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2023 NO.11

Theme Issue：

Progress in the accurate diagnosis and treatment of hepatitis E Executive

Executive Chief Editor: CAO Hongcui
The First Affiliated Hospital, Zhejiang University School of Medicine
Cover Content

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Editorial
Hepatitis E： From behind the scenes to the front stage
Jian WU, Ze XIANG, Hongcui CAO
2023, 39(11): 2521-2523. DOI: 10.3969/j.issn.1001-5256.2023.11.001
Abstract(598) HTML (138) PDF (532KB)(174) Cited By (2)
Abstract:
Hepatitis E is a type of viral hepatitis caused by hepatitis E virus （HEV） infection. There are four main genotypes of HEV， namely genotypes 1‍ — ‍4. Compared with hepatitis B and hepatitis C， previous research on hepatitis E has made slow progress； however， in recent years， hepatitis E has graduall...
Expert Forum
Advances in the prevention and treatment of the high-risk population for hepatitis E
Yueping ZHU, Chuanwu ZHU
2023, 39(11): 2524-2529. DOI: 10.3969/j.issn.1001-5256.2023.11.002
Abstract(458) HTML (139) PDF (703KB)(87)
Abstract:
Hepatitis E virus （HEV） infection is one of the most common causes of acute viral hepatitis. Most patients with HEV infection are asymptomatic and the virus can be spontaneously eliminated. Pregnant women， the elderly， immunocompromised populations， patients with chronic liver disease， and individua...
The mechanism of the severe exacerbation and chronicity of hepatitis E virus infection
Yuxin CHEN, Yijin WANG
2023, 39(11): 2530-2537. DOI: 10.3969/j.issn.1001-5256.2023.11.003
Abstract(649) HTML (304) PDF (658KB)(113) Cited By (1)
Abstract:
Hepatitis E virus （HEV） infection is the most common cause of acute viral hepatitis worldwide， and over the past ten years， studies have shown that HEV can not only cause acute self-limiting hepatitis， but also lead to severe and chronic infection. Pregnant women or patients with underlying liver di...
Research advances in the interspecies transmission of hepatitis E virus
Yunlong LI, Fen HUANG
2023, 39(11): 2538-2542. DOI: 10.3969/j.issn.1001-5256.2023.11.004
Abstract(402) HTML (173) PDF (562KB)(53) Cited By (2)
Abstract:
Hepatitis E virus （HEV） is a pathogen for viral hepatitis and can be transmitted across species via animals. The incidence rate of hepatitis E caused by HEV infection ranks first among acute viral hepatitis worldwide， and now it has become a major public health issue that threatens human health. In ...
Guideline
Guidelines for integrated traditional Chinese and Western medicine diagnosis and treatment of liver cirrhosis
Chinese Association of Integrative Medicine, Chinese Medical Association
2023, 39(11): 2543-2549. DOI: 10.3969/j.issn.1001-5256.2023.11.005
Abstract(1063) HTML (152) PDF (789KB)(302) Cited By (22)
Abstract:
Liver cirrhosis （LC） is the terminal pathological stage of various chronic liver diseases and is characterized by chronic inflammation， diffuse fibrosis， pseudolobular formation， and portal-systemic collateral circulation， which belongs to the category of jaundice， hypochondriac pain， and abdominal ...
Expert consensus on day-case laparoscopic cholecystectomy
Minimally Invasive Surgery Committee of the Chinese Research Hospital Association
2023, 39(11): 2550-2557. DOI: 10.3969/j.issn.1001-5256.2023.11.006
Abstract(1090) HTML (231) PDF (687KB)(218) Cited By (13)
Abstract:
The concept of day-case surgery was first proposed by British surgeon Nicoll， referring to the surgery or procedure in which a patient completes admission and discharge within one day （24 h）. In recent years， China has gradually implemented the day-case mode of laparoscopic cholecystectomy. Day-case...
Key points of EASL Clinical Practice Guidelines on hepatitis delta virus （2023）
Huimin LIU, Wenting CHEN, Shilian LI, Hongmei GONG, Qing. MAO
2023, 39(11): 2558-2563. DOI: 10.3969/j.issn.1001-5256.2023.11.007
Abstract(723) HTML (255) PDF (1093KB)(209)
Abstract:
Due to significant innovations in the diagnosis and treatment of hepatitis D virus （HDV）， the European Society of Hepatology （EASL） published its first international clinical practice guidelines on the management of individuals with HDV infection in July 2023. The guidelines mainly focus on the six ...
