Further discussion on the antiviral treatment of chronic hepatitis B patients with indeterminate phase
Hui ZHUANG
2023, 39(10): 2273-2276. DOI: 10.3969/j.issn.1001-5256.2023.10.001
Abstract(924) HTML (252) PDF (761KB)(268) Cited By (6)
Abstract:
This paper discusses further on the antiviral treatment of chronic hepatitis B patients with indeterminate phase. These patients have a high proportion of significant necroinflammation and fibrosis in the liver， and a higher risk of disease progression compared with those with true HBeAg－positive ch...
Recognition of the clinical classification of acute－on－chronic liver failure： Redefinition from a new perspective of onset manifestations and dynamic outcomes
Jinling DONG, Yu CHEN
2023, 39(10): 2277-2280. DOI: 10.3969/j.issn.1001-5256.2023.10.002
Abstract(763) HTML (310) PDF (522KB)(131) Cited By (7)
Abstract:
Acute－on－chronic liver failure （ACLF） refers to acute liver function decompensation on the basis of chronic liver diseases and is a complex clinical syndrome characterized by organ failure and high short－term mortality. ACLF is reversible and has diverse long－term outcomes and prognoses. The clinica...
Expert Forum
The definition and pathogenesis of acute－on－chronic liver failure
Xiaogang XIANG, Dabao SHANG, Jinming ZHANG
2023, 39(10): 2281-2287. DOI: 10.3969/j.issn.1001-5256.2023.10.003
Abstract(816) HTML (315) PDF (592KB)(209) Cited By (12)
Abstract:
The concept of acute－on－chronic liver failure （ACLF） has been widely accepted by scholars around the world since it was proposed nearly 30 years ago， but there are still no uniform criteria for the definition and diagnosis of ACLF worldwide. In recent years， differences have been gradually narrowed ...
Evolution of the clinical scoring and classification system for acute－on－chronic liver failure
Huimin YIN, Rongkuan LI
2023, 39(10): 2288-2293. DOI: 10.3969/j.issn.1001-5256.2023.10.004
Abstract(540) HTML (306) PDF (578KB)(103) Cited By (2)
Abstract:
Acute－on－chronic liver failure （ACLF） has complex pathogeneses， difficulties in clinical treatment， and poor prognosis. Due to the differences in the distribution of chronic liver diseases in different countries and regions， more than ten scoring and classification systems for ACLF have been propose...
Development of acute－on－chronic liver failure in progressive chronic liver diseases： Risk prediction and stratified management
Tingting QI, Jinjun CHEN
2023, 39(10): 2294-2300. DOI: 10.3969/j.issn.1001-5256.2023.10.005
Abstract(668) HTML (219) PDF (651KB)(95)
Abstract:
Patients with advanced chronic liver disease （ACLD） are hospitalized due to hepatitis， acute decompensation or liver failure and its complications， and they often require stratified management due to different severities. The patients with acute－on－chronic liver failure （ACLF） have the highest short...
Prognostic evaluation of acute－on－chronic liver failure
Qian ZHANG, Tao HAN
2023, 39(10): 2301-2306. DOI: 10.3969/j.issn.1001-5256.2023.10.006
Abstract(617) HTML (129) PDF (570KB)(112)
Abstract:
Acute－on－chronic liver failure （ACLF） is a common clinical syndrome of severe liver disease characterized by a high short－term mortality rate in clinical practice. Therefore， early and accurate evaluation of the prognosis of ACLF patients is of great significance for making clinical decisions and im...
Guideline
Chinese expert consensus on clinical management of hepatopathy－related thrombocytopenia
National Clinical Research Center for Infectious Diseases, Society of Hepatology， Beijing Medical Association, Translational Medicine Branch， Chinese Association of Gerontology and Geriatrics
2023, 39(10): 2307-2320. DOI: 10.3969/j.issn.1001-5256.2023.10.007
Abstract(2884) HTML (1000) PDF (1405KB)(978) Cited By (6)
Abstract:
Hepatopathy－related thrombocytopenia refers to a decrease in platelet count caused by liver disease or its treatment， and the incidence rate of this disease is associated with the course and severity of liver disease. The direct effect of thrombocytopenia on the clinical outcome of patients with liv...
An excerpt of EASL clinical practice guidelines on acute－on－chronic liver failure （2023）
Manman XU, Nan GENG, Yu CHEN
2023, 39(10): 2321-2327. DOI: 10.3969/j.issn.1001-5256.2023.10.008
Abstract(1050) HTML (717) PDF (618KB)(351) Cited By (1)
Abstract:
Acute－on－chronic liver failure （ACLF） is a serious form of acute decompensation of liver cirrhosis， which is characterized by multiple organ failure， systemic inflammatory response， and a high short－term mortality rate. In 2023， the European Association for the Study of the Liver gave recommendation...
