中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 11
Nov.  2023
Turn off MathJax
Article Contents
Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(11): 2651-2656

Clinical features of portal biliopathy

DOI: 10.3969/j.issn.1001-5256.2023.11.020

  • Department of Hepatology，The First Hospital of Jilin University，Changchun 130000，China

Research funding:

Tianqing Liver Disease Research Fund of China Foundation for Hepatitis Prevention and Control (20210118)

More Information
  • Corresponding author: XU fang， xu_fang@jlu.edu.cn （ORCID： 0000-0001-5159-5989）
  • Received Date: 2023-02-01
  • Accepted Date: 2023-03-17
  • Published Date: 2023-11-28
    Abstract
  •   Objective  This article aims to investigate the clinical features of portal biliopathy （PB） patients， in order to improve the understanding of PB.  Methods  Clinical data were collected from 22 patients who were diagnosed with PB in recent years in The First Hospital of Jilin University， and an analysis was performed for their clinical manifestations， liver function， abdominal color Doppler ultrasound， abdominal CT， and hepatobiliary magnetic resonance imaging. The imaging manifestations of biliary tract abnormalities were described， as well as the type of collateral circulation and the location of thrombosis.  Results  As for the initial symptom in these 22 patients， three were 11 patients with gastrointestinal bleeding， 5 with abdominal distension， 3 with abdominal pain， 1 with fever， 1 with abdominal discomfort， and 1 with gingival bleeding. There were 3 patients with an increase in aspartate aminotransferase， 4 with an increase in alanine aminotransferase， 4 with an increase in gamma-glutamyl transpeptidase， 7 with an increase in alkaline phosphatase， 8 with a reduction in cholinesterase， 9 with a reduction in albumin， 2 with an increase in globulin， and 5 with an increase in total bilirubin. Among the 22 patients， 20 had cavernous transformation of the portal vein， and 2 had portal vein thrombosis without cavernous transformation. All 22 patients had bile duct abnormalities， among whom 2 had extrahepatic bile duct abnormalities alone， 12 had intrahepatic bile duct dilatation alone， and 8 had dilatation of both intrahepatic and extrahepatic bile ducts. Varices at different sites were observed in 20 patients， among whom 19 had esophageal and gastric varices and 1 had peri-gallbladder varices， and no varices was observed in the superior mesenteric vein or the splenic vein.  Conclusion  There are no typical clinical symptoms and changes in liver function parameters in patients with PB， but radiological examination may show dilatation， stenosis， or malformation of the bile ducts at different parts. Therefore， it is necessary to expand the sample size to further explore the diagnosis and treatment of PB.

     

    • FullText(HTML)
  • loading
    • References(21)
  • [1]
    DHIMAN RK, BEHERA A, CHAWLA YK, et al. Portal hypertensive biliopathy[J]. Gut, 2007, 56( 7): 1001- 1008. DOI: 10.1136/gut.2006.103606.
    [2]
    XU F, WEN XY, ZHANG L, et al. Portal ductopathy[J]. Chin J Hepatol, 2014, 22( 11): 871- 873. DOI: 10.3760/cma.j.issn.1007-3418.2014.011.016.

    许芳, 温晓玉, 张磊, 等. 门静脉性胆道病[J]. 中华肝脏病杂志, 2014, 22( 11): 871- 873. DOI: 10.3760/cma.j.issn.1007-3418.2014.011.016.
    [3]
    CHANDRA R, KAPOOR D, THARAKAN A, et al. Portal biliopathy[J]. J Gastroenterol Hepatol, 2001, 16( 10): 1086- 1092. DOI: 10.1046/j.1440-1746.2001.02562.x.
    [4]
    HE ZP, FAN LJ. Diagnosis and treatment of portal biliopathy[J]. Hepatobiliary Pancreat Dis Int, 2002, 1( 4): 581- 586.
    [5]
    JIANG P, WANG SP, LIU YH. A case of portal biliopathy[J]. J Clin Hepatol, 2022, 38( 2): 430- 432. DOI: 10.3969/j.issn.1001-5256.2022.02.034.

    姜朋, 王树鹏, 刘亚辉. 门静脉性胆道病1例报告[J]. 临床肝胆病杂志, 2022, 38( 2): 430- 432. DOI: 10.3969/j.issn.1001-5256.2022.02.034.
    [6]
    SHIN SM, KIM S, LEE JW, et al. Biliary abnormalities associated with portal biliopathy: Evaluation on MR cholangiography[J]. AJR Am J Roentgenol, 2007, 188( 4): W341- W347. DOI: 10.2214/AJR.05.1649.
    [7]
    PANG SJ, YE QW, SHI Y, et al. Progress in clinical diagnosis and treatment of portal hypertensive biliary disease[J]. J Hepatopancreatobiliary Surg, 2015, 27( 5): 431- 433. DOI: 10.11952/j.issn.1007-1954.2015.05.027.

