2018 No. 1

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Editorial

Molecular basis of hepatic fibrosis and current status of its diagnosis and treatment

Li Yan, Lu LunGen

2018, 34(1): 12-15. DOI: 10.3969/j.issn.1001-5256.2018.01.001

Abstract(2192)

PDF (1559KB)(626) Cited By (26)

Abstract:
During the process of acute or chronic liver injury, hepatic stellate cells interact with various types of cells such as hepatic parenchymal cells, Kupffer cells, and liver sinusoidal endothelial cells to mediate extracellular matrix deposition and sinusoid capillarization and thus initiate the proc...

Discussions by experts

The critical importance of diagnosing and treating liver fibrosis

Guo JinSheng

2018, 34(1): 16-19. DOI: 10.3969/j.issn.1001-5256.2018.01.002

Abstract(2698)

PDF (1551KB)(588) Cited By (13)

Abstract:
Liver fibrosis is the scar repairing reaction in response to chronic liver injury due to various etiologies. It has been considered as the early and reversible stage of liver cirrhosis. This article points out the distinction between liver fibrosis and cirrhosis, introduces the current staging syste...

Clinical application of quantitative assessment of liver fibrosis based on pathology and imaging technology

He ZhiYing, Wang BingQiong, You Hong

2018, 34(1): 20-23. DOI: 10.3969/j.issn.1001-5256.2018.01.003

Abstract(2560)

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Abstract:
Liver fibrosis/cirrhosis is a common pathological outcome of chronic hepatic diseases, and an accurate assessment of the degree of liver fibrosis has an important reference value in a definite diagnosis, treatment decision-making, clinical outcome monitoring, and prognostic evaluation. Two quantitat...

The natural history and clinical features of nonalcoholic fatty liver disease-related cirrhosis

Zhang XiaXia, Xu HongTuan, Xu YouQing

2018, 34(1): 24-26. DOI: 10.3969/j.issn.1001-5256.2018.01.004

Abstract(2602)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) is a type of metabolic liver injury closely associated with insulin resistance and genetic susceptibility and includes nonalcoholic simple fatty liver, nonalcoholic steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. It has become an important pu...

Association between liver vascular lesions and liver cirrhosis

Ning HuiBin, Shang Jia

2018, 34(1): 27-30. DOI: 10.3969/j.issn.1001-5256.2018.01.005

Abstract(2584)

PDF (1547KB)(541) Cited By (6)

Abstract:
Many factors can cause liver fibrosis and cirrhosis in clinical practice, and liver cirrhosis caused by liver vascular lesions often has insidious progression. Due to a lack of knowledge in clinicians and limited diagnostic and treatment techniques, patients often have poor prognosis. The liver vasc...

Road map of the diagnosis and treatment of intractable ascites based on guidelines for the diagnosis and treatment of cirrhotic ascites and related complications

Ding HuiGuo

2018, 34(1): 31-34. DOI: 10.3969/j.issn.1001-5256.2018.01.006

Abstract(735)

PDF (209KB)(639) Cited By (34)

Abstract:
Guidelines for the diagnosis and treatment of cirrhotic ascites and related complications put forward the new criteria for the diagnosis and treatment of intractable cirrhotic ascites, and spontaneous bacterial peritonitis is a common cause of intractable cirrhotic ascites. About 50% -89% of patient...

Academic contention

The medical laboratory issues about recommendation on uniform cutoff values of “normal” ALT in the ACG guidelines

Yu Qian, Pan BoShen

2018, 34(1): 35-38. DOI: 10.3969/j.issn.1001-5256.2018.01.007

Abstract(1981)

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Abstract:
In the recent American clinical guidelines dealing with laboratory tests for evaluation of liver disease, the American College of Gastroenterology ( ACG) recommends ALT upper reference limits of 33 U/L for males and 25 U/L for females respectively, and that individuals with ALT above these“normal”cu...

