Role of CD4+CD25+ T regulatory cells in HBeAg seroconversion during interferon antiviral

Jiang ShuLian; Tan ShanZhong; Wen Jian

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Jul. 2012

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Article Navigation > Journal of Clinical Hepatology > 2012 > 28(7): 528-530

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Role of CD4+CD25+ T regulatory cells in HBeAg seroconversion during interferon antiviral

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Published Date: 2012-07-20

Abstract

Abstract

Objective To investigate the role of CD4+CD25+ T regulatory cells in hepatitis B e antigen (HBeAg) serological conversion during anti-hepatitis B virus (HBV) treatment using interferon.Methods Fifty-six HBeAg-positive chronic HBV patients were administered interferon-alpha 2b (5 000 000 U) intramuscularly every other day for one year.CD4+CD25+ T regulatory cells were detected by flow cytometry before treatment and 48 weeks after treatment initiation.Results The level of CD4+CD25+ T regulatory cells was significantly reduced by interferon-alpha 2b treatment in patients with HBeAg conversion (before: 11.99%±3.25% vs 48 weeks: 9.12%±2.45%;P<0.05) .However, no decrease in the level of T regulatory cells was observed in the group without HBeAg conversion.Conclusion In chronic HBV, interferon treatment decreases the level of CD4+CD25+ T regulatory cells in patients with HBeAg seroconversion, but not in patients without HBeAg seroconversion.
- hepatitis B e antigens,
- interferon,
- T-lymphocytes

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沈阳化工大学材料科学与工程学院沈阳 110142

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Role of CD4+CD25+ T regulatory cells in HBeAg seroconversion during interferon antiviral

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