An excerpt of EASL clinical practice guidelines on the management of liver diseases in pregnancy （2023）
Guanlun ZHOU, Yuhao JU, Jing XU, Ping ZHANG, Guorong HAN
2023, 39(10): 2328-2335. DOI: 10.3969/j.issn.1001-5256.2023.10.009
Abstract(731) HTML (199) PDF (628KB)(190)
Abstract:
Recently， the European Association for the Study of the Liver organized the development of the clinical practice guidelines for the management of liver diseases in pregnancy， which include 105 recommendations for the clinical management of liver diseases in pregnancy. This article gives an excerpt o...
Excerpt of an international multidisciplinary consensus statement on MAFLD and the risk of CVD （2023）
Xiaodong ZHOU, Na TIAN, Minghua ZHENG
2023, 39(10): 2336-2339. DOI: 10.3969/j.issn.1001-5256.2023.10.010
Abstract(2961) HTML (329) PDF (529KB)(414) Cited By (9)
Abstract:
Metabolic associated fatty liver disease （MAFLD） is a common chronic liver disease around the world， affecting more than a quarter of the adult population worldwide. MAFLD is characterized by the co-occurrence of hepatic steatosis and metabolic disturbance. As a metabolic disorder， MAFLD shares a si...
Liver Fibrosis and Liver Cirrhosis
Mechanism of cytotoxic T lymphocyte－derived exosomes inhibiting hepatic stellate cell activation
Chuanfu QIN, Yali ZHAO, Lijuan LONG, Hua QIU
2023, 39(10): 2340-2347. DOI: 10.3969/j.issn.1001-5256.2023.10.011
Abstract(472) HTML (142) PDF (1118KB)(44) Cited By (1)
Abstract:
Objective To investigate whether cytotoxic T lymphocyte （CTL）－derived exosomes can downregulate HBx expression and inhibit hepatic stellate cell （HSC） activation. Methods The supernatants of HepG2， HepGA14， and CTL cells were collected to extract exosomes， which were referred to as NC－exo， HBV－exo， ...
Therapeutic effect of retention enema with compound rhubarb decoction on a rat model of minimal hepatic encephalopathy based on bile acid metabolomics
Yuanqin DU, Meng WANG, Guochu HUANG, Chun YAO, Ruixi ZHONG, Liangjiang HUANG, Jian XU, Jingjing HUANG, Qinwen TAN, Dewen MAO
2023, 39(10): 2348-2357. DOI: 10.3969/j.issn.1001-5256.2023.10.012
Abstract(440) HTML (169) PDF (1663KB)(38) Cited By (7)
Abstract:
Objective To investigate the therapeutic effect of rhubarb decoction （RD） retention enema on a rat model of minimal hepatic encephalopathy （MHE） and its mechanism of action based on bile acid （BA） metabolomics. Methods A total of 55 male Sprague－Dawley rats were randomly divided into blank group （NC...
Liver Neoplasm
Clinical features of non－B， non－C hepatocellular carcinoma
Shengfang LIU, Liangping LI
2023, 39(10): 2358-2365. DOI: 10.3969/j.issn.1001-5256.2023.10.013
Abstract(466) HTML (184) PDF (668KB)(45)
Abstract:
Objective To investigate the change in the proportion of non－B， non－C hepatocellular carcinoma （NBNC－HCC） in hepatocellular carcinoma， and to compare and analyze the clinicopathological features of NBNC－HCC. Methods A total of 3 090 patients with hepatocellular carcinoma （HCC） who were diagnosed in ...
Effect of synthetic peptide cSN50.1 on the malignant behavior of hepatocellular carcinoma HepG2 cells and its mechanism
Hua XIN, Hongchao SHAN, Haiyan LUAN, Yang RUAN, Xinyan YANG
2023, 39(10): 2366-2374. DOI: 10.3969/j.issn.1001-5256.2023.10.014
Abstract(269) HTML (87) PDF (1783KB)(28)
Abstract:
Objective To investigate the effect of cSN50.1 on the proliferation， migration， invasion， and colony formation of HepG2 cells and its mechanism. Methods HepG2 cells were divided into cSN50.1 0 μmol/L， cSN50.1 10 μmol/L， cSN50.1 30 μmol/L， cSN50.1 50 μmol/L， cSN50.1 70 μmol/L， and cSN50.1 90 μmol/L g...
