Clinical features of portal biliopathy

Wenqian GENG; Chong WANG; Hang LI; Junqi NIU; Fang XU

doi:10.3969/j.issn.1001-5256.2023.11.020

Volume 39 Issue 11

Nov. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(11): 2651-2656

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Clinical features of portal biliopathy

DOI: 10.3969/j.issn.1001-5256.2023.11.020

Department of Hepatology，The First Hospital of Jilin University，Changchun 130000，China

Research funding:

Tianqing Liver Disease Research Fund of China Foundation for Hepatitis Prevention and Control (20210118)

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Corresponding author: XU fang， xu_fang@jlu.edu.cn （ORCID： 0000-0001-5159-5989）
Received Date: 2023-02-01
Accepted Date: 2023-03-17
Published Date: 2023-11-28

Abstract

Abstract

Objective This article aims to investigate the clinical features of portal biliopathy （PB） patients， in order to improve the understanding of PB. Methods Clinical data were collected from 22 patients who were diagnosed with PB in recent years in The First Hospital of Jilin University， and an analysis was performed for their clinical manifestations， liver function， abdominal color Doppler ultrasound， abdominal CT， and hepatobiliary magnetic resonance imaging. The imaging manifestations of biliary tract abnormalities were described， as well as the type of collateral circulation and the location of thrombosis. Results As for the initial symptom in these 22 patients， three were 11 patients with gastrointestinal bleeding， 5 with abdominal distension， 3 with abdominal pain， 1 with fever， 1 with abdominal discomfort， and 1 with gingival bleeding. There were 3 patients with an increase in aspartate aminotransferase， 4 with an increase in alanine aminotransferase， 4 with an increase in gamma-glutamyl transpeptidase， 7 with an increase in alkaline phosphatase， 8 with a reduction in cholinesterase， 9 with a reduction in albumin， 2 with an increase in globulin， and 5 with an increase in total bilirubin. Among the 22 patients， 20 had cavernous transformation of the portal vein， and 2 had portal vein thrombosis without cavernous transformation. All 22 patients had bile duct abnormalities， among whom 2 had extrahepatic bile duct abnormalities alone， 12 had intrahepatic bile duct dilatation alone， and 8 had dilatation of both intrahepatic and extrahepatic bile ducts. Varices at different sites were observed in 20 patients， among whom 19 had esophageal and gastric varices and 1 had peri-gallbladder varices， and no varices was observed in the superior mesenteric vein or the splenic vein. Conclusion There are no typical clinical symptoms and changes in liver function parameters in patients with PB， but radiological examination may show dilatation， stenosis， or malformation of the bile ducts at different parts. Therefore， it is necessary to expand the sample size to further explore the diagnosis and treatment of PB.
- Biliary Tract Diseases,
- Ultrasonography， Doppler， Color,
- Magnetic Resonance Imaging,
- Therapeutics

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References

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Clinical features of portal biliopathy

DOI: 10.3969/j.issn.1001-5256.2023.11.020

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Clinical features of portal biliopathy

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