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Advances in the application of magnetic resonance imaging in hepatic fat quantification in patients with nonalcoholic fatty liver disease
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摘要:
肝脂肪含量是非酒精性脂肪性肝病的早期诊断、疾病分级和疗效评估的重要指标。多种磁共振技术已被用来评估肝脂肪含量,其中磁共振波谱分析和化学位移编码成像获得的质子密度脂肪分数已能精确定量肝脏脂肪,被认为是脂肪肝诊断的影像学金标准并被应用于临床研究中。回顾定量检测肝脂肪含量的磁共振技术的研究进展,以期为临床应用和实验研究提供参考。
Abstract:Hepatic fat content is an important index for the early diagnosis,disease grading,and outcome evaluation of nonalcoholic fatty liver disease( NAFLD). Various magnetic resonance imaging( MRI) methods have been used to determine hepatic fat content in NAFLD,among which proton density fat fraction obtained by magnetic resonance spectroscopy and chemical-shift-encoded MRI can achieve precise quantification of hepatic fat and therefore,it is considered the imaging gold standard for the diagnosis of fatty liver disease and has been applied in clinical research. This article reviews the research advances in the MRI techniques for quantification of hepatic fat content,in order to provide a reference for clinical application and experiment.
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