Therapeutic guidelines

An excerpt of recommendations on the use of magnetic resonance imaging in PSC - A position statement from the International PSC Study Group (2017)

Zhu YiZhou, Wang Ying, Zhu Chang, Xu XiaoRong

2018, 34(1): 39-43. DOI: 10.3969/j.issn.1001-5256.2018.01.008

Abstract(274)

PDF (229KB)(136) Cited By (2)

Abstract:

An excerpt of ACR appropriateness criteria chronic liver disease (2017)

Zhou XinMiao, Liu ZhangChun, Zhou Wei, Qi XingShun

2018, 34(1): 44-45. DOI: 10.3969/j.issn.1001-5256.2018.01.009

Abstract(2122)

PDF (1543KB)(435) Cited By (2)

Abstract:

An excerpt of diagnosis and management of paediatric autoimmune liver disease: ESPGHAN Hepatology Committee position statement (2017)

Wang FuChuan, Zhang Min

2018, 34(1): 46-52. DOI: 10.3969/j.issn.1001-5256.2018.01.010

Abstract(249)

PDF (304KB)(196) Cited By (2)

Abstract:

Original articles_Viral hepatitis

Impact of pegylated interferon versus conventional interferon on the change in peripheral CD4+CD25highT cells in patients with chronic hepatitis B

Wang HaiYan, Zhu Li, Wang YinLing, Zhu YuePing, Zhu XiaoYan, Chai XiaoZhe, Qian Feng, Li Ming, Zhu ChuanWu

2018, 34(1): 53-57. DOI: 10.3969/j.issn.1001-5256.2018.01.011

Abstract(466)

PDF (373KB)(98) Cited By (3)

Abstract:

Objective To investigate the impact of pegylated interferon alpha-2 a ( PEG-IFNα-2 a) versus conventional interferon alpha-2 b ( IFNα-2 b) on the change in peripheral CD4+CD25high T cells in patients with chronic hepatitis B ( CHB) . Methods A total of 72 HBeAg-positive CHB patients who received int...

Expression features of follicular helper T cells in peripheral blood in patients with chronic hepatitis B

Wang Yan, Huang YouYing, Ma Yan, Guo Feng, Wang XiaoBo, Wang XiaoZhong

2018, 34(1): 58-62. DOI: 10.3969/j.issn.1001-5256.2018.01.012

Abstract(2308)

PDF (1854KB)(426) Cited By (8)

Abstract:

Objective To investigate the expression features of follicular helper T ( Tfh) cells in peripheral blood in patients with chronic hepatitis B ( CHB) . Methods A total of 53 CHB patients who were admitted to Department of Hepatology in Hospital of Traditional Chinese Medicine Affiliated to Xinjiang M...

Clinical value of Golgi protein 73 and hyaluronic acid in diagnosis of the progression of hepatitis B virus-related chronic liver diseases

Zhang LiJun, Liu MingJun, Wang Shuai, Wang Lin, Wang RuKun, Hou HuaBin, Sun GuiRong, Zhang NaNa, Liu LinJie

2018, 34(1): 63-67. DOI: 10.3969/j.issn.1001-5256.2018.01.013

Abstract(2713)

PDF (1658KB)(507) Cited By (11)

Abstract:
Objective To investigate the clinical value of Golgi protein 73 ( GP73) and hyaluronic acid ( HA) in the diagnosis of the progression of hepatitis B virus ( HBV) -related chronic liver diseases. Methods A total of 142 patients who visited The Affiliated Hospital of Qingdao University from December 2...

Signal mining and analysis of the adverse drug reaction of digestive dysfunction caused by the new anti-HCV drug sofosbuvir

Kou GuoXian, Wang Yu, Guo Jun, Liu Qian

2018, 34(1): 68-72. DOI: 10.3969/j.issn.1001-5256.2018.01.014

Abstract(2261)

PDF (1579KB)(465) Cited By (3)

Abstract:

Objective To investigate the safety of a new anti-HCV drug, sofosbuvir, through mining the adverse drug reaction ( ADR) signals of digestive dysfunction caused by this drug. Methods The reporting odds ratio ( ROR) was used for mining the ADR signals of digestive dysfunction caused by sofosbuvir from...

