2019 No. 8

Abuduxikuer Kuerbanjiang, Wang JianShe

2019, 35(8): 1657-1662. DOI: 10.3969/j.issn.1001-5256.2019.08.001

Abstract(1764)

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Abstract:

With the improvement in quality of life and the level of prevention and treatment of viral hepatitis, as well as the availability of genetic testing, genetic liver disorders have been taken more and more seriously. Genetic liver disorders have various clinical manifestations, such as abnormalities i...

Clinical features and diagnosis of inherited metabolic liver disease

Peng ShanShan, Yang YongFeng

2019, 35(8): 1663-1666. DOI: 10.3969/j.issn.1001-5256.2019.08.002

Abstract(2035)

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Abstract:
Inherited metabolic liver disease has complex etiologies and various types, and its clinical manifestations lack specificity, which may lead to missed diagnosis and misdiagnosis. A clinical diagnosis should be given based on symptoms, signs, laboratory examination, imaging findings, liver biopsy, an...

Pathogenic mechanism and clinical diagnosis of hereditary abnormal copper metabolism

Chen ShuRu, Chong YuTian, Li XinHua

2019, 35(8): 1667-1672. DOI: 10.3969/j.issn.1001-5256.2019.08.003

Abstract(2066)

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Abstract:
Copper is an important trace element in the human body, and copper deficiency or overload can lead to a series of body dysfunctions. This review focuses on hepatolenticular degeneration and related diseases of abnormal copper metabolism. Hepatolenticular degeneration has various clinical phenotypes,...

Genetic diagnosis of hereditary hemochromatosis

Han Yue, Zhang XinXin

2019, 35(8): 1673-1679. DOI: 10.3969/j.issn.1001-5256.2019.08.004

Abstract(1905)

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Abstract:
Iron overload is not rarely seen in clinical practice, and hemochromatosis involving the liver is the most common type of iron overload. There is an extremely low incidence rate of the classic form of HFE hereditary hemochromatosis in the Asian population, which is different from the genetic backgro...

Clinical features and diagnosis of four common types of congenital hyperbilirubinemia

Bai Jie, Zheng SuJun, Duan ZhongPing

2019, 35(8): 1680-1683. DOI: 10.3969/j.issn.1001-5256.2019.08.005

Abstract(2661)

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Abstract:
Congenital hyperbilirubinemia is an inherited metabolic liver disease commonly seen in clinical practice, and various atypical manifestations of this disease and a low degree of emphasis may lead to missed diagnosis, misdiagnosis, and delayed diagnosis. This article summarizes the clinical features,...

Congenital disorders of glycosylation and liver diseases

Abuduxikuer Kuerbanjiang, Wang JianShe

2019, 35(8): 1684-1689. DOI: 10.3969/j.issn.1001-5256.2019.08.006

Abstract(2390)

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Abstract:

Congenital disorders of glycosylation (CDGs) is a group of inherited metabolic diseases caused by abnormal glycosylation of protein or lipids, and the number of CDGs are increasing rapidly in recent years. With the advent and popularization of next-generation sequencing, more and more disorders asso...

Research advances in the pathogenesis, clinical manifestations, and diagnosis/treatment of sodium-taurocholate cotransporting polypeptide deficiency

Song YuanZong

2019, 35(8): 1690-1692. DOI: 10.3969/j.issn.1001-5256.2019.08.007

Abstract(2760)

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Abstract:
Sodium-taurocholate cotransporting polypeptide (NTCP) deficiency is a new hereditary bile acid metabolic disease due to biallelic mutations of the SLC10 A1 gene and is not rare in China. Marked and persistent hypercholanemia in childhood is the major clinical feature of NTCP deficiency, and this con...

The expert consensus on clinical cure (functional cure) of chronic hepatitis B

Chinese Society of Infectious Disease, Chinese Society of Hepatology, Chinese Medical Association

2019, 35(8): 1693-1701. DOI: 10.3969/j.issn.1001-5256.2019.08.008

Abstract(2299)

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Abstract:

Chronic hepatitis B virus (HBV) infection remains a major world public health problem. Current guidelines for the prevention and treatment of chronic hepatitis B (CHB) have suggested clinical cure (also known as functional cure) as the ideal therapeutic goal, which is associated with decreased risk ...

