Expression of Plk1 and Survivin in hepatocellular carcinoma and its significance

Liu QiSheng; Xu XiaoHong; Liu Huai

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Apr. 2011

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Article Navigation > Journal of Clinical Hepatology > 2011 > 27(4): 397-399

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Expression of Plk1 and Survivin in hepatocellular carcinoma and its significance

Received Date: 2010-08-19
Published Date: 2011-04-20

Abstract

Abstract

Objective Investigating expression of Plk1 and survivin in hepatocellular carcinoma.providing theory for diagnosis and therapy in clinic.Methods Immunohistochemical analysis was used to detect the expression of Plk1 and Survivin in 100 cases of hepatocellular carcinoma.Results ⑴The positive rate of survivin expression in HCC was significantly higher than that in normol liver tissues (P<0.05) .There was no correlation between the expression of Survivin with patient gender, age, tumor differentiation, AFP and whether the violations were not associated with the liver capsule. (P>0.05) There was correlation between the expression of Survivin with the expression of HBsAg (P<0.05) .⑵The positive rate of Plk1 expression in HCC was significantly higher than that in normol liver tissues (P<0.05) .There was no correlation between the expression of Plk1 with patient's gender, age, AFP, HBsAg and whether the violations were not associated with the liver capsule (P>0.05) .There was correlation between the expression of Survivin with the tumor differentiation (P<0.05) .⑶Plk1 was positively correlated with Survivin expression in hepatocellular carcinoma (P<0.05) .Conclusion Detection of the Survivin and Plk1 can supply certain evidence on prognosis and treatment of hepatocellular cancer.
- carcinoma,
- hepatocellular,
- gene expression,
- mitogen-activated protein kinases

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Expression of Plk1 and Survivin in hepatocellular carcinoma and its significance

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