    庞书杰, 叶庆旺, 施洋, 等. 门脉高压性胆病临床诊疗进展[J]. 肝胆胰外科杂志, 2015, 27( 5): 431- 433. DOI: 10.11952/j.issn.1007-1954.2015.05.027.
    [8]
    CHATTOPADHYAY S, NUNDY S. Portal biliopathy[J]. World J Gastroenterol, 2012, 18( 43): 6177- 6182. DOI: 10.3748/wjg.v18.i43.6177.
    [9]
    ITARE VB, IMANIRAD D, ALMAGHRABY A. Portal cholangiopathy: An uncommon cause of right upper quadrant pain[J]. Cureus, 2020, 12( 9): e10281. DOI: 10.7759/cureus.10281.
    [10]
    DHIMAN R, CHAWLA Y, DUSEJA A, et al. Portal hypertensive biliopathy(PHB) in patients with extrahepatic portal venous obstruction(EHPVO)[J]. J Gastroenterol Hepatol, 2006, 21: A222.
    [11]
    TACCHELLA G, GJERMENI O, CRINÓ SF, et al. Portal hypertensive biliopathy and bile duct varices presenting as jaundice[J]. Endoscopy, 2021, 53( 12): E442- E443. DOI: 10.1055/a-1337-1994.
    [12]
    NUNOI H, HIROOKA M, OCHI H, et al. Portal biliopathy diagnosed using color Doppler and contrast-enhanced ultrasound[J]. Intern Med, 2013, 52( 10): 1055- 1059. DOI: 10.2169/internalmedicine.52.8848.
    [13]
    KHUROO MS, RATHER AA, KHUROO NS, et al. Portal biliopathy[J]. World J Gastroenterol, 2016, 22( 35): 7973- 7982. DOI: 10.3748/wjg.v22.i35.7973.
    [14]
    DING HG, OUYANG Y. Clinical manifestations of portal hypertension[J]. Beijing Med J, 2011, 33( 12): 1014- 1017. DOI: 10.15932/j.0253-9713.2011.12.021.

    丁惠国, 欧阳颖. 门脉高压症临床表现[J]. 北京医学, 2011, 33( 12): 1014- 1017. DOI: 10.15932/j.0253-9713.2011.12.021.
    [15]
    OZKAVUKCU E, ERDEN A, ERDEN I. Imaging features of portal biliopathy: Frequency of involvement patterns with emphasis on MRCP[J]. Eur J Radiol, 2009, 71( 1): 129- 134. DOI: 10.1016/j.ejrad.2008.03.007.
    [16]
    BESA C, CRUZ JP, HUETE A, et al. Portal biliopathy: A multitechnique imaging approach[J]. Abdom Imaging, 2012, 37( 1): 83- 90. DOI: 10.1007/s00261-011-9765-2.
    [17]
    WALSER EM, RUNYAN BR, HECKMAN MG, et al. Extrahepatic portal biliopathy: Proposed etiology on the basis of anatomic and clinical features[J]. Radiology, 2011, 258( 1): 146- 153. DOI: 10.1148/radiol.10090923.
    [18]
    KHAN MR, TARIQ J, RAZA R, et al. Portal hypertensive biliopathy: Review of pathophysiology and management[J]. Trop Gastroenterol, 2012, 33( 3): 173- 178. DOI: 10.7869/tg.2012.44.
    [19]
    D’SOUZA SL, DAVENPORT MS, ELTA GH. Biliary stricture secondary to portal biliopathy[J]. Gastrointest Endosc, 2013, 78( 6): 942- 944. DOI: 10.1016/j.gie.2013.07.052.
    [20]
    SEZGIN O, OĞUZ D, ALTINTAŞ E, et al. Endoscopic management of biliary obstruction caused by cavernous transformation of the portal vein[J]. Gastrointest Endosc, 2003, 58( 4): 602- 608. DOI: 10.1067/s0016-5107(03)01975-8.
    [21]
    CHATTOPADHYAY S, GOVINDASAMY M, SINGLA P, et al. Portal biliopathy in patients with non-cirrhotic portal hypertension: Does the type of surgery affect outcome?[J]. HPB, 2012, 14( 7): 441- 447. DOI: 10.1111/j.1477-2574.2012.00473.x.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (287) PDF downloads(43) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[]YesterdayPV[]TodayIP[]TodayPV[]Online[]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return