An excerpt of AASLD practice guidance on the use of TIPS， variceal embolization， and retrograde transvenous obliteration in the management of variceal hemorrhage in 2023
Henglu BIAN, Jiasu LI, Cui LIU, Feng LIU
2023, 39(11): 2564-2568. DOI: 10.3969/j.issn.1001-5256.2023.11.008
Abstract(499) HTML (149) PDF (501KB)(133)
Abstract:
A brief introduction of Evidence-based clinical practice guidelines for cholelithiasis 2021 by the Japanese Society of Gastroenterology
Zhenmei CHEN, Jing LIN, Jinhong CHEN
2023, 39(11): 2569-2574. DOI: 10.3969/j.issn.1001-5256.2023.11.009
Abstract(750) HTML (220) PDF (563KB)(180) Cited By (12)
Abstract:
The Japanese Society of Gastroenterology （JSGE） first published evidence-based clinical practice guidelines for cholelithiasis in 2010， followed by a revision in 2016. In April 2023， JSGE published the 2021 edition of evidence-based clinical practice guidelines for cholelithiasis based on the clinic...
Viral Hepatitis
Trend and prediction of the disease burden of acute hepatitis B in China
Huawei QIU, Tianfu LIANG, Zhi ZHONG, Xuejiao JIA, Yang JIANG
2023, 39(11): 2575-2579. DOI: 10.3969/j.issn.1001-5256.2023.11.010
Abstract(601) HTML (144) PDF (604KB)(92) Cited By (3)
Abstract:
Objective To investigate the situation and development trend of the disease burden of acute hepatitis B in China in 1990 — 2019. Methods The Global Burden of Disease 2019 was used to analyze the incidence rate， mortality rate， and disability-adjusted life year （DALY） rate of acute hepatitis B in dif...
Value of albumin-related ratios in predicting the risk of death in patients with hepatitis B virus-related acute-on-chronic liver failure
Yu ZENG, Hang WANG, Cunliang DENG, Yunjiang SHENG
2023, 39(11): 2580-2587. DOI: 10.3969/j.issn.1001-5256.2023.11.011
Abstract(430) HTML (136) PDF (920KB)(48) Cited By (3)
Abstract:
Objective To investigate and compare the value of albumin-related ratios ［total bilirubin-to-albumin ratio （TAR）， creatinine-to-albumin ratio （CAR）， prothrombin time-international normalized ratio-to-albumin ratio （IAR）， neutrophil count-to-albumin ratio （NAR）， and red blood cell distribution width-...
Fatty Liver Disease
ZJU index and the risk of nonalcoholic fatty liver disease in the Uygur population in the rural area of Xinjiang Uygur Autonomous Region： A cohort study
Xiao CHENG, Jiajia WANG, Jing YANG, Rong BAI, Shijie ZHANG, Hongwei ZHANG, Xiangwei WU, Rulin MA, Xianghui ZHANG, Heng GUO, Shuxia GUO, Xinyu PENG
2023, 39(11): 2588-2595. DOI: 10.3969/j.issn.1001-5256.2023.11.012
Abstract(398) HTML (226) PDF (795KB)(30) Cited By (1)
Abstract:
Objective To investigate the association between ZJU index and the onset of nonalcoholic fatty liver disease （NAFLD） in the Uygur population and the value of ZJU index in predicting the risk of NAFLD. Methods The Uighur community of The 51st Regiment of The Third Division of Xinjiang Kashgar Corps w...
Autoimmune Liver Disease
Value of serum complement C3 in the diagnosis of liver fibrosis associated with primary biliary cholangitis
Hui ZHOU, Bin NIU, Yuqiang MI, Yonggang LIU, Ping LI
2023, 39(11): 2596-2606. DOI: 10.3969/j.issn.1001-5256.2023.11.013
Abstract(449) HTML (227) PDF (1065KB)(29) Cited By (2)
Abstract:
Objective To investigate the value of serum complement C3 level in determining the stage of liver fibrosis in primary biliary cholangitis （PBC）. Methods Clinical data were collected from 108 patients with PBC who attended Tianjin Second People’s Hospital and underwent liver biopsy from January 2012 ...
