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CN 22-1108/R
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2015 No. 3

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Editorial
Quantitative assessment of liver fibrosis: invasive or non-invasive?
Liang XieEr, Wang Yan, Hou JinLin
2015, 31(3): 317-321. DOI: 10.3969/j.issn.1001-5256.2015.03.001
Abstract(516) PDF (360KB)(222)
Abstract:
Precise and quantitative assessment of the severity of liver fibrosis is of great value for confirming diagnosis,making treatment decision,monitoring treatment outcome,and determining prognosis. This paper analyzes the development and application of invasive and non- invasive quantitative assessment...
Therapeutic guidelines
Guidelines for the management of chronic pancreatitis(2014)
Group of Pancreas Surgery, Chinese Society of Surgery, Chinese Medical Association
2015, 31(3): 322-326. DOI: 10.3969/j.issn.1001-5256.2015.03.002
Abstract(340) PDF (2020KB)(966)
Abstract:
Guidelines for integrated traditional Chinese and Western medicine diagnosis and treatment of severe acute pancreatitis (2014, Tianjin)
General Surgery Committee, China Society of Integrated Traditional Chinese and Western Medicine
2015, 31(3): 327-331. DOI: 10.3969/j.issn.1001-5256.2015.03.003
Abstract(357) PDF (241KB)(1288)
Abstract:
Discussions by experts
Clinical application of noninvasive diagnosis of liver fibrosis
Zhu ChuanLong, Wang Kun, Gao RenDao
2015, 31(3): 332-336. DOI: 10.3969/j.issn.1001-5256.2015.03.004
Abstract(3067) PDF (1477KB)(763)
Abstract:
Hepatic fibrosis is the common outcome of chronic liver diseases of various causes. At present,liver biopsy is the “gold standard”for the diagnosis of liver fibrosis,but it has limitations and is invasive,which leads to the development of noninvasive assessment of liver fibrosis. The article mainly ...
Mechanisms and treatment of cholestasis- induced liver fibrosis
Zhang QiDi, Lu LunGen
2015, 31(3): 337-341. DOI: 10.3969/j.issn.1001-5256.2015.03.005
Abstract(3088) PDF (1459KB)(708)
Abstract:
Any pathological state that causes disturbance in bile flow is called cholestasis. Liver fibrosis is a repair response to liver injury.Both cholestasis and liver fibrosis are pathological states in liver diseases. This paper briefly introduces cholestasis and liver fibrosis,and illustrates the mecha...
Study on pathogenesis of schistosomal liver fibrosis
Zhao Lei, Yang DongLiang
2015, 31(3): 342-344. DOI: 10.3969/j.issn.1001-5256.2015.03.006
Abstract(3027) PDF (1438KB)(583)
Abstract:
The important pathological feature induced by schistosomiasis is liver fibrosis. Schistosome eggs release soluble egg antigen to form egg granuloma,which stimulates host inflammation,induces extracellular matrix deposition,and finally causes liver fibrosis. This process is tightly associated with he...
Anti-viral therapy for chronic hepatitis B and cirrhosis: monotherapy or combination?
Shi YiWen, Wang Lin, You Hong
2015, 31(3): 345-348. DOI: 10.3969/j.issn.1001-5256.2015.03.007
Abstract(313) PDF (207KB)(107)
Abstract:
At present,the response rate of anti- viral therapy for chronic hepatitis B still needs to be increased. Therefore,combination therapy including nucleosides combined with nucleotides,as well as interferon combined with nucleosides and nucleotides,is being explored by many researchers. According to r...
Early diagnosis and empiric therapy for cirrhosis associated with infection
Nan YueMin, Niu XueMin
2015, 31(3): 349-353. DOI: 10.3969/j.issn.1001-5256.2015.03.008
Abstract(3127) PDF (1457KB)(695)
Abstract:
Infection is a frequent complication of cirrhosis,which often occurs in the lungs,chest,abdomen,biliary tract,urinary tract,soft tissue,and skin,and occasionally causes spontaneous bacteremia in patients. This paper reviews the risk factors and common types of infection in cirrhosis associated with ...
