Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

Zhaobin CHEN; Liyuan HUANG; Bingyuan WANG; Junping SHI; Jing ZHANG

doi:10.3969/j.issn.1001-5256.2023.10.025

Volume 39 Issue 10

Oct. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(10): 2454-2459

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Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

DOI: 10.3969/j.issn.1001-5256.2023.10.025

1.
School of Clinical Medicine，Jining Medical University，Jining，Shandong 272000，China
2.
Department of Elderly Gastroenterology，The First Affiliated Hospital of China Medical University，Shenyang 110000，China
3.
Department of Liver Diseases，The Affiliated Hospital of Hangzhou Normal University，Hangzhou 310000，China
4.
Department of Gastroenterology，Affiliated Hospital of Jining Medical University，Jining，Shandong 272000，China

Research funding:

‍Project of Medical and Health Technology Development Program in Shandong Province (2019WS366);

PhD Research Foundation of Jining Medical University (2017－BS－007);

Natural Science Foundation of Shandong Province (ZR2019PH068)

More Information

Corresponding author: ZHANG Jing， zhangjing8809@126.com （ORCID： 0000－0003－2502－3156）
Received Date: 2022-12-28
Published Date: 2023-10-30

Abstract

Abstract

There are gradual increases in the incidence rates of metabolic associated fatty liver disease （MAFLD） and type 2 diabetes mellitus （T2DM）， with close relationship and mutual interaction between the two diseases， but the specific mechanism is still unclear. Studies have shown that T2DM and MAFLD may cause aggravation of each other through insulin resistance， inflammation， some hepatocyte factors， and cellular senescence and protect each other through some hepatocyte factors. Further research on the association between T2DM and MAFLD and the mechanism of comorbidity is of great significance for the clinical prevention and treatment of the two diseases.
- Diabetes Mellitus， Type 2,
- Metabolic Associated Fatty Liver Disease,
- Insulin Resistance,
- Inflammation,
- Cytokines,
- Cellular Senescence

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References

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Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

DOI: 10.3969/j.issn.1001-5256.2023.10.025

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Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

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