Liver Neoplasm
Diagnostic efficacy of alpha-fetoprotein and alpha-fetoprotein L3% in hepatitis B virus-related early-stage hepatocellular carcinoma
Yuyan TANG, Shibin XIE, Jianyun ZHU
2023, 39(11): 2607-2613. DOI: 10.3969/j.issn.1001-5256.2023.11.014
Abstract(810) HTML (591) PDF (771KB)(51) Cited By (8)
Abstract:
Objective To investigate the diagnostic efficacy and optimal cut-off values of alpha-fetoprotein （AFP） and alpha-fetoprotein variant L3 （AFP-L3） in hepatitis B virus （HBV）-related early-stage hepatocellular carcinoma （HCC）. Methods A total of 1 080 patients with HBV-related HCC （HBV-HCC） who were di...
Value of fibrosis-4 combined with prognostic nutritional index in predicting recurrence and survival time after radiofrequency ablation for early-stage hepatocellular carcinoma
Xu ZHANG, Fushuang HA, Fenghui LI, Yanying GAO, Jing LIANG
2023, 39(11): 2614-2622. DOI: 10.3969/j.issn.1001-5256.2023.11.015
Abstract(929) HTML (195) PDF (1118KB)(36) Cited By (3)
Abstract:
Objective To investigate the value of preoperative fibrosis 4 score （FIB-4） combined with prognostic nutritional index （PNI） in predicting recurrence after radiofrequency ablation （RFA） for early-stage hepatocellular carcinoma （HCC）. Methods A retrospective analysis was performed for the clinical da...
Effect of lysophosphatidic acid on hepatoma cells and related mechanism
Yanying ZHAO, Zhenqi HAN, Yanping ZOU, Yunpeng LI, Tao XU, Liyan LIU, Haitao CHENG
2023, 39(11): 2623-2628. DOI: 10.3969/j.issn.1001-5256.2023.11.016
Abstract(348) HTML (374) PDF (837KB)(14) Cited By (1)
Abstract:
Objective To investigate the expression of lysophosphatidic acid （LPA） in patients with liver cancer， as well as its influence on malignant biological behavior of liver cancer and related regulatory mechanism. Methods From January 2016 to December 2022， 26 patients with liver cancer， 28 patients wit...
Other Liver Disease
The influence of diagnostic criteria of different guidelines on short-term prognosis of artificial liver therapy for acute-on-chronic liver failure
Yuhang CHEN, Zimeng JIANG, Zhijiao ZHANG, Mengyao ZHENG, Meilian WANG, Hua HUANG, Gongfang ZHAO
2023, 39(11): 2629-2634. DOI: 10.3969/j.issn.1001-5256.2023.11.017
Abstract(345) HTML (83) PDF (656KB)(28) Cited By (1)
Abstract:
Objective To investigate the influence of different diagnostic criteria on the short-term prognosis of patients with acute-on-chronic liver failure （ACLF）. Methods A total of 115 ACLF patients who were hospitalized in Department of Gastroenterology， The Second Affiliated Hospital of Kunming Medical ...
Value of MELD 3.0， MELD， and MELD-Na scores in assessing the short-term prognosis of patients with acute-on-chronic liver failure： A comparative study
Beichen GUO, Yuhan LI, Rui CHEN, Lewei WANG, Ying LI, Fang LIU, Manman XU, Yu CHEN, Zhongping DUAN, Shaojie XIN, Tao HAN
2023, 39(11): 2635-2642. DOI: 10.3969/j.issn.1001-5256.2023.11.018
Abstract(636) HTML (303) PDF (824KB)(57) Cited By (3)
Abstract:
Objective To investigate the value of MELD 3.0， MELD， and MELD-Na scores in assessing the 90-day prognosis of patients with acute-on-chronic liver failure （ACLF） through a comparative study. Methods A retrospective analysis was performed for the clinical data of 605 patients with ACLF who were tre...
Effect and mechanism of safranal in a mouse model of sepsis-related liver injury induced by lipopolysaccharide
Yi CHEN, Yifan CHEN, Yichao DU, Peng TAN, Tongxi LI, Junjie BAI, Wenguang FU
2023, 39(11): 2643-2650. DOI: 10.3969/j.issn.1001-5256.2023.11.019
Abstract(475) HTML (423) PDF (1990KB)(48) Cited By (1)
Abstract:
Objective To investigate the protective effect of safranal against sepsis-related liver injury （SRLI） induced by lipopolysaccharide （LPS） in mice and its mechanism. Methods A total of 32 experimental male C57BL/6 mice were divided into control group， single drug group， model group， and treatment gro...