Other Liver Disease
Acute－on－chronic liver failure： Features and prognosis of a new clinical classification system based on onset manifestations
Yu WU, Jinling DONG, Manman XU, Huina CHEN, Huaibin ZOU, Li BAI, Yu CHEN
2023, 39(10): 2375-2382. DOI: 10.3969/j.issn.1001-5256.2023.10.015
Abstract(579) HTML (232) PDF (901KB)(79) Cited By (4)
Abstract:
Objective To investigate the characteristics of intrahepatic and extrahepatic organ failure at the onset of acute－on－chronic liver failure（ACLF）， to explore the features of a new clinical classification system of ACLF， and to provide a basis for the diagnosis， treatment， prognostic analysis of the d...
Value of peripheral blood lymphocyte count in evaluating the short－term prognosis of patients with acute－on－chronic liver failure
Xiaohua LIU, Shujuan YANG, Yushan LIU, Juan LI, Qiao ZHANG, Yamin WANG, Taotao YAN, Yuan YANG, Yingren ZHAO, Yingli HE
2023, 39(10): 2383-2389. DOI: 10.3969/j.issn.1001-5256.2023.10.016
Abstract(443) HTML (135) PDF (746KB)(50) Cited By (1)
Abstract:
Objective To investigate the influencing factors for the prognosis of patients with acute－on－chronic liver failure （ACLF）， and to establish a short－term prognostic model. Methods A retrospective analysis was performed for the baseline clinical data of 247 patients with ACLF who were hospitalized in ...
Clinical features of bacterial liver abscess in the context of coronavirus disease 2019 in Changchun， China
Yu TIAN, Meili DONG, Yu ZHANG, Diandian HAO, Jialin DU, Xiaoyu WEN
2023, 39(10): 2390-2395. DOI: 10.3969/j.issn.1001-5256.2023.10.017
Abstract(430) HTML (123) PDF (594KB)(24) Cited By (1)
Abstract:
Objective To investigate the clinical and epidemiological features of patients with bacterial liver abscess during the outbreak of coronavirus disease 2019 （COVID－19） in Changchun， China. Methods A retrospective analysis was performed for 37 411 patients who were discharged from The First Hospital o...
Expression and significance of response gene to complement 32 in liver regeneration after partial hepatectomy in mice
Xingyuan LI, Yanfang YANG, Yan CHEN, Wenhui HU, Xiaoying ZHAO, Junming TANG, Deying KONG
2023, 39(10): 2396-2405. DOI: 10.3969/j.issn.1001-5256.2023.10.018
Abstract(708) HTML (114) PDF (3088KB)(57) Cited By (1)
Abstract:
Objective To investigate the expression and role of response gene to complement 32 （RGC32） in liver regeneration after partial hepatectomy （PH）. Methods A total of 42 male C57BL/6 mice， aged 10 weeks， were randomly divided into control group， postoperative day 1 group （1－d group）， postoperative day ...
Biliary Disease
Efficacy and safety of 125I intraluminal irradiation combined with lenvatinib in treatment of progressive extrahepatic cholangiocarcinoma
Xingshu ZHU, Pengfei CHEN, Mengfan ZHANG, Fangzheng LI, Jinwei CHEN, Wenguang ZHANG, Xuhua DUAN, Jianzhuang REN, Xinwei HAN
2023, 39(10): 2406-2412. DOI: 10.3969/j.issn.1001-5256.2023.10.019
Abstract(507) HTML (112) PDF (1005KB)(37) Cited By (1)
Abstract:
Objective To investigate the efficacy and safety of 125I intraluminal irradiation combined with lenvatinib in the treatment of progressive extrahepatic cholangiocarcinoma. Methods A retrospective analysis was performed for 25 patients with progressive extrahepatic cholangiocarcinoma who attended Dep...
Clinical effect of Qingre Lidan granules in preventing the recurrence of choledocholithiasis after laparoscopy combined with choledochoscopy
Jiqiang LI, Qinghui QI, Guixin ZHANG
2023, 39(10): 2413-2420. DOI: 10.3969/j.issn.1001-5256.2023.10.020
Abstract(395) HTML (143) PDF (747KB)(34) Cited By (4)
Abstract:
Objective To investigate the effect of Qingre Lidan granules in preventing the recurrence of choledocholithiasis after laparoscopy combined with choledochoscopy through a retrospective cohort study. Methods A total of 337 inpatients with choledocholithiasis （including those with cholecystolithiasis ...