Original articles_Liver fibrosis and liver cirrhosis

Clinical effect of probiotics in treatment of liver cirrhosis: a Meta-analysis

Sun YuanPei, Guo XiaoXia

2018, 34(1): 73-79. DOI: 10.3969/j.issn.1001-5256.2018.01.015

Abstract(2035)

PDF (2147KB)(493) Cited By (12)

Abstract:

Objective To investigate the clinical effect of probiotics in the treatment of liver cirrhosis through a systematic review. Methods PubMed, Embase, Cochrane Library, Chinese Scientific Journal Full-Text Database, VIP, and Wanfang Data were searched for randomized controlled trials ( RCTs) of probiot...

Clinical value of acoustic radiation force impulse in quantitative prediction of the degree of esophageal varices in patients with liver cirrhosis

Chen Min, Zhang DaKun, Gao YueJuan, Li Meng, Wang RuiFang, Zhang WenHui

2018, 34(1): 80-83. DOI: 10.3969/j.issn.1001-5256.2018.01.016

Abstract(1710)

PDF (1570KB)(390) Cited By (3)

Abstract:

Objective To investigate the clinical value of acoustic radiation force impulse ( ARFI) in quantitative prediction of the degree of esophageal varices in patients with cirrhotic portal hypertension. Methods A total of 116 patients with liver cirrhosis who were admitted to 302 Hospital of PLA from Oc...

Association of platelet count, fibrosis-4, and aspartate aminotransferase-to-platelet ratio index with the development and severity of esophageal varices in patients with liver cirrhosis

Wang Bao, Niu JunQi

2018, 34(1): 84-88. DOI: 10.3969/j.issn.1001-5256.2018.01.017

Abstract(556)

PDF (351KB)(155) Cited By (21)

Abstract:

Objective To investigate the clinical value of platelet count ( PLT) , fibrosis-4 ( FIB-4) , and aspartate aminotransferase-to-platelet ratio index ( APRI) in predicting the development and classification of esophageal varices ( EVs) . Methods A retrospective analysis was performed for the clinical ...

Risk factors for glue extrusion bleeding after endoscopic therapy for esophagogastric variceal bleeding

Ma JiaLi, Li Ping, Wei HongShan, Zhou YuLing, Liang XiuXia, Hu JuLong, Ai ZhengLin, Chen Xu

2018, 34(1): 89-91. DOI: 10.3969/j.issn.1001-5256.2018.01.018

Abstract(1977)

PDF (1553KB)(418) Cited By (7)

Abstract:

Objective To investigate the risk factors for glue extrusion bleeding after endoscopic tissue adhesive injection for the treatment of esophagogastric variceal bleeding. Methods A total of 416 patients with liver cirrhosis complicated by esophagogastric variceal bleeding or a past history of bleeding...

Efficacy of Yunnan white medicinal powder combined with somatostatin and pantoprazole in treatment of liver cirrhosis complicated by upper gastrointestinal bleeding and its effect on inflammatory factors

Zhao JingFeng, Liu Qun, Wang XiuYan, Zhang Yang, Liang LiWei, Gan Yu

2018, 34(1): 92-96. DOI: 10.3969/j.issn.1001-5256.2018.01.019

Abstract(2279)

PDF (1581KB)(436) Cited By (32)

Abstract:

Objective To investigate the efficacy of Yunnan white medicinal powder combined with somatostatin and pantoprazole in the treatment of liver cirrhosis complicated by upper gastrointestinal bleeding and its effect on inflammatory factors. Methods A total of 150 patients with liver cirrhosis complicat...

Clinical effect of octreotide combined with an increased amount of fluid infusion in treatment of intractable cirrhotic ascites

Ge HongYan, Li PeiXia, Zhang YangYang, Wang LiLi, Wei YaoLing

2018, 34(1): 97-100. DOI: 10.3969/j.issn.1001-5256.2018.01.020

Abstract(2596)

PDF (1566KB)(406) Cited By (11)

Abstract:

Objective To investigate the clinical effect of octreotide combined with an increased amount of fluid infusion in the treatment of intractable cirrhotic ascites, and to provide new thoughts for clinical diagnosis and treatment. Methods A total of 65 patients with intractable cirrhotic ascites who vi...

