Bidirectional relationship between nonalcoholic fatty liver disease and sarcopenia： New insights and perspectives

Gong FENG; Yilin REN; Yonghong MA; Tianyue WU; Jiayi ZHANG; Xiaoni YAN; Juanjuan SONG; Xueping LI; Man MI

doi:10.3969/j.issn.1001-5256.2023.11.025

Volume 39 Issue 11

Nov. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(11): 2682-2688

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Bidirectional relationship between nonalcoholic fatty liver disease and sarcopenia： New insights and perspectives

DOI: 10.3969/j.issn.1001-5256.2023.11.025

Gong FENG^{1a, 2},
Yilin REN^1b,
Yonghong MA^1c,
Tianyue WU^1b,
Jiayi ZHANG^1d,
Xiaoni YAN^1c,
Juanjuan SONG^1c,
Xueping LI^{1e
,
,
,},
Man MI^{1a
,
,
,}

1a.
Institute of General Practice，Xi’an Medical University，Xi’an 710021，China
1b.
School of General Practice，Xi’an Medical University，Xi’an 710021，China
1c.
School of Public Health，Xi’an Medical University，Xi’an 710021，China
1d.
School of Medical Technology，Xi’an Medical University，Xi’an 710021，China
1e.
School of Clinical Medicine，Xi’an Medical University，Xi’an 710021，China
2.
Department of Infection，The First Affiliated Hospital of Xi’an Jiaotong University，Xi’an 710061，China

Research funding:

‍Key Projects of Shaanxi Provincial Department of Education-Key Experimental Category (21JZ050);

Project of Provincial Department of Science and Technology (2022-JQ-986);

Research Projects of Xi’an Medical University at University Level in 2021 (2021QN20)

More Information

Corresponding author: LI Xueping， lxp86@163.com （ORCID： 0000-0002-0556-9728）; MI Man， 853002274@qq.com （ORCID： 0000-0001-7408-5113）
Received Date: 2023-04-24
Accepted Date: 2023-06-01
Published Date: 2023-11-28

Abstract

Abstract

Nonalcoholic fatty liver disease （NAFLD） is a group of highly heterogeneous diseases closely associated with metabolic dysfunction. Sarcopenia is a syndrome caused by a continuous decline in muscle mass， strength， and function， and it is often accompanied by NAFLD. Insulin resistance is the main pathological mechanism for sarcopenia and NAFLD， and in addition， factors such as changes in proteins and branched‍-‍chain amino acid， hyperammonemia， intestinal flora， and endocrine dysfunction can also lead to sarcopenia and NAFLD. With the deepening of clinical research， many published prospective studies have confirmed the existence of a bidirectional and complex pathophysiological relationship between sarcopenia and NAFLD. This article reviews the bidirectional relationship between sarcopenia and NAFLD， discusses the common pathogenesis of sarcopenia and NAFLD， summarizes the challenges faced in this field， and proposes new directions for the research on the bidirectional relationship between NAFLD and sarcopenia.
- ‍Sarcopenia,
- Non-alcoholic Fatty Liver Disease,
- Therapeutics

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References(46)

References

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Bidirectional relationship between nonalcoholic fatty liver disease and sarcopenia： New insights and perspectives

DOI: 10.3969/j.issn.1001-5256.2023.11.025

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Bidirectional relationship between nonalcoholic fatty liver disease and sarcopenia： New insights and perspectives

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