Efficacy of laparoscopic choledochoscopy combined with holmium laser lithotripsy versus traditional laparotomy in treatment of bile duct stones： A Meta－analysis
Xiangdong NIU, Jing YU, Xuyun WANG, Yifeng CHEN, Shixun MA, Guogan DING, Changfeng MIAO, Xiaopeng WANG, He SU
2023, 39(10): 2421-2431. DOI: 10.3969/j.issn.1001-5256.2023.10.021
Abstract(508) HTML (163) PDF (2044KB)(45) Cited By (1)
Abstract:
Objective To systematically review the efficacy and safety of laparoscopic choledochoscopy combined with holmium laser lithotripsy through a meta－analysis. Methods This study was conducted based on PRISMA guidelines， with a PROSPERO registration number of CRD42023406221. Chinese databases including ...
Pancreatic Disease
Establishment of a modified BISAP scoring system and its clinical significance in the early diagnosis and prognostic evaluation of severe acute pancreatitis
Rongjie LI, Yi PENG, Xiaolong TANG, Decai ZHANG, Shaojun LIU
2023, 39(10): 2432-2442. DOI: 10.3969/j.issn.1001-5256.2023.10.022
Abstract(596) HTML (149) PDF (907KB)(53) Cited By (5)
Abstract:
Objective To establish a modified BISAP scoring system， and to investigate the value of the BISAP scoring system versus the modified BISAP scoring system in assessing the severity and condition of acute pancreatitis （AP）. Methods For the establishment of the new scoring system， a retrospective analy...
Review
Role of heat shock protein 90 in hepatitis B virus replication
Yin HUA, Haili FANG, Shousheng LIU, Yongning XIN, Mei ZHANG, Shiying XUAN
2023, 39(10): 2443-2447. DOI: 10.3969/j.issn.1001-5256.2023.10.023
Abstract(472) HTML (95) PDF (630KB)(40)
Abstract:
Hepatitis B virus （HBV） has the characteristics of wide transmission， a high chronic infection rate， and a low cure rate， and improving the cure rate of HBV may help to improve the long－term prognosis of patients. Heat shock protein 90 （Hsp90） is a chaperone protein widely present in organisms. In r...
Research advances in hepatitis E virus infection in pregnancy
Manhua ZHONG, Jingyue WANG, Yuan HUANG
2023, 39(10): 2448-2453. DOI: 10.3969/j.issn.1001-5256.2023.10.024
Abstract(508) HTML (131) PDF (694KB)(72) Cited By (3)
Abstract:
Previous studies have shown that hepatitis E virus （HEV） infection in pregnancy can cause liver failure and adverse pregnancy outcomes such as miscarriage， stillbirth， and vertical transmission， especially in countries where HEV genotypes 1 and 2 are prevalent. In recent years， HEV infection in Chin...
Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity
Zhaobin CHEN, Liyuan HUANG, Bingyuan WANG, Junping SHI, Jing ZHANG
2023, 39(10): 2454-2459. DOI: 10.3969/j.issn.1001-5256.2023.10.025
Abstract(1130) HTML (148) PDF (961KB)(197) Cited By (12)
Abstract:
There are gradual increases in the incidence rates of metabolic associated fatty liver disease （MAFLD） and type 2 diabetes mellitus （T2DM）， with close relationship and mutual interaction between the two diseases， but the specific mechanism is still unclear. Studies have shown that T2DM and MAFLD may...
Transjugular intrahepatic portosystemic shunt combined with collateral vessel embolization in treatment of gastroesophageal variceal bleeding in liver cirrhosis： Research advances and controversies
Qiong WU, Lianhui ZHAO, Guangchuan WANG, Chunqing ZHANG
2023, 39(10): 2460-2463. DOI: 10.3969/j.issn.1001-5256.2023.10.026
Abstract(490) HTML (76) PDF (506KB)(35) Cited By (4)
Abstract:
Transjugular intrahepatic portosystemic shunt （TIPS） has been recommended as a treatment method for cirrhotic portal hypertension in domestic and foreign guidelines， but there is still uncertainty in its therapeutic efficacy. More and more studies have shown that TIPS combined with collateral vessel...
Recompensation of liver cirrhosis： Current status and challenges
Gong FENG, Juanjuan SONG, Feng YE, Yonghong MA, Yilin REN, Ziyi ZHANG, Na HE, Xueping LI, Man MI
2023, 39(10): 2464-2469. DOI: 10.3969/j.issn.1001-5256.2023.10.027
Abstract(660) HTML (390) PDF (604KB)(162) Cited By (7)
Abstract:
‍Traditionally， the progression from compensated liver cirrhosis to decompensated liver cirrhosis has been considered an irreversible point in the natural history of the disease； however， with the suppression of underlying etiology， cure， and disease regression， this view is challenged by an increas...