Value of combined measurement of serum cystatin C and urinary neutrophil gelatinase-associated lipocalin in diagnosis of acute kidney injury secondary to cirrhotic ascites

Lei Lei, Li LiangPing, Zhang Hu

2018, 34(1): 101-105. DOI: 10.3969/j.issn.1001-5256.2018.01.021

Abstract(2367)

PDF (1688KB)(459) Cited By (22)

Abstract:

Objective To investigate the value of combined measurement of serum cystatin C ( Cys C) and urinary neutrophil gelatinase-associated lipocalin ( NGAL) in the diagnosis of AKI secondary to cirrhotic ascites. Methods A total of 105 patients with cirrhotic ascites who were admitted to Sichuan Provincia...

Predictive factors for portal vein thrombosis after splenectomy in cirrhotic patients with portal hypertension

Mou SiYu, Yang Zhe, Wu LiQun, Qiu Xuan, Guo JiaMing

2018, 34(1): 106-111. DOI: 10.3969/j.issn.1001-5256.2018.01.022

Abstract(2242)

PDF (1689KB)(449) Cited By (18)

Abstract:

Objective To investigate the cause of portal vein thrombosis ( PVT) after esophagogastric devascularization and splenectomy in cirrhotic patients with portal hypertension ( PH) . Methods A retrospective analysis was performed for the clinical data of 123 patients who were admitted to The Affiliated ...

Screening for differentially expressed proteins in patients with liver cirrhosis complicated by portal vein thrombosis

Xiong JingPing, Peng YuanYuan, Zhang YueXin

2018, 34(1): 112-117. DOI: 10.3969/j.issn.1001-5256.2018.01.023

Abstract(2186)

PDF (1875KB)(438) Cited By (4)

Abstract:

Objective To investigate the differentially expressed serum proteins in patients with liver cirrhosis complicated by portal vein thrombosis ( PVT) . Methods Serum samples were collected from 45 patients with liver cirrhosis who were hospitalized in Infectious Disease Center, The First Affiliated Hos...

Effect of TNF-like weak inducer of apoptosis and its receptor on migration of hepatic stellate cells

Su Min, Zhang Wei, Zhu ChengKai, Zhang Feng, Zhu GeYuZheng

2018, 34(1): 118-121. DOI: 10.3969/j.issn.1001-5256.2018.01.024

Abstract(2276)

PDF (1855KB)(440) Cited By (1)

Abstract:

Objective To investigate the effect of TNF-like weak inducer of apoptosis ( TWAEK) and its receptor fibroblast growth factor-inducible 14 ( Fn14) on the migration of hepatic stellate cells and the possible mechanism. Methods The human hepatic stellate cell line LX-2 cells were treated with TWEAK or ...

Role of phosphatase and tensin homolog deleted on chromosome ten in a rat model of carbon tetrachloride-induced liver fibrosis and the effect of qi-tonifying and blood-activating prescription

Niu XueMin, Wang BaoYu, Wang Yang, Zhao Wen, Fu Na, Zhao SuXian, Du JingHua, Wang RongQi, Zhang YuGuo, Nan YueMin

2018, 34(1): 122-128. DOI: 10.3969/j.issn.1001-5256.2018.01.025

Abstract(2469)

PDF (2848KB)(526) Cited By (22)

Abstract:

Objective To investigate the role of phosphatase and tensin homology deleted on chromosome ten ( PTEN) in a rat model of carbon tetrachloride ( CCl4) -induced liver fibrosis and the molecular mechanism of action of qi-tonifying and blood-activating prescription in regulating PTEN and inhibiting live...

