Primary biliary cirrhosis( PBC) is an autoimmune liver disease characterized by the destruction of small intrahepatic bile ducts.Incomprehensible and complicated autoreactive responses participate in the development and progression of PBC,which involve various immune cells and inflammatory mediators...

Autoimmune hepatitis( AIH) is a progressive,chronic hepatitis of unknown cause. It is characterized by interface hepatitis,hypergammaglobulinaemia,circulating autoantibodies,and a favorable response to immunosuppression. This article summarizes the epidemiological and clinical characteristics of AIH...

Primary biliary cirrhosis( PBC) is a chronic progressive cholestatic liver disease associated with immunity,with unknown etiology and pathogenesis. This article reviews the origin of its name,recent advances in research on PBC,and the prospect of treatment. Ursodeoxycholic acid is considered to be e...

Primary biliary cirrhosis( PBC) is an autoimmune cholestatic liver disease. In this review,the epidemiology of PBC,which varies in different countries and regions,is comprehensively introduced. Furthermore,the natural history of PBC before and after the wide application of ursodeoxycholic acid is an...

Sclerosing cholangitis can be divided into primary sclerosing cholangitis( PSC) and secondary sclerosing cholangitis according to the etiology and pathogenesis,and the pathogenesis of PSC may be associated with immunity. In recent years,a new type of sclerosing cholangitis has been found,which is ch...

Autoimmune liver disease overlap syndrome is a special type of autoimmune disease,and consensus has not been reached regarding the etiology and diagnosis and treatment. This paper reviews many aspects of overlap syndrome,such as etiology,pathogenesis,diagnosis and treatment,and its development proce...

Objective To evaluate the significance of combined analysis of different autoantibodies in the diagnosis of primary biliary cirrhosis( PBC). Methods Two- hundred and forty- five patients with liver diseases were randomly selected. According to the disease type,patients were divided into PBC group( n...

Objective To evaluate the clinical efficacy of Biejiaruangan compound tablets in the treatment of primary biliary cirrhosis( PBC). Methods In a randomized,double- blind,placebo- controlled study,56 patients with PBC were collected and equally divided into treatment group and control group. The treat...

Objective To investigate the correlation between clinical data and pathological stage in patients with primary biliary cirrhosis( PBC) and to provide guidance for clinical diagnosis and treatment. Methods The clinical data of 54 PBC patients were collected for analyzing the correlation between the c...

Objective To investigate the incidence and risk factors for endoscopic retrograde cholangiopancreatography( ERCP)- related adverse events in patients with primary sclerosing cholangitis( PSC). Methods This study included 72 patients who were diagnosed with PSC by magnetic resonance cholangiopancreat...

Objective To investigate the clinical efficacy of pegylated interferon α- 2a( PEG- IFNα- 2a) in the treatment of children with HBe Ag- positive chronic hepatitis B( CHB). Methods A total of 31 children with CHB aged from 2- 16 years were randomly enrolled in this study and divided into two groups ba...

Objective To screen hepatitis B virus( HBV)- infected patients with normal alanine aminotransferase( ALT) using Fibro Scan( FS). Methods Liver biopsy was done for all the 125 patients who were admitted to our hospitals from November 2012 to November 2013,and FS was performed for the liver stiffness ...

Objective To study the efficacy of thymosin α1 in the treatment of chronic hepatitis B virus( HBV) infection with low viral load. Method Seventy- six patients with low- viral load chronic HBV infection admitted to our hospital from June 2011 to June 2013 were randomly assigned to treatment group,and...

Objective To measure the expression of T- cell immunoglobulin- and mucin domain- 3- containing molecule 3( TIM- 3)on CD8+T cells in peripheral blood mononuclear cells( PBMCs) among patients with chronic hepatitis B( CHB) and to investigate the effect of common gamma- chain cytokines on the expressio...

Objective To investigate the early diagnostic value of single or combined measurement of serum procalcitonin( PCT),peripheral white blood cells( WBC),and ratio of WBC to platelets( PLT)( WBC / PLT) for spontaneous bacterial peritonitis( SBP) in patients with liver cirrhosis. Methods The clinical dat...

Objective The administration of octreotide,as well as terlipressin,is a routine treatment for acute variceal bleeding in cirrhotic patients. This study aimed to evaluate the effects of octreotide,terlipressin,and their combination on hepatic venous pressure gradient( HVPG) in cirrhotic patients. Met...

Objective To compare serum biochemical parameters,liver pathology,and fibronectin( FN) expression in Wister rats with hepatic fibrosis induced by bile duct ligation( BDL) and carbon tetrachloride( CCl4). Methods Ninety healthy male Wister rats were assigned to CCl4model( n = 44),CCl4control( n = 6),...

