中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2006

S100A4和E-Cadherin在胰腺癌组织中的表达及相关性研究

  • Published Date: 2006-03-20
  • To investigate the relationship between S100A4 and E-Cadherin expression in the pancreatic cancer and their correlation with tumor invasion and metastasis.Immunohistochemistry was used to detect the expression of S100A4 and E-Cadherin in the tissue microarray constructed with 168 cases of pancreatic cancers.The positive expression of S100A4 and E-Cadherin in the cancer tissue were 82.74% (139/168) and 65.4% (110/168) respectively.S100A4 expression rate was 9.8% (10/102) in tissue and was 57% (4/7) in mucinous cystic adenoma.E-Cadherin expressed in all the Para-tumor tissue and normal pancreas, but only 30% (2/7) expressed in mucinous cystic adenoma.The expression of S100A4 and E-Cadherin had a closely relation in pancreatic cancer.S100A4 always overexpresses in the pancreatic ductal carcinoma and reflects the invasion and lymphomatic metastasis of tumors.It also is related with the down-regulation of E-Cadherin.

     

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