Research advances in the role of blood metabolic markers in the treatment response and prognosis prediction of primary liver cancer
Zhiying LIU, Zhihang ZHOU, Song HE
2023, 39(10): 2470-2475. DOI: 10.3969/j.issn.1001-5256.2023.10.028
Abstract(614) HTML (127) PDF (619KB)(63) Cited By (1)
Abstract:
Primary liver cancer is one of the most severe cancer burdens around the world. Metabolic reprogramming is one phenotype of cancer， and blood metabolic markers are closely associated with metabolic reprogramming and can predict the risk of recurrence and survival or assess the treatment response of ...
Research advances in natural drug and food monomers in prevention and treatment of alcoholic liver injury
Jingrong YE, Yan LIN, Hanyi DUAN, Xiaolan REN, Xue YANG, Fengying ZHANG
2023, 39(10): 2476-2484. DOI: 10.3969/j.issn.1001-5256.2023.10.029
Abstract(586) HTML (164) PDF (877KB)(76) Cited By (7)
Abstract:
A large number of data show that the prevalence rate of alcoholic liver injury （ALI） is increasing year by year， and it has become one of the main causes of death due to chronic liver diseases such as liver cancer and liver cirrhosis. Quitting drinking is the main method for the prevention of ALI in...
Advances in the protective mechanism and clinical implications of autophagy in liver failure
Yangyang HU, Xing ZHANG, Yue LUO, Yadong WANG, Caiyan ZHAO
2023, 39(10): 2485-2490. DOI: 10.3969/j.issn.1001-5256.2023.10.030
Abstract(503) HTML (182) PDF (747KB)(61) Cited By (2)
Abstract:
‍Liver failure is a serious clinical syndrome of liver disease with critical condition and high mortality， and besides liver transplantation， there is still a lack of satisfactory radical treatment methods. The pathogenesis of liver failure is complex and remains unclear， involving a variety of fact...
Current research status of biliary stents
Abudula ABUDUKAHAER, Obulkasim HALMURAT, Shaobin DUAN
2023, 39(10): 2491-2496. DOI: 10.3969/j.issn.1001-5256.2023.10.031
Abstract(745) HTML (745) PDF (646KB)(118) Cited By (1)
Abstract:
Biliary tract diseases are a common type of hepatobiliary diseases in China and have a relatively high incidence rate， and related complications are important influencing factors for the health of Chinese patients. Biliary stents are mainly used to alleviate and relieve benign or malignant biliary s...
Research advances in hemorrhage after endoscopic retrograde cholangiopancreatography
Ling FAN, Yan FU, Yi LIU, Hua HUANG, Jing NI, Juan TANG
2023, 39(10): 2497-2505. DOI: 10.3969/j.issn.1001-5256.2023.10.032
Abstract(469) HTML (207) PDF (731KB)(37) Cited By (4)
Abstract:
Although hemorrhage after endoscopic retrograde cholangiopancreatography （ERCP） is mostly mild and self－limited， sometimes blood transfusion and endoscopic hemostasis are still needed. However， rebleeding may occur after conventional endoscopic hemostasis and thus requires interventional vascular em...
Research advances in total pancreatectomy with autologous islet cell transplantation
Jingjing LI, Yuanyu ZHAO, Hong FU, Fei TENG, Jiaxi MAO, Wenyuan GUO
2023, 39(10): 2506-2512. DOI: 10.3969/j.issn.1001-5256.2023.10.033
Abstract(471) HTML (248) PDF (636KB)(34) Cited By (1)
Abstract:
Since the 1970s， patients with chronic pancreatitis （CP） have benefited from total pancreatectomy with autologous islet cell transplantation （TPAIT）. With the continuous development of surgical techniques and perioperative management over the past few decades， there have been improvements in islet c...
Introduction of High - quality Articles in Foreign Journals
Hepatology International｜Messenger RNA electroporated hepatitis B virus (HBV) antigen-specific T cell receptor (TCR) redirected T cell therapy is well-tolerated in patients with recurrent HBV-related hepatocellular carcinoma post-liver transplantation: results from a phase I trial
2023, 39(10): 2431-2431. DOI: 10.3969/j.issn.1001-5256.2023.10.gwjpwzjj1
Abstract(319) HTML (223) PDF (153KB)(26)
Abstract:
Thanks
Current reviewers
2023, 39(10): 2420-2420. DOI: 10.3969/j.issn.1001-5256.2023.10.zhixie1
Abstract(292) HTML (171) PDF (110KB)(21)
Abstract:
    

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