Original articles_Liver neoplasms

Value of Gd-EOB-DTPA-enhanced MRI in diagnosis of hepatocellular carcinoma

Sun Yu, Zhang Nan, Hou Jie, Ma XiangHong, Wang Wei, Yang BenQiang

2018, 34(1): 129-132. DOI: 10.3969/j.issn.1001-5256.2018.01.026

Abstract(2544)

PDF (1809KB)(482) Cited By (9)

Abstract:

Objective To investigate the value of Gd-EOB-DTPA-enhanced MRI in the diagnosis of hepatocellular carcinoma ( HCC) .Methods A total of 40 patients with liver cirrhosis or suspected HCC who visited General Hospital of Shenyang Military Area Command from October 2016 to April 2017 were enrolled, and t...

Feasibility of i Flow color-coding technique in quantitative real-time measurement of hemodynamic changes after transarterial chemoembolization for hepatocellular carcinoma

Wang YuZhe, Yin HuaBin

2018, 34(1): 133-136. DOI: 10.3969/j.issn.1001-5256.2018.01.027

Abstract(2050)

PDF (2233KB)(417) Cited By (4)

Abstract:

Objective To investigate the value of iFlow color-coding technique in quantitative real-time analysis of hemodynamic changes after transarterial chemoembolization ( TACE) for hepatocellular carcinoma ( HCC) . Methods A total of 31 patients who were diagnosed with HCC in Shanghai Fifth People's Hospi...

Clinical effect of transarterial chemoembolization combined with endovascular implantation of iodine-125 seeds in treatment of primary liver cancer complicated by portal vein tumor thrombus

Wang QiaoYu, Pan Jie, Zhou YuanMin

2018, 34(1): 137-141. DOI: 10.3969/j.issn.1001-5256.2018.01.028

Abstract(2366)

PDF (1812KB)(445) Cited By (31)

Abstract:

Objective To investigate the clinical effect of transarterial chemoembolization ( TACE) combined with endovascular implantation of iodine-125 seeds in the treatment of primary liver cancer complicated by portal vein tumor thrombus ( PVTT) and its influence on liver function. Methods A retrospective ...

Clinical effect on microwave coagulo-necrotic therapy combined with laparoscopic splenectomy in treatment of primary hepatocellular carcinoma complicated by hypersplenism

Liu ShuMin, Sun Qiu, Zhang MeiJu

2018, 34(1): 142-146. DOI: 10.3969/j.issn.1001-5256.2018.01.029

Abstract(2118)

PDF (1861KB)(414) Cited By (4)

Abstract:
Objective To investigate the feasibility and safety of microwave coagulo-necrotic therapy ( MCN) combined with laparoscopic splenectomy ( LS) in the treatment of primary hepatocellular carcinoma ( PHC) complicated by hypersplenism. Methods A retrospective analysis was performed for the clinical data...

Original articles_Pancreatic diseases

Clinical features of acute pancreatitis of different etiologies

Wang BeiBei, Liao ShanYing, Ma Juan, Bu XiaoLing, Sha WeiHong

2018, 34(1): 147-151. DOI: 10.3969/j.issn.1001-5256.2018.01.030

Abstract(2287)

PDF (1581KB)(433) Cited By (25)

Abstract:

Objective To investigate the clinical features of acute pancreatitis ( AP) of different etiologies. Methods A retrospective analysis was performed for the clinical data of 150 patients with AP who were admitted to Department of Gastroenterology, Guangdong General Hospital, from January 2014 to Decem...

Clinical significance of abnormal liver function in determining the etiology and severity of acute pancreatitis

Zhao Qi, Wang Bing, Li ZhenFang, Fang ChunFang, Li Cong, Li SenLin

2018, 34(1): 152-156. DOI: 10.3969/j.issn.1001-5256.2018.01.031

Abstract(3253)

PDF (1578KB)(1100) Cited By (18)

Abstract:

Objective To investigate the association of liver function parameters with etiology and severity in patients with acute pancreatitis ( AP) complicated by liver injury, and to clarity the clinical significance of the change in liver function in determining the etiology and severity of AP. Methods A r...

