Role of heat shock protein 90 in hepatitis B virus replication

Yin HUA; Haili FANG; Shousheng LIU; Yongning XIN; Mei ZHANG; Shiying XUAN

doi:10.3969/j.issn.1001-5256.2023.10.023

Volume 39 Issue 10

Oct. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(10): 2443-2447

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Role of heat shock protein 90 in hepatitis B virus replication

DOI: 10.3969/j.issn.1001-5256.2023.10.023

Yin HUA^1a,
Haili FANG²,
Shousheng LIU^1b,
Yongning XIN^1a,
Mei ZHANG^{1a
,
,
,},
Shiying XUAN^{1a
,
,
,}

1a.
Department of Infectious Diseases，Qingdao Clinical Medical College Affiliated to Nanjing Medical University，Qingdao Municipal Hospital，Shandong 266011，China
1b.
Clinical Research Center，Qingdao Clinical Medical College Affiliated to Nanjing Medical University，Qingdao Municipal Hospital, Shandong 266011，China
2.
Department of Infectious Diseases，Qingdao Eighth People’s Hospital，Qingdao，Shandong 266000，China

Research funding:

General Project of National Natural Science Foundation of China (32171277)

More Information

Corresponding author: ZHANG Mei， xiangrui20001009@sina.com.cn （ORCID： 0000－0002－3293－0777）; XUAN Shiying， xuansydxy@163.com （ORCID： 0000－0002－9849－1877）
Received Date: 2023-01-17
Published Date: 2023-10-30

Abstract

Abstract

Hepatitis B virus （HBV） has the characteristics of wide transmission， a high chronic infection rate， and a low cure rate， and improving the cure rate of HBV may help to improve the long－term prognosis of patients. Heat shock protein 90 （Hsp90） is a chaperone protein widely present in organisms. In recent years， more and more studies have shown that Hsp90 is associated with HBV infection and plays an important role in HBV replication. It can not only interact with specific proteins of the virus to promote its replication， but also interact with the host’s own proteins to perform its function. This article reviews the role of Hsp90 in HBV replication in recent studies， so as to provide new theoretical guidance and directions for the development of new anti－HBV drugs targeting Hsp90 and the prevention and treatment of HBV infection in the future.
- Hepatitis B Virus,
- HSP90 Heat－Shock Proteins,
- Virus Replication

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References(36)

References

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Role of heat shock protein 90 in hepatitis B virus replication

DOI: 10.3969/j.issn.1001-5256.2023.10.023

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Role of heat shock protein 90 in hepatitis B virus replication

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