中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2018

Clinical effect of octreotide combined with an increased amount of fluid infusion in treatment of intractable cirrhotic ascites

DOI: 10.3969/j.issn.1001-5256.2018.01.020
  • Published Date: 2018-01-20
  • Objective To investigate the clinical effect of octreotide combined with an increased amount of fluid infusion in the treatment of intractable cirrhotic ascites, and to provide new thoughts for clinical diagnosis and treatment. Methods A total of 65 patients with intractable cirrhotic ascites who visited Affiliated Hospital of Inner Mongolia University for The Nationalities from February 2016 to May 2017 were enrolled and randomly divided into control group with 31 patients and observation group with 34 patients. The patients in the control group were given conventional treatment, and those in the observation group were given continuous pumping of octreotide 0. 6 mg once every 12 hours for 3 days, followed by intramuscular injection of octreotide 0. 2 mg once every 8 hours for 7-10 consecutive days, and an increased amount of fluid infusion, in addition to the conventional treatment. Symptomatic treatment was given based on patients' symptoms and tolerance. Vital signs, abdominal circumference, body weight, and time to ascites regression were observed during treatment, and the length of hospital stay and incidence rate of complications were analyzed. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. Results Compared with the control group, the observation group had significantly shorter time to ascites regression ( 6. 13 ± 1. 25 d vs 11. 61 ± 1. 34 d, t =-4. 06, P < 0. 001) and length of hospital stay ( 10. 01 ± 1. 46 d vs 16. 10 ± 1. 57 d, t =-7. 65, P < 0. 001) , as well as significantly greater average daily reductions in abdominal circumference ( 4. 01 ± 0. 75 cm vs 2. 42 ± 0. 35 cm, t = 4. 69, P < 0. 001) and body weight ( 1. 67 ± 0. 42 kg vs 0. 97 ± 0. 54 kg, t = 4. 58, P < 0. 001) . The observation group had significantly lower incidence rates of upper gastrointestinal bleeding and electrolyte disturbance than the control group ( upper gastrointestinal bleeding: 5. 88% vs 32. 26% , χ2= 7. 49, P < 0. 05; electrolyte disturbance: 8. 82% vs 38. 71% , χ2= 8. 56, P < 0. 05) . Conclusion In addition to the conventional treatment of intractable ascites, octreotide combined with an increased amount of fluid infusion can promote spontaneous dieresis, significantly reduce the amount of ascites, shorten the time to ascites regression, reduce complications, and improve patients' conditions.

     

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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 6.3 %其他: 6.3 %其他: 0.6 %其他: 0.6 %China: 0.6 %China: 0.6 %Congo: 0.1 %Congo: 0.1 %Croatia (LOCAL Name: Hrvatska): 0.3 %Croatia (LOCAL Name: Hrvatska): 0.3 %Falls Church: 0.1 %Falls Church: 0.1 %Hong Kong, China: 0.1 %Hong Kong, China: 0.1 %India: 0.3 %India: 0.3 %Seattle: 0.2 %Seattle: 0.2 %United States: 0.6 %United States: 0.6 %[]: 0.6 %[]: 0.6 %上海: 4.4 %上海: 4.4 %东莞: 0.1 %东莞: 0.1 %丽水: 0.6 %丽水: 0.6 %佛山: 0.1 %佛山: 0.1 %六安: 0.1 %六安: 0.1 %北京: 5.1 %北京: 5.1 %南京: 3.0 %南京: 3.0 %南宁: 0.1 %南宁: 0.1 %南阳: 0.1 %南阳: 0.1 %厦门: 0.1 %厦门: 0.1 %台州: 1.5 %台州: 1.5 %吉林: 0.4 %吉林: 0.4 %吉隆坡: 0.1 %吉隆坡: 0.1 %呼和浩特: 0.1 %呼和浩特: 0.1 %哈尔滨: 0.2 %哈尔滨: 0.2 %哥伦布: 0.1 %哥伦布: 0.1 %嘉兴: 0.1 %嘉兴: 0.1 %大连: 0.4 %大连: 0.4 %天津: 0.2 %天津: 0.2 %太原: 0.1 %太原: 0.1 %孝感: 0.1 %孝感: 0.1 %宁波: 0.1 %宁波: 0.1 %常德: 0.1 %常德: 0.1 %广州: 1.2 %广州: 1.2 %开封: 0.2 %开封: 0.2 %张家口: 1.8 %张家口: 1.8 %悉尼: 0.1 %悉尼: 0.1 %成都: 0.5 %成都: 0.5 %晋城: 0.1 %晋城: 0.1 %杭州: 1.0 %杭州: 1.0 %武汉: 0.4 %武汉: 0.4 %沈阳: 0.2 %沈阳: 0.2 %海得拉巴: 0.1 %海得拉巴: 0.1 %淮南: 0.1 %淮南: 0.1 %湖州: 1.1 %湖州: 1.1 %湘潭: 0.1 %湘潭: 0.1 %漯河: 0.2 %漯河: 0.2 %福州: 0.4 %福州: 0.4 %约翰内斯堡: 0.3 %约翰内斯堡: 0.3 %绍兴: 0.1 %绍兴: 0.1 %芒廷维尤: 30.8 %芒廷维尤: 30.8 %芝加哥: 0.4 %芝加哥: 0.4 %苏州: 0.2 %苏州: 0.2 %莫斯科: 1.3 %莫斯科: 1.3 %萨格勒布: 0.1 %萨格勒布: 0.1 %衡阳: 0.1 %衡阳: 0.1 %衢州: 0.6 %衢州: 0.6 %西宁: 25.8 %西宁: 25.8 %西安: 0.8 %西安: 0.8 %贵阳: 0.1 %贵阳: 0.1 %赤峰: 0.2 %赤峰: 0.2 %运城: 1.0 %运城: 1.0 %郑州: 0.5 %郑州: 0.5 %金华: 0.1 %金华: 0.1 %长春: 2.2 %长春: 2.2 %长沙: 0.6 %长沙: 0.6 %长治: 0.1 %长治: 0.1 %青岛: 0.2 %青岛: 0.2 %驻马店: 0.1 %驻马店: 0.1 %高雄: 0.1 %高雄: 0.1 %黄冈: 0.1 %黄冈: 0.1 %其他其他ChinaCongoCroatia (LOCAL Name: Hrvatska)Falls ChurchHong Kong, ChinaIndiaSeattleUnited States[]上海东莞丽水佛山六安北京南京南宁南阳厦门台州吉林吉隆坡呼和浩特哈尔滨哥伦布嘉兴大连天津太原孝感宁波常德广州开封张家口悉尼成都晋城杭州武汉沈阳海得拉巴淮南湖州湘潭漯河福州约翰内斯堡绍兴芒廷维尤芝加哥苏州莫斯科萨格勒布衡阳衢州西宁西安贵阳赤峰运城郑州金华长春长沙长治青岛驻马店高雄黄冈

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