HIV/HCV重叠感染患者病情进展的相关因素研究

To discuss the reason of disease progression in HIV/HCV co-infected patients. Retrospective study was designed to analysis the immunological function, HIV-RNA Viralload liver function and prognosis in HIV/HCV co-infected patients. According to the disease progression, the patients are divided into two groups: AIDS group and free of AIDS group. The difference of immunological function, liver function in groups was performed statistics analysis. Immunological function (CD + 4T, CD + 8T) are lower in AIDS group than in free of AIDS group (P<0.001;P=0.003) , HIV-RNA viral load is higher in AIDS group than in free of AIDS group (P=0.005) . In the aspect of liver function alanine and aspartate aminotramsferase (ALT, AST) are higher in AIDS group than in free of AIDS group (P=0.043;P=0.002) . Total protein (TP) and albumin (ALB) are lower in AIDS group than in free of AIDS group (P<0.001) . Logistic analysis predicts that CD + 4T, duration of HCV infection and ALB are independent risk factors (P<0.001) . Predicted percentage of correct is 97.0%. HIV/HCV co-infection effect each other, increasing the disease progression. Albumin, CD + 4T cell and duration of HCV infection are independent risk factors of AIDS progression.