Therapeutic strategy for gastroesophageal variceal bleeding of portal hypertension
Tian XiangGuo, Zhang ChunQing
2015, 31(3): 354-356. DOI: 10.3969/j.issn.1001-5256.2015.03.009
Abstract(3076) PDF (1437KB)(685)
Abstract:
Gastroesophageal variceal bleeding is a severe complication of portal hypertension. The prevention of gastroesophageal variceal bleeding and rebleeding remains an important goal in treating patients with liver cirrhosis. This article briefly describes the four stages of the prevention and treatment ...
Original articles_Liver fibrosis and liver cirrhosis
Diagnostic value of serum apolipoprotein B/A1 ratio for hepatic fibrosis(F≥2) in chronic hepatitis C patients
Lei ChengDuo, Li JunFeng, Zheng SuJun, Ren Yan, Zhao Jing, Zhang JingYun, Duan ZhongPing
2015, 31(3): 357-360. DOI: 10.3969/j.issn.1001-5256.2015.03.010
Abstract(351) PDF (292KB)(80)
Abstract:
Objective To investigate the relationship between serum apolipoprotein B / A1( APOB / APOA1) ratio and chronic hepatitis C( CHC)- related hepatic fibrosis,and to assess the ability of serum APOB/APOA1 ratio to identify significant hepatic fibrosis( ≥F2).Methods A total of 120 interferon treatment- n...
Relationship between serum markers and severity of liver fibrosis in patients with chronic hepatitis D
Zhou Ying, Xiong HongPin, Chen Keng, Ping Qu, Liao BaoLin
2015, 31(3): 361-364. DOI: 10.3969/j.issn.1001-5256.2015.03.011
Abstract(2900) PDF (1454KB)(596)
Abstract:
Objective To explore the relationship between levels of alanine aminotransferase( ALT),hepatitis B virus( HBV) DNA,and serum markers of fibrosis including hyaluronic acid( HA),laminin( LN),type Ⅲ procollagen peptide( PⅢP),and type Ⅳ collagen( CⅣ) and the severity of liver fibrosis in patients with c...
Clinical value of nucleotide analogues for treatment of hepatitis B-related decompensated cirrhosis
Zhang XueHua, Li ZhongPing
2015, 31(3): 365-369. DOI: 10.3969/j.issn.1001-5256.2015.03.012
Abstract(230) PDF (235KB)(145)
Abstract:
Objective To investigate the clinical value of nucleotide analogues for the treatment of hepatitis B- related decompensated cirrhosis. Methods A total of 97 inpatients with hepatitis B- induced decompensated cirrhosis were selected from the Department of Hepatology,Nanhua Hospital,Shanghai,China,fro...
Diagnosis and treatment of primary bleeding from esophageal varices in cirrhotic patients from Yangzhou,China: an analysis of 80 cases
Zhou HongHua, Xiang XiaoXing, Zhang MiaoMiao
2015, 31(3): 370-373. DOI: 10.3969/j.issn.1001-5256.2015.03.013
Abstract(2955) PDF (1452KB)(570)
Abstract:
Objective To investigate the diagnosis and treatment of primary bleeding from esophageal varices( EVB) in cirrhotic patients from Yangzhou,China. Methods A retrospective analysis was performed on 80 cirrhotic patients with primary BEV who were treated at the Department of Gastroenterology,Northern J...