Objective To assess the efficacy of intrahepatic arterial infusion of Endostar( rh- endostatin,YH- 16) combined with transcatheter arterial chemoembolization( TACE) for the treatment of advanced hepatocellular carcinoma( a HCC). Methods The study enrolled 76 a HCC patients who were admitted to and t...

Objective To investigate the relevant risk factors for early recurrence after microwave ablation for primary hepatocellular carcinoma( HCC),and to provide a reference for predicting and preventing tumor recurrence. Methods A retrospective analysis was conducted on the clinical data of 80 patients wh...

Objective To explore the clinical value of three serum tumor markers,Golgi protein 73( GP73),alpha- fetoprotein( AFP),and AFP- L3,in the diagnosis of liver cancer and recurrence monitoring after radio frequency ablation. Methods A total of 174 patients who visited our hospital from July 2012 to Octo...

Objective To investigate the curative effect and prognostic impact of radical resection assisted by transcatheter arterial chemoembolization( TACE) in the treatment of intrahepatic cholangiocarcinoma( ICC). Methods The clinical data of 80 patients with ICC who were admitted to the Department of Hepa...

Objective To evaluate the relationship between estrogen receptor- α- 29( ERα- 29) gene polymorphisms and the development of HBV- related hepatocellular carcinoma( HCC) in Gansu Province,China,and to investigate the pathogenesis of HCC at the gene level. Methods Gene polymorphisms of ERα- 29 were ana...

Objective To investigate the effect of NOTCH4 expression on vasculogenic mimicry( VM) formation in hepatocellular carcinoma( HCC). Methods Tumor tissues were collected from 85 patients diagnosed with HCC. The relationship between NOTCH4 expression and VM was examined using immunohistochemical staini...

Objective To preliminarily investigate the relationship of Peg10 with focal adhesion kinase( FAK)- mediated cell adhesion-mediated drug resistance( CAM- DR) in hepatocellular carcinoma( HCC),and to explore the underlying molecular mechanism. Methods The effects of 5- fluorouracil( 5- Fu) and adriamy...

Objective To evaluate the value of thromboelastography( TEG) in guiding the proper use of blood components in patients after liver transplantation. Methods The blood samples from 35 patients after liver transplantation who visited our hospital from November 2013 to April 2014 were collected,in which...

Objective To assess the relationship between alcoholic fatty liver disease( AFLD) and carotid intima- media thickness( CIMT) and the influencing factors for CIMT. Methods A cross- sectional study was conducted in 147 males who were inpatients or had physical examination at the Taishan Hospital in Sh...

Objective To investigate the effects of niacin on the lipid metabolism in rat model of non- alcoholic fatty liver disease( NAFLD). Methods Forty Sprague- Dawley rats were randomly divided into control group,model group,intervention group 1( 0. 5%niacin),and intervention group 2( 1% niacin). Rats wer...

Liver steatosis is a frequent histological feature in patients with chronic hepatitis C( CHC),and it is associated with the progression of CHC and antiviral efficacy. This paper reviews recent research advances in the viral and host factors involved in the pathogenesis of steatosis among CHC patient...

Since the liver is the major iron storage organ in human body,iron metabolism disorder is closely related to chronic hepatitis. So far,the mechanisms underlying iron overload in chronic hepatitis C( CHC) have not been fully elucidated. Highly complex regulation of hepcidin relies on a number of vari...

Early diagnosis of liver fibrosis and dynamic monitoring of relevant changes have great implications for the treatment and prognosis improvement of chronic liver diseases. So far,liver biopsy remains the“golden standard”for the diagnosis and staging of liver fibrosis. However,due to its inherent lim...

Hedgehog( Hh) signaling pathway is present in many animals and plays an important role in regulating embryonic development and differentiation. Aberrant activation of Hh signaling contributes to the pathogenesis of many malignancies. Recent studies have shown that dysregulated Hh signaling pathway p...

Adult hepatoblastoma is extremely rare in clinical practice,and its pathogenesis is unknown. At present,there is a lack of understanding of this disease,and therefore clinical misdiagnosis is common. This review introduces the pathogenesis,clinical manifestations,and radiological and pathological ch...

Budd- Chiari syndrome( BCS) is characterized by the hepatic outflow obstruction from the small hepatic vein to the superior hepatic inferior vena cava. Portal vein thrombosis( PVT) refers to the development of thrombosis in the main portal vein,with or without thrombosis in the superior mesenteric o...

Silymarin is a traditional hepatoprotective herb for the adjuvant therapy of liver diseases,which shows marked pharmacological activities such as antioxidant and anti- inflammatory properties. This paper introduces the action mechanism of silymarin in regulating liver function,ameliorating hepatic f...