Biliary Disease
Clinical features of portal biliopathy
Wenqian GENG, Chong WANG, Hang LI, Junqi NIU, Fang XU
2023, 39(11): 2651-2656. DOI: 10.3969/j.issn.1001-5256.2023.11.020
Abstract(411) HTML (207) PDF (781KB)(43) Cited By (1)
Abstract:
Objective This article aims to investigate the clinical features of portal biliopathy （PB） patients， in order to improve the understanding of PB. Methods Clinical data were collected from 22 patients who were diagnosed with PB in recent years in The First Hospital of Jilin University， and an analysi...
Efficacy and safety of stereotactic body radiation therapy in treatment of patients with unresectable cholangiocarcinoma
Xiaofang ZHAO, Aimin ZHANG, Wengang LI, Jing SUN, Xiaoyun CHANG, Tao ZHANG, Weiping HE, Xuezhang DUAN
2023, 39(11): 2657-2662. DOI: 10.3969/j.issn.1001-5256.2023.11.021
Abstract(357) HTML (354) PDF (672KB)(25)
Abstract:
Objective To investigate the survival and adverse reactions of patients with unresectable cholangiocarcinoma after stereotactic body radiation therapy （SBRT）. Methods A total of 27 patients with unresectable solitary cholangiocarcinoma without metastasis who underwent SBRT in The Fifth Medical Cente...
Case Report
Transcatheter closure of rare type Ⅱ Abernethy malformation with pulmonary hypertension in children： A case report
Heng ZHANG, Bin JIANG, Zhicheng FANG, Zhongji MENG, Enfu DU
2023, 39(11): 2663-2667. DOI: 10.3969/j.issn.1001-5256.2023.11.022
Abstract(439) HTML (165) PDF (1074KB)(36)
Abstract:
Abernethy malformation， also known as congenital portosystemic shunts， is rare in clinical practice， with less than 300 cases reported in the global literature up to 2019. The disease can have serious complications such as pulmonary hypertension， liver tumor， and liver failure and tends to have an e...
Review
Exploration and practice of the detoxicating， stasis-resolving， and Yang-warming method in reconstructing immune balance in hepatitis B virus-related liver failure
Faming SHU, Ying HUANG, Dewen MAO
2023, 39(11): 2668-2673. DOI: 10.3969/j.issn.1001-5256.2023.11.023
Abstract(361) HTML (98) PDF (1008KB)(21) Cited By (2)
Abstract:
Liver failure is an acute and critical disease in the field of liver diseases， and liver failure in China is mainly caused by hepatitis B virus （HBV） infection. Professor Mao Dewen has made remarkable achievements in the prevention and treatment of HBV-related liver failure in basic and clinical res...
Haematological diseases associated with Hepatitis E virus infection
Min LI, Fuwen XIA, Jiankun LIU
2023, 39(11): 2674-2681. DOI: 10.3969/j.issn.1001-5256.2023.11.024
Abstract(469) HTML (107) PDF (699KB)(32)
Abstract:
Hepatitis E virus （HEV） infection can cause acute， fulminant， and chronic hepatitis and is thus a worldwide health problem. The general population has no obvious symptoms or only mild symptoms after HEV infection， and most symptoms are self-limited and are easily ignored in clinical diagnosis. Previ...
Bidirectional relationship between nonalcoholic fatty liver disease and sarcopenia： New insights and perspectives
Gong FENG, Yilin REN, Yonghong MA, Tianyue WU, Jiayi ZHANG, Xiaoni YAN, Juanjuan SONG, Xueping LI, Man MI
2023, 39(11): 2682-2688. DOI: 10.3969/j.issn.1001-5256.2023.11.025
Abstract(472) HTML (285) PDF (728KB)(36) Cited By (2)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is a group of highly heterogeneous diseases closely associated with metabolic dysfunction. Sarcopenia is a syndrome caused by a continuous decline in muscle mass， strength， and function， and it is often accompanied by NAFLD. Insulin resistance is the main pat...
Research advances in noninvasive diagnosis of liver fibrosis in autoimmune liver diseases
Xiaohan MA, Lixia YANG
2023, 39(11): 2689-2696. DOI: 10.3969/j.issn.1001-5256.2023.11.026
Abstract(490) HTML (170) PDF (646KB)(57) Cited By (3)
Abstract:
Autoimmune liver diseases （ALD） are a group of chronic inflammatory liver diseases mediated by autoimmune response and can progress to liver fibrosis， liver cirrhosis， and even liver failure. Early diagnosis， early treatment， and dynamic follow-up of liver fibrosis in ALD may help to improve the pro...