Correlation study of spleen stiffness measured by Fibro Touch with esophageal and gastric varices in patients with liver cirrhosis
Wei YuTong, Jia ShengNan, Liu MiaoMiao, Xiao HeJun, Pan LiuLan
2015, 31(3): 374-377. DOI: 10.3969/j.issn.1001-5256.2015.03.014
Abstract(3429) PDF (1485KB)(687)
Abstract:
Objective To explore the correlation of spleen stiffness measured by Fibro Scan with esophageal and gastric varices in patients with liver cirrhosis. Methods Spleen and liver stiffness was measured by Fibro Scan in 72 patients with liver cirrhosis who received gastroscopy in our hospital from Decemb...
Preliminary research on quantitative evaluation of carotid artery elasticity in patients with cirrhosis using ultrafast pulse wave velocity technique
Zhang Hong, Zhou Qi, Jiang Jue
2015, 31(3): 378-380. DOI: 10.3969/j.issn.1001-5256.2015.03.015
Abstract(2942) PDF (1513KB)(530)
Abstract:
Objective To explore the value of ultrafast pulse wave velocity( UFPWV) technique in the quantitative evaluation of carotid artery elasticity in patients with cirrhosis. Methods Forty- three patients diagnosed clinically with cirrhosis in our hospital from September2013 to June 2014 were enrolled as...
Relationship between portal vein pressure and Fibro Scan score in cirrhotic patients with concomitant portal hypertension
Cheng XiaoFei, Liang XiongBo, Xiong XiaoQing, Tang YongLi, Chen Ping
2015, 31(3): 381-383. DOI: 10.3969/j.issn.1001-5256.2015.03.016
Abstract(2432) PDF (1440KB)(486)
Abstract:
Objective To analyze the relationship between portal vein pressure and Fibro Scan score in patients with liver cirrhosis using color Doppler ultrasonography and transient elastography( Fibro Scan). Methods Totally 235 patients with liver cirrhosis were selected from the Second People's Hospital of Z...
Curative effect of peritoneal lavage in treatment of cirrhotic patients with spontaneous bacterial peritonitis
Yang ZhengMao, Shi WenJuan, Zhou Jian, Wang ZhaoXun
2015, 31(3): 384-386. DOI: 10.3969/j.issn.1001-5256.2015.03.017
Abstract(2384) PDF (1436KB)(500)
Abstract:
Objective To investigate the value of peritoneal lavage in the treatment of cirrhotic patients with spontaneous bacterial peritonitis( SBP). Methods Eighty- six cirrhotic patients with SBP who were admitted to the Department of Infection in our hospital from February 2010 to February 2013 were selec...
Value of five-stage prognostic system in predicting short-term outcome of patients with liver cirrhosis
Tian Yan, Hu NaiZhong
2015, 31(3): 387-391. DOI: 10.3969/j.issn.1001-5256.2015.03.018
Abstract(311) PDF (447KB)(66)
Abstract:
Objective To evaluate the clinical value of five- stage prognostic system in predicting the short- term outcome of patients with liver cirrhosis,and to compare it with the Child- Turcotte- Pugh( CTP) and Model of End- Stage Liver Disease( MELD) scores. Methods Two hundred and one hospitalized patien...
Relationship between intestinal dysbacteriosis and Child-Pugh classification in patients with cirrhosis
Huang XiaoYu, Li GangPing, Kou JiGuang, Li Lei, Xia XiuMei, Yang Ling, Hou XiaoHua
2015, 31(3): 392-395. DOI: 10.3969/j.issn.1001-5256.2015.03.019
Abstract(2245) PDF (1454KB)(519)
Abstract:
Objective To evaluate the distribution of intestinal flora in patients with cirrhosis compared with healthy people and investigate the relationship between the distribution of intestinal flora and Child- Pugh classification of liver function,and to analyze the effect of probiotic treatment on the im...
