中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2011

Biomarkers of liver cancer related to hepatitis B virus selected by proteomics

Research funding:

 

  • Published Date: 2011-05-20
  • Hepatocellular carcinoma (HCC) is one of the most deadly malignancies worldwide.Hepatitis B virus (HBV) is widely recognized as one of the major etiological factors of HCC.However, the mechanism of liver cancer related to HBV infection is still unclear.Liver cancer is difficult to detect in an early stage.Proteomics has caused researcher's wide attention due to its complementary to other research methods in liver cancer study.Herein, we review the latest three year developments in the studies of proteomics applied to liver cancer related to HBV infection, to summarize the diagnosis biomarkers and cancerization mechanism of liver cancer related to HBV infection.

     

  • [1]Cabibbo G, Craxi A.Epidemiology, risk factors and surveillance of hepatocellular carcinoma[J].Eur Rev Med Pharmacol Sci, 2010, 14 (4) :352-355.
    [2]Lopez JB.Recent developments in the first detection of hepatocellular carcinoma[J].Clin Biochem Rev, 2005, 26 (3) :65-79.
    [3]Gomaa AI, Khan SA, Leen EL, et al.Diagnosis of hepatocellular carcinoma[J].World J Gastroenterol, 2009, 15 (11) :1301-1314.
    [4]Chen X, Jorgenson E, Cheung ST.New tools for functional genomic analysis[J].Drug Discov Today, 2009, 14 (15-16) :754-760.
    [5]Rousseau D, Khochbin S, Gorka C, et al.Induction of H1 (0) -gene expression in B16 murine melanoma cells[J].Eur J Biochem, 1992, 208 (3) :775-779.
    [6]Baltimore D.Our genome unveiled[J].Nature, 2001, 409 (6822) :814-816.
    [7]Zhang L, Peng X, Zhang Z, et al.Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis[J].J Cell Biochem, 2010, 110 (1) :219-228.
    [8]Saito Y, Oba N, Nishinakagawa S, et al.Identification of beta2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis[J].Oncol Rep, 2010, 23 (5) :1325-1330.
    [9]Li WH, Miao XH, Qi ZT, et al.Proteomic analysis of differently expressed proteins in human hepatocellular carcinoma cell lines HepG2 with transfecting hepatitis B virus X gene[J].Chin Med J (Engl) , 2009, 122 (1) :15-23.
    [10]Lee NP, Chen L, Lin MC, et al.Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma[J].J Proteome Res, 2009, 8 (3) :1293-1303.
    [11] Zubaidah RM, Tan GS, Tan SB, et al.2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver临床肝胆病杂志2011年第27卷第5期carcinogenesis[J].Proteomics, 2008, 8 (23-24) :5086-5096.
    [12]Tong A, Wu L, Lin Q, et al.Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model[J].Proteomics, 2008, 8 (10) :2012-2023.
    [13]Li N, Long Y, Fan X, et al.Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues[J].J Exp Clin Cancer Res, 2009, 28 (1) :122.
    [14]Steel LF, Shumpert D, Trotter M, et al.A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma[J].Proteomics, 2003, 3 (5) :601-609.
    [15]Sun S, Lee NP, Poon RT, et al.Oncoproteomics of hepatocellular carcinoma:from cancer markers'discovery to functional pathways[J].Liver Int, 2007, 27 (8) :1021-1038.
    [16]Lee A, Chick JM, Kolarich D, et al.Liver membrane proteome glycosylation changes in mice bearing an extra-hepatic tumour[J].Mol Cell Proteomics, 2010.
    [17]Wilson B, Liotta LA, Petricoin E, 3rd.Monitoring proteins and protein networks using reverse phase protein arrays[J].Dis Markers, 2010, 28 (4) :225-232.
    [18]Tao SC, Chen CS, Zhu H.Applications of protein microarray technology[J].Comb Chem High Throughput Screen, 2007, 10 (8) :706-718.