Clinical application of duodenum-preserving pancreatic head resection

Zhou SongQiang, Tian YiFeng, Lai ZhiDe, Qiu FuNan, Yan MaoLin, Wang YaoDong

2018, 34(1): 157-159. DOI: 10.3969/j.issn.1001-5256.2018.01.032

Abstract(2350)

PDF (1648KB)(413) Cited By (5)

Abstract:

Objective To investigate the indications and therapeutic effect of duodenum-preserving pancreatic head resection ( DPPHR) .Methods A retrospective analysis was performed for the clinical data of 17 patients who underwent DPPHR in Fujian Provincial Hospital from January 2013 to February 2017. Among t...

Expression of Sema4D and Ki67 in pancreatic carcinoma and its relationship with clinicopathological features

Jia RuJiang, Hou LiYan, Yin QingChen

2018, 34(1): 160-163. DOI: 10.3969/j.issn.1001-5256.2018.01.033

Abstract(2010)

PDF (1693KB)(423) Cited By (5)

Abstract:

Objective To investigate the expression of Sema4 D and Ki67 in pancreatic carcinoma and its relationship with clinicopathological features. Methods The expression of Sema4 D and Ki67 in 40 pancreatic carcinoma tissues and 10 adjacent tissues was measured by immunohistochemistry, and its relationship...

Original articles_Others

Detection rates of autoantibodies in patients with drug-induced liver injury and their clinical significance

Jiang HongLi, Qi YaBin, Zhang Rui, Hu YuLin

2018, 34(1): 164-167. DOI: 10.3969/j.issn.1001-5256.2018.01.034

Abstract(1686)

PDF (1563KB)(388) Cited By (16)

Abstract:

Objective To investigate the detection rates of autoantibodies in patients with drug-induced liver injury ( DILI) and their clinical significance. Methods A total of 132 patients with DILI who were admitted to The First Hospital of Jilin University from January 2009 to December 2013 were enrolled, a...

Case reports

Antiviral therapy using sofosbuvir combined with ribavirin after transcatheter arterial chemoembolization for hepatitis C virus-related hepatocellular carcinoma with tumor thrombus in the right atrium: a case report

Li CuiCui, Ma JingTing, Zhou He, Hu RongRong, Wang Kai, Li DongFu

2018, 34(1): 168-171. DOI: 10.3969/j.issn.1001-5256.2018.01.035

Abstract(1931)

PDF (2004KB)(402) Cited By (1)

Abstract:

Hepatic perivascular epithelioid cell tumor (PEComa): a case report and literature review

Gao WeiKe, Dai ChaoLiu

2018, 34(1): 172-176. DOI: 10.3969/j.issn.1001-5256.2018.01.036

Abstract(1815)

PDF (2434KB)(438) Cited By (6)

Abstract:

Multiple metastases of malignant melanoma: a case report

Kui YiWen, Wen XiaoYu, Wang Yao, Xu XiJing, Jin QingLong

2018, 34(1): 177-178. DOI: 10.3969/j.issn.1001-5256.2018.01.037

Abstract(2028)

PDF (1937KB)(451) Cited By (1)

Abstract:

A case report of benign recurrent intrahepatic cholestasis

Chai XiaoZhe, Zhu Wei, Luo XiangRong, Qian Feng, Zhu ChuanWu

2018, 34(1): 179-180. DOI: 10.3969/j.issn.1001-5256.2018.01.038

Abstract(2057)

PDF (1536KB)(383) Cited By (2)

Abstract:

Reviews

Relationship between the Notch signaling pathway and the development and progression of liver fibrosis

Zhang Xu, Liu Ping, Mu YongPing

2018, 34(1): 181-183. DOI: 10.3969/j.issn.1001-5256.2018.01.039

Abstract(1661)

PDF (1609KB)(388) Cited By (10)

Abstract:

The Notch signaling pathway mainly includes Notch receptors and ligands, transcription factors, and DNA binding proteins. It decides the way of cell proliferation, differentiation, and apoptosis. Recent studies have shown that the Notch signaling pathway plays an important role in the development an...