Analysis of risk factors for rebleeding after splenectomy and pericardial devascularization in treatment of portal hypertension due to liver cirrhosis
Zhang Lei, Yue Ping, Song XiaoJing, Yue Wei, Li Xun, Yuan Hong, Deng WanRong
2015, 31(3): 396-399. DOI: 10.3969/j.issn.1001-5256.2015.03.020
Abstract(2473) PDF (1450KB)(556)
Abstract:
Objective To investigate the possible risk factors for rebleeding after splenectomy and pericardial devascularization in the treatment of portal hypertension due to liver cirrhosis,and to provide a certain basis for reducing the incidence of digestive tract re- hemorrhage for these patients. Methods...
Cause analysis of early portal vein thrombosis after esophagogastric devascularization and splenectomy in cirrhotic patients with portal hypertension
Wu XiaoFeng, Fu Zhi, Liu ZhaoBo, Meng Jian, Li ChuanYun, Lin DongDong
2015, 31(3): 400-403. DOI: 10.3969/j.issn.1001-5256.2015.03.021
Abstract(2163) PDF (1445KB)(587)
Abstract:
Objective To identify the causative factors for early portal vein thrombosis( EPVT) after esophagogastric devascularization and splenectomy( EGDS) in cirrhotic patients with portal hypertension. Methods A 3- month follow- up of a retrospective study was performed on 83 patients who received EGDS at ...
Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis
Lu XiaoMin, Wang ZhenNing, Yang Jun
2015, 31(3): 404-406. DOI: 10.3969/j.issn.1001-5256.2015.03.022
Abstract(1891) PDF (1438KB)(454)
Abstract:
Objective To investigate the levels of molecular markers of prethrombotic state in liver cirrhosis( LC) patients with portal vein thrombosis( PVT) and their significance. Methods Seventy- two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patien...
Analysis of pathogenic features of liver cirrhosis with spontaneous bacterial peritonitis
Zhang JuLing, Geng Wei, Cui EnBo, Yuan Yuan, Zhang ChengLong, Chen SuMing, Jia TianYe, Wang Huan, Bao ChunMei, Qu Fen
2015, 31(3): 407-412. DOI: 10.3969/j.issn.1001-5256.2015.03.023
Abstract(2473) PDF (1481KB)(530)
Abstract:
Objective To analyze the pathogenic and drug resistance features,as well as laboratory indices,of spontaneous bacterial peritonitis( SBP) and to provide a basis for the early warning,rapid diagnosis,and timely treatment of the disease. Methods The clinical data and laboratory indices of 1340 patient...
Clock drawing test in cognitive assessment for patients with hepatitis B cirrhosis
Sun YuMei, Zhou YingXia, Xing HuiChun, Lin KeKe
2015, 31(3): 413-417. DOI: 10.3969/j.issn.1001-5256.2015.03.024
Abstract(2057) PDF (1466KB)(480)
Abstract:
Objective To explore the significance and potential influencing factors for the clock drawing test( CDT) in cognitive assessment for patients with hepatitis B cirrhosis. Methods Ninety- five Child- Turcotte- Pugh class A patients with hepatitis B cirrhosis,who were admitted to our hospital from June...
Dynamic change of hepcidin in liver fibrosis induced by CCl4 among mice
Pang GuoJin, Chen ShuangJun, Zhao WeiHua, Liu TianHui, Wang Ping, You Hong, Cong Min
2015, 31(3): 418-423. DOI: 10.3969/j.issn.1001-5256.2015.03.025
Abstract(458) PDF (1726KB)(213)
Abstract:
Objective To investigate the dynamic change of hepcidin in liver fibrosis induced by CCl4 among mice. Methods C57 BL /6mice were given CCl4 by intragastric administration to establish a liver fibrosis model. The degree of liver injury and fibrosis was evaluated by HE and Masson staining. Prussian bl...
Therapeutic effect of estradiol-pretreated human bone marrow mesenchymal stem cells on liver cirrhosis in mice
Yan XiaoMing, Zhang LiTing, Luo JingYi, Xiao Ping
2015, 31(3): 424-430. DOI: 10.3969/j.issn.1001-5256.2015.03.026
Abstract(2301) PDF (3081KB)(451)
Abstract:
Objective To explore the effect of estradiol on human bone marrow mesenchymal stem cells( BMSCs) and the therapeutic effect of estradiol- pretreated BMSCs on liver cirrhosis in mice. Methods Third- passage BMSCs were divided into control( untreated with estradiol) and experimental groups( treated wi...
