To study the causes of accelerating liver function failure in the patients with HIV/HCV coinfection. The patients were divided into two groups, HIV/HCV coinfection group (n=82) and simple HCV infection group (n=62) . A retrospective study was designed to compare liver function, pathology of liver tissue, the time of infection, immune function, qualitative assay of HCV-RNA and HCV antibody between the two groups. Although there was significant difference between two groups on liver function (P<0.05) , but there were no significant differences in degree of inflammation of liver and degree of liver fibrosis in the two groups (P=0.187, 0.954) . However, the time when liver abnormality occurred in the patients with HIV/HCV coinfection was earlier 8 years than those with simple HCV infection (P<0.001) .There were significant differences between the two groups on the count of CD + 4T and CD + 8T (P<0.001, P<0.001) .Comparing the cases of HCVRNA (+) and anti-HCV (+) with the cases of HCVRNA (+) and anti-HCV (-) , we found that the ratio was 52 to 9 in the group of HIV/HCV coinfection, and 44 to 1 in the group of simple HCV infection. The difference was statistically significant between the two groups (P=0.043) . HIV/HCV coinfection can accelerate deterioration of hepatitis C, which maybe due to the effect of HIV on cellular immunity and humoral immunity.
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