    [19]Kim S, Lee D.Mining metastasis related genes by primary-secondary tumor comparisons from large-scale databases[J].BMC Bioinformatics, 2009, 10 (Suppl 3) :S2.
    [20]Sun W, Zhong F, Zhi L, et al.Systematic-omics analysis of HBV-associated liver diseases[J].Cancer Lett, 2009, 286 (1) :89-95.
    [21]Block TM.Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans[J].Proceedings of the National Academy of Sciences, 2005, 102 (3) :779-784.
    [22]Feng JT, Liu YK, Song HY, et al.Heat-shock protein 27:a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis[J].Proteomics, 2005, 5 (17) :4581-4588.
    [23]Lim SO, Park SJ, Kim W, et al.Proteome analysis of hepatocellular carcinoma[J].Biochem Biophys Res Commun, 2002, 291 (4) :1031-1037.
    [24]Sun S, Poon RT, Lee NP, et al.Proteomics of hepatocellular carcinoma:serum vimentin as a surrogate marker for small tumors (
    [25]Na K, Lee EY, Lee HJ, et al.Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma[J].Proteomics, 2009, 9 (16) :3989-3999.
    [26]Yeo M, Na YM, Kim DK, et al.The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis[J].Proteomics, 2010, 10 (2) :266-276.
    [27]Ren F, Wu H, Lei Y, et al.Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma[J].Mol Cancer, 2010, 9 (1) :81.
    [28]Wu L, Peng CW, Hou JX, et al.Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation[J].J Exp Clin Cancer Res, 2010, 29 (1) :17.
    [29]Bin-sheng F, Wei L, Jian-wen Z, et al.Serum proteomic analysis on metastasis-associated proteins of hepatocellular carcinoma[J].J South Med Univ, 2009, 29 (9) :1775-1779.
    [30]Shu H, Kang X, Guo K, et al.Diagnostic value of serum haptoglobin protein as hepatocellular carcinoma candidate marker complementary to alpha fetoprotein[J].Oncol Rep, 2010, 24 (5) :1271-1276.
    [31]Long J, Lang ZW, Wang HG, et al.Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinomas[J].Hepatobiliary Pancreat Dis Int, 2010, 9 (3) :296-305.
    [32]Yang F, Yin Y, Wang F, et al.An altered pattern of liver apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression[J].J Proteome Res, 2010, 9 (1) :134-143.
    [33]Huang Q, Wang L, Bai S, et al.Global proteome analysis of hepatitis B virus expressing human hepatoblastoma cell line HepG2[J].J Med Virol, 2009, 81 (9) :1539-1550.
    [34]Ma Y, Yu J, Chan HL, et al.Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus[J].Mol Cell Proteomics, 2009, 8 (11) :2582-2594.
    [35]Feng H, Wang M, Chen WN.iTRAQ-coupled 2D LC-MS/MS analysis of secreted proteome of HBV-replicating HepG2 cells:potential in biomarkers for prognosis of HCC[J].Curr Microbiol, 2010, 61 (4) :280-284.
    [36]Feng H, Li X, Niu D, et al.Protein profile in HBx transfected cells:a comparative iTRAQ-coupled 2D LC-MS/MS analysis[J].J Proteomics, 2010, 73 (8) :1421-1432.
    [37]Niu D, Sui J, Zhang J, et al.iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile associated with HBV-modulated DNA methylation[J].Proteomics, 2009, 9 (15) :3856-3868.
    [38]Zhang J, Niu D, Sui J, et al.Protein profile in hepatitis B virus replicating rat primary hepatocytes and HepG2 cells by iTRAQ-coupled 2-D LC-MS/MS analysis:Insights on liver angiogenesis[J].Proteomics, 2009, 9 (10) :2836-2845.
    [39]Wang X, Zhou Y, Sun L, et al.Complex Formation between Heat Shock Protein 72 and Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues[J].J Proteome Res, 2008, 7 (12) :5133-5137.
    [40]Kim SY, Lee PY, Shin HJ, et al.Proteomic analysis of liver tissue from HBx-transgenic mice at early stages of hepatocarcinogenesis[J].Proteomics, 2009, 9 (22) :5056-5066.
  • Relative Articles