Brief reports
Clinical effects of hand-assisted laparoscopic vs open splenectomy combined with pericardial devascularization  the treatment of portal hypertension in liver cirrhosis
Bao HanKang, Wei XiuLi
2015, 31(3): 431-433. DOI: 10.3969/j.issn.1001-5256.2015.03.027
Abstract(309) PDF (262KB)(58)
Abstract:
Case reports
One case of hepatitis B cirrhosis complicated by rhabdomyolysis
Zhang DaLi, Zhang Min, Su HaiBin
2015, 31(3): 434-435. DOI: 10.3969/j.issn.1001-5256.2015.03.028
Abstract(2963) PDF (1428KB)(569)
Abstract:
One case of spontaneous recanalization of acute portal vein thrombosis in patients with cirrhosis
Jiang HongLi, Zhang Rui, Hu YuLin, Xin GuiJie
2015, 31(3): 436-437. DOI: 10.3969/j.issn.1001-5256.2015.03.029
Abstract(2926) PDF (1455KB)(543)
Abstract:
Alcoholic cirrhosis with localized hepatic fatty infiltration misdiagnosed as liver cancer: a report of one case and literature review
Tang ShanHong, Yang DeHui, Ceng WeiZheng, Wu XiaoLing, Wang Zhao, Zhou XiaoLei, Li HongYong, Chen HongChao, Fan QuanShui, Jiang MingDe
2015, 31(3): 438-440. DOI: 10.3969/j.issn.1001-5256.2015.03.030
Abstract(2895) PDF (1557KB)(588)
Abstract:
One case of poikiloderma vasculare atrophicans with cirrhosis
Wang HongJie, Zhou JingJing, Sun Ying, Wen XiaoYu, Jin QingLong
2015, 31(3): 441-442. DOI: 10.3969/j.issn.1001-5256.2015.03.031
Abstract(2955) PDF (1504KB)(556)
Abstract:
Treatment of hemoperitoneum following transjugular intrahepatic portosystemic shunt: a report of 4 cases and literature review
Hu WeiLin, Luo XiaoPing, Ling Ning, Shi XiaoFeng, Huang Ying, Yang YiXuan, Ceng WeiQun, He Hua, Zhang DaZhi
2015, 31(3): 443-446. DOI: 10.3969/j.issn.1001-5256.2015.03.032
Abstract(2783) PDF (1514KB)(507)
Abstract:
Reviews
Roles of Nrf2 and autophagy in liver fibrosis
Wang WeiHao, Xu WeiHua
2015, 31(3): 447-451. DOI: 10.3969/j.issn.1001-5256.2015.03.033
Abstract(2654) PDF (1473KB)(553)
Abstract:
Liver fibrosis is an essential stage in the progression of chronic liver disease to liver cirrhosis,and its incidence is high in the world. The mechanism of liver fibrosis that involves many cytokines and signaling pathways is complicated and is understood by people more and more clearly. This revie...
Signal transduction involved in activation of hepatic stellate cells
Ren ChangZhen, Hao LiSen
2015, 31(3): 452-456. DOI: 10.3969/j.issn.1001-5256.2015.03.034
Abstract(2955) PDF (1701KB)(840)
Abstract:
Hepatic stellate cells( HSCs) are the source of fibre in the liver which can produce a large number of extracellular matrix via proliferation and activation,and this is the central link of hepatic fibrosis. Following further research on hepatic fibrosis,signal transduction involved in the activation...