Neoadjuvant therapy for hepatocellular carcinoma： Current situation and prospects
Zhisong NI, Junhan WEN, Weiwei ZHAO, Shoujun YU, Liang HAO, Yu CHENG, Xin LIU
2023, 39(11): 2697-2704. DOI: 10.3969/j.issn.1001-5256.2023.11.027
Abstract(894) HTML (309) PDF (751KB)(97) Cited By (6)
Abstract:
Hepatocellular carcinoma （HCC） is a major cause of cancer-related death， and surgical resection remains an important method for radical treatment， but it is urgently needed to solve the problem of high postoperative recurrence rate. Neoadjuvant therapy can reduce the high recurrence rate after surge...
Predictive indicators for the efficacy of targeted therapy/immunotherapy for hepatocellular carcinoma
Pengwei REN, Ying HAN, Xinmin ZHOU
2023, 39(11): 2705-2709. DOI: 10.3969/j.issn.1001-5256.2023.11.028
Abstract(623) HTML (216) PDF (549KB)(64) Cited By (2)
Abstract:
Hepatocellular carcinoma （HCC） is a common malignancy in China， and molecular-targeted drugs and immune checkpoint inhibitors for the treatment of advanced HCC are currently a research hotspot； however， there are large individual differences in the treatment outcome of advanced HCC. In order to furt...
Gut-liver axis： Intestinal microbial homeostasis and hepatocellular carcinoma
Quan ZHOU, Chunlin CAI, Jinqiang LI
2023, 39(11): 2710-2717. DOI: 10.3969/j.issn.1001-5256.2023.11.029
Abstract(992) HTML (404) PDF (811KB)(56) Cited By (6)
Abstract:
Intestinal microbiota plays an important role in maintaining liver metabolic homeostasis and affects the development and progression of hepatocellular carcinoma by participating in bile acid metabolism. Gut-liver axis plays an important role in the pathogenesis of liver diseases， and it might be one...
Current research status of traditional Chinese medicine in the prevention and treatment of hepatocellular carcinoma by regulating the JAK/STAT signaling pathway
Xing YANG, Shudi LI, Jiangkai LIU, Zhen WANG, Suling LI
2023, 39(11): 2718-2729. DOI: 10.3969/j.issn.1001-5256.2023.11.030
Abstract(729) HTML (537) PDF (815KB)(41) Cited By (4)
Abstract:
Hepatocellular carcinoma （HCC） is one of the common malignant tumors of the digestive tract and seriously threatens the life of patients due to a high incidence rate， a high degree of malignancy， strong invasion and metastasis， and poor prognosis. At present， the main methods for the prevention and ...
The physiological and pathological role of amyloid protein in the liver
Yekai ZONG, Jiangkai LIU
2023, 39(11): 2730-2737. DOI: 10.3969/j.issn.1001-5256.2023.11.031
Abstract(532) HTML (205) PDF (645KB)(36) Cited By (1)
Abstract:
Amyloid protein （AP） is used to describe the fibrous aggregates that form when proteins are misfolded， and it is associated with a series of amyloidosis diseases. When AP is deposited in the liver， it will lead to liver amyloidosis， thereby inducing related pathological changes that affect the norma...
Advances in the diagnosis and treatment of gallbladder carcinoma
Yi LE, Hao YANG, Hu LIU, Zhaoyang CUI, Xiangning ZHAO, Liang AN, Haizhu LI, Shaogeng ZHANG
2023, 39(11): 2738-2744. DOI: 10.3969/j.issn.1001-5256.2023.11.032
Abstract(1013) HTML (867) PDF (868KB)(295) Cited By (4)
Abstract:
Gallbladder carcinoma is a common malignant tumor of the biliary system characterized by poor specificity of early symptoms， a high degree of malignancy， and rapid progression， and it is difficult to make an early diagnosis. Gallstones and gallbladder polyps are considered the most common risk facto...
Introduction of High - quality Articles in Foreign Journals
Journal of Gastroenterology and Hepatology｜Farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis
2023, 39(11): 2523-2523. DOI: 10.3969/j.issn.1001-5256.2023.11.gwjpwzjj1
Abstract(228) HTML (96) PDF (903KB)(25)
Abstract:
Thanks
Current reviewers
2023, 39(11): 2595-2595. DOI: 10.3969/j.issn.1001-5256.2023.11.zhixie1
Abstract(188) HTML (104) PDF (878KB)(11)
Abstract:
    

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