    [1]Xue Miao, Mao XiaoRong, Chen Hong. Change in T helper 17 cell/regulatory T cell imbalance in rats with immunological liver injury[J]. Journal of Clinical Hepatology, 2020, 36(1): 149-152. doi: 10.3969/j.issn.1001-5256.2020.01.033
    [2]Wang HaiYan, Zhu Li, Wang YinLing, Zhu YuePing, Zhu XiaoYan, Chai XiaoZhe, Qian Feng, Li Ming, Zhu ChuanWu. Impact of pegylated interferon versus conventional interferon on the change in peripheral CD4+CD25highT cells in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2018, 34(1): 53-57. doi: 10.3969/j.issn.1001-5256.2018.01.011
    [3]Chen Bin, Zhang Tao, Zhu WenFang, Peng Jie, Zhang QianQian, Li YunFang, Ding XiuLi. Effect of the warming and heat-clearing method on the percentage of regulatory T lymphocytes/T helper 17 cells in rats with acute-on-chronic liver failure[J]. Journal of Clinical Hepatology, 2018, 34(12): 2642-2647. doi: 10.3969/j.issn.1001-5256.2018.12.026
    [4]Li Yu, Tian Ying, Yang XiaoMei, Cao NingJia, Li Zhu, Zhang Hong, Zhang XianJiao. Effect of thymosin α1 on the function of CD4+CD25+CD127dim/- regulatory T cells in chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2018, 34(5): 1011-1014. doi: 10.3969/j.issn.1001-5256.2018.05.017
    [5]Gao WeiHua, Ge KuanXue, Xiang XiaoXing. Association of Th17 cells, regulatory T cells, and their imbalance with nonalcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2018, 34(6): 1347-1350. doi: 10.3969/j.issn.1001-5256.2018.06.046
    [6]Ge KuanXue, Gao WeiHua, Xiang XiaoXing. Association of regulatory T cells, T helper 17 cells, and change in their balance with autoimmune hepatitis[J]. Journal of Clinical Hepatology, 2018, 34(7): 1573-1576. doi: 10.3969/j.issn.1001-5256.2018.07.045
    [7]Guo FeiBo, Wu JunZhu, Ai LiMing, Song Ying. Clinical significance of Th17/Treg and associated cytokines in peripheral blood in chronic hepatitis C patients with liver cirrhosis[J]. Journal of Clinical Hepatology, 2017, 33(3): 479-484. doi: 10.3969/j.issn.1001-5256.2017.03.017
    [8]He JunNan, Zhao ShouSong. Research advances in association between regulatory T cells and hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2016, 32(2): 361-365. doi: 10.3969/j.issn.1001-5256.2016.02.036
    [9]Guo FeiBo. Change in peripheral blood CD4~+ regulatory T cells and its association with antiviral effect in patients with chronic hepatitis C[J]. Journal of Clinical Hepatology, 2016, 32(12): 2317-2321. doi: 10.3969/j.issn.1001-5256.2016.12.017
    [10]Zhou Yan, Jing Xiang, Zhu ZhengYan. Roles of regulatory T cells and T-helper cells in hepatitis B virus-related liver diseases[J]. Journal of Clinical Hepatology, 2016, 32(10): 1994-1997. doi: 10.3969/j.issn.1001-5256.2016.10.040
    [11]Cheng Ping, Xue BoYu. Research progress in Treg/Th17 imbalance in persistent HBV infection[J]. Journal of Clinical Hepatology, 2015, 31(4): 603-606. doi: 10.3969/j.issn.1001-5256.2015.04.031
    [12]Huang JinFa, Xu Tao, Pan XingNan, Lai XiaoHuan, Zheng LianQiu, Huang ZhiJie. Measurement of peripheral blood Treg,Tr1,and Th17 cells in patients with chronic hepatitis B and its clinical significance[J]. Journal of Clinical Hepatology, 2015, 31(4): 551-555. doi: 10.3969/j.issn.1001-5256.2015.04.018
    [13]Cai ShaoPing, Zhang WenJin, He WeiPing, Fan ZhenPing, Ji YingJie. Efficacy and safety of interferon plus ribavirin in elderly patients with chronic hepatitis C: report of 4 cases[J]. Journal of Clinical Hepatology, 2014, 30(1): 69-71. doi: 10.3969/j.issn.1001-5256.2014.01.019
    [14]Chen HuiJuan, Zhao ShouSong. Recent insights into the roles of regulatory T cells in viral hepatitis[J]. Journal of Clinical Hepatology, 2012, 28(11): 868-871.
    [15]Wu YinYa, Tan ShanZhong, Zhao Lei, Sun WeiWei, Shen JianJun, Liang ZhongFeng. The changes and value of the proportion of CD4+CD25+ regulatory T cells in HBeAg (+) and HBeAg (-) ASC in peripheral blood[J]. Journal of Clinical Hepatology, 2012, 28(3): 209-211.
    [16]Huang ZhongFa, Zhu Qing, Fu QiMei, Bu QuanHui, Shi BinBin. The effect of Interferon treatment on cellular immuneresponses in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2009, 25(5): 326-328.
    [17]Zhu ChuanWu, Qian Feng, Wang HaiYan, Li Ming, Chang JianGuo, Zhang XueHua, Xu KeLing, Wang YongPing, Gao ShengLan, Tong FuYi. Effect of Interferon-α therapy on production of IL-12 secreted by peripheral blood dendritic cells in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2004, 20(2): 77-79.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3810) PDF downloads(979) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return