Role of Hedgehog signaling pathway in progression of non-alcoholic fatty liver fibrosis
An BaiQuan, Jiang Man, Xin YongNing, Jiang XiangJun, Liu ZhenSheng, Xuan ShiYing
2015, 31(3): 457-459. DOI: 10.3969/j.issn.1001-5256.2015.03.035
Abstract(2979) PDF (1675KB)(527)
Abstract:
Obesity and related metabolic syndromes are prevalent on the global scale. Thus far,non- alcoholic fatty liver( NAFL) disease has caused wide attention from domestic and overseas scholars. NAFL cirrhosis is considered to be the central part and inevitable stage of liver cirrhosis developed from simp...
Research progress in antiviral therapy for decompensated hepatitis B cirrhosis
Tu YanYun, Chen HaiYan, Liu XuDong
2015, 31(3): 460-464. DOI: 10.3969/j.issn.1001-5256.2015.03.036
Abstract(3284) PDF (1478KB)(630)
Abstract:
Decompensated hepatitis B cirrhosis is one of the final outcomes of chronic hepatitis B and liver fibrosis. Extensive studies have demonstrated that antiviral therapy can slow disease progression,improve clinical outcomes,reduce complications,slow decompensated cirrhosis progression,and improve surv...
Progress in treatment of liver cirrhosis
Zhang JingWen, Shi YongQuan, Han Ying
2015, 31(3): 465-468. DOI: 10.3969/j.issn.1001-5256.2015.03.037
Abstract(3685) PDF (1453KB)(789)
Abstract:
Liver cirrhosis is a late- stage hepatic fibrosis,which results from various risk factors such as viruses,alcohol,fat,drugs and immunity,and genetic metabolism,leading to chronic liver damage. This paper reviews the etiological treatment and therapy for complications. It is pointed out that liver tr...
Research advances in role of carvedilol in management of cirrhotic portal hypertension: a review of clinical trials
Yang ChunJiao, Qi XingShun, Guo XiaoZhong
2015, 31(3): 469-471. DOI: 10.3969/j.issn.1001-5256.2015.03.038
Abstract(3411) PDF (1435KB)(592)
Abstract:
The primary aim of preventing variceal bleeding in liver cirrhosis is to reduce portosystemic pressure gradient. Carvedilol is a non- selective beta blocker with selective inhibition of α- 1 receptor and blockage of calcium channel. This paper reviews the role of carvedilol in reducing hepatic venou...
Diagnosis and treatment procedure for intractable liver ascites
Fan ZhiDong, You JinLi
2015, 31(3): 472-474. DOI: 10.3969/j.issn.1001-5256.2015.03.039
Abstract(2518) PDF (1438KB)(615)
Abstract:
Ascites is a common complication of liver cirrhosis. Liver ascites may occur repeatedly,which increases the therapeutic difficulty. This paper reviews the definition of intractable liver ascites,general treatment measures,and current treatment of common complications such as spontaneous bacterial pe...
Progress in application of branched- chain amino acids in patients with liver cirrhosis
Lu: Zheng, Meng QingHua
2015, 31(3): 475-477. DOI: 10.3969/j.issn.1001-5256.2015.03.040
Abstract(2871) PDF (1442KB)(583)
Abstract:
The metabolism of amino acids mainly takes place in the liver,and patients with liver cirrhosis may develop metabolic disorders of proteins,carbohydrates,fats,and amino acids,which in turn causes dysfunction of multiple organs and systems,as well as complications like hepatic encephalopathy,esophage...
Role of vascular biology in portal hypertension
Ren XiaoLi, Shi YongQuan, Han Ying
2015, 31(3): 478-481. DOI: 10.3969/j.issn.1001-5256.2015.03.041
Abstract(1965) PDF (1457KB)(485)
Abstract:
The development of portal hypertension is associated with remarkable changes in the intra- and extra- hepatic vasculature. Thus far,in- depth research into vascular biology has furthered our understanding about the mechanism of dynamic vascular changes associated with portal hypertension. Advances i...
    

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