Advances in the effect of carvedilol in prevention and treatment of esophageal variceal bleeding in patients with cirrhosis

Niu XiaoWei, Liu TongTing, Wei Zhi

2018, 34(1): 184-187. DOI: 10.3969/j.issn.1001-5256.2018.01.040

Abstract(4710)

PDF (1574KB)(418) Cited By (5)

Abstract:

Carvedilol is a new non-selective beta blocker, and studies have proven that the effect of carvedilol in receptor blocking is 2-4 times that of propranolol. Carvedilol is widely used in the treatment of heart failure. However, there are still controversies over its effect in reducing portal pressure...

Anesthetic management strategies for patients with cirrhotic portal hypertension

Wang Lin, Xu JiPing, Liu Jing, Ma XianChun, Sun WenBing

2018, 34(1): 188-191. DOI: 10.3969/j.issn.1001-5256.2018.01.041

Abstract(2310)

PDF (1564KB)(431) Cited By (6)

Abstract:

Patients with cirrhotic portal hypertension tend to develop multiple organ dysfunction and have special requirements for anesthetic management, which involves disorders in the metabolism of anesthetics, hyperdynamic circulation, perioperative hypoxemia, coagulation disorder, bleeding, thrombosis, an...

Research advances in the influence of hepatic stellate cells on precancerous lesions of liver cirrhosis and hepatocellular carcinoma via the TGFβ1-PI3K/AKT signaling pathway

Ju Di, Li JingTao, Han Man, Wei HaiLiang, Yan ShuGuang, Li Mi, Shi XiaoYan, Chang ZhanJie

2018, 34(1): 192-194. DOI: 10.3969/j.issn.1001-5256.2018.01.042

Abstract(2165)

PDF (1793KB)(398) Cited By (18)

Abstract:

The malignant transformation of the precancerous lesions of liver cirrhosis and hepatocellular carcinoma ( HCC) leads to the formation of liver cancer. Hepatic stellate cells ( HSCs) play a role in the production of cells in precancerous lesions of HCC, the formation of hepatic fibrosis microenviron...

Current status of non-surgical local therapies for hepatocellular carcinoma originating from the caudate lobe and related research advances

Yao ChangYu, Du YingRui, Ke Shan, Gao Jun, Sun WenBing

2018, 34(1): 195-198. DOI: 10.3969/j.issn.1001-5256.2018.01.043

Abstract(1887)

PDF (1570KB)(343) Cited By (3)

Abstract:

Hepatocellular carcinoma originating from the caudate lobe is a special type of hepatocellular carcinoma, and surgical resection is a conventional therapeutic method for this disease. However, the special anatomical position and complex structure of the caudate lobe make it difficult to perform surg...

Research advances in tumor markers for the diagnosis of hepatocellular carcinoma

Yang GuiMin, Zhao YunSheng, Wang ChunHua, Jin Liang

2018, 34(1): 199-203. DOI: 10.3969/j.issn.1001-5256.2018.01.044

Abstract(2753)

PDF (1579KB)(521) Cited By (16)

Abstract:
Hepatocellular carcinoma ( HCC) is a malignant tumor with a high fatality rate in the world, and alpha-fetoprotein ( AFP) is the most commonly used tumor marker for HCC diagnosis. However, AFP does not have a satisfactory sensitivity or specificity and may lead to missed diagnosis when the tumor is ...

A preliminary study of the pathogenesis of malnutrition in patients with hepatic alveolar echinococcosis

Ma Bao, Deng Yong, Wang ZhiXin, Wang HaiJiu, Fan HaiNing

2018, 34(1): 204-206. DOI: 10.3969/j.issn.1001-5256.2018.01.045

Abstract(1850)

PDF (1546KB)(351) Cited By (5)

Abstract:

Hepatic echinococcosis has become a major threat to human health. Hepatic alveolar echinococcosis caused by Echinococcus multilocularis infection has the features of slow and insidious onset, a high probability of surgery, slow postoperative recovery, and many complications and thus does great harm ...