An excerpt of the 2019 World Gastroenterology Organisation clinical practice guidelines: Diagnosis and treatment of pancreatic cystic lesions

Wang LeJunZi, Zhu RuiZhe, Zhang TaiPing, Zhao YuPei

2019, 35(8): 1702-1705. DOI: 10.3969/j.issn.1001-5256.2019.08.009

Abstract(643)

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Abstract:

An excerpt of hepatitis B management during immunosuppression for haematological and solid organ malignancies: An Australian consensus statement 2019

Sun MengYing, Wang Shuai, Tang ShanHong, Zeng WeiZheng

2019, 35(8): 1706-1707. DOI: 10.3969/j.issn.1001-5256.2019.08.010

Abstract(341)

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Abstract:

An excerpt of Wilson’s disease: Clinical practice guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India (2019)

Wang Le, Deng BaoCheng, Qi XingShun

2019, 35(8): 1708-1709. DOI: 10.3969/j.issn.1001-5256.2019.08.011

Abstract(354)

PDF (135KB)(217) Cited By (2)

Abstract:

Screening for hepatitis C virus infection in Peking University People's Hospital in 2015-2018

Kong XiangSha, Yang RuiFeng, Zhang HaiYing, Ji Ying, Zhu Ling, Liu Yan, Wei Lai

2019, 35(8): 1710-1713. DOI: 10.3969/j.issn.1001-5256.2019.08.012

Abstract(1364)

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Abstract:
Objective To investigate missed detection in the screening for hepatitis C virus (HCV) infection in a general hospital in 2015-2018. Methods A retrospective analysis was performed for the data of 3659 patients who attended People's Hospital, Peking University, from 2015 to 2018 and underwent the det...

Clinical effect and safety of sofosbuvir-based regimens in treatment of hepatitis C virus-associated glomerulonephritis

He CaiNi, Li Yu, Ge Heng, Wei Fu, Ma XiaoTao, Wang WenJun, Gao Ning, Duan ChaoYang, Ji FanPu

2019, 35(8): 1714-1718. DOI: 10.3969/j.issn.1001-5256.2019.08.013

Abstract(1404)

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Abstract:

Objective To investigate the clinical effect and safety of sofosbuvir-based regimens in the treatment of hepatitis C virus (HCV) -associated glomerulonephritis (HCV-GN) . Methods A retrospective analysis was performed for the clinical data of 5 patients with HCV-GN who were given sofosbuvir-based an...

Safety and efficacy of flow-reducing stent in treatment of recurrent or persistent hepatic encephalopathy after transjugular intrahepatic portosystemic shunt

He ChuangYe, Chen Hui, Lyu Yong, Xia DongDong, Yu TianLei, Yuan XuLong, Li Kai, Wang ZhengYu, Niu Jing, Bai Wei, Guo WenGang, Tie Jun, Yin ZhanXin, Han GuoHong

2019, 35(8): 1719-1722. DOI: 10.3969/j.issn.1001-5256.2019.08.014

Abstract(1419)

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Abstract:

Objective To investigate the safety and efficacy of flow-reducing stent in the treatment of recurrent or persistent hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) . Methods A total of 11 patients who were diagnosed with recurrent or persistent HE after TIPS in...

Influence of dual positivity of HBsAg and anti-HBs on the development of hepatocellular carcinoma in patients with chronic hepatitis B: A Meta-analysis

Fan MengJie, Zeng Zheng

2019, 35(8): 1723-1727. DOI: 10.3969/j.issn.1001-5256.2019.08.015

Abstract(480)

PDF (314KB)(100) Cited By (4)

Abstract:

Objective To investigate the influence of dual positivity of HBsAg and anti-HBs on the development of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection. Methods PubMed, Embase, Cochrane Library, CNKI, and Wanfang Data were searched for articles on the influence of dua...

Effect of cryoablation versus microwave ablation on clinical indices and cytokines in patients with hepatocellular carcinoma

Xiang Jiao, Jia XiaoDong, Lu ShanShan, Wu DaWei, Zhang Ting, Dong JinKe, Huang JiaGan, Li YinYin, Yang Bin, Xu Yong, Dong Zheng, Lu Ying, Zeng Zhen, Lu YinYing

2019, 35(8): 1728-1733. DOI: 10.3969/j.issn.1001-5256.2019.08.016

Abstract(1344)

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Abstract:

Objective To investigate the changes in clinical indices and cytokines in peripheral blood after cryoablation or microwave ablation in patients with hepatocellular carcinoma (HCC) and related clinical significance. Methods A total of 62 patients with HCC who were admitted to The Fifth Medical Center...

Expression of TM6SF2 in hepatocellular carcinoma tissue and its bioinformatics functions

Xiao JianHan, Liu ShouSheng, Zhao ZhenZhen, Xin YongNing, Xuan ShiYing

2019, 35(8): 1734-1739. DOI: 10.3969/j.issn.1001-5256.2019.08.017

Abstract(1661)

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Abstract:

Objective To investigate the expression of TM6 SF2 in hepatocellular carcinoma (HCC) tissue and its biological functions by data mining in tumor databases. Methods The GEPIA database was applied to measure the change in the mRNA expression level of TM6 SF2 in HCC tissue, and OncoLnc was used to anal...

Construction and functional enrichment analysis of circRNA-miRNA-mRNA regulatory network for liver cancer based on high-throughput sequencing

Zhao Jing, Yang XingWu, Li JingTao, Wang Qi, Wang Liang, Wang GuoTai

2019, 35(8): 1740-1744. DOI: 10.3969/j.issn.1001-5256.2019.08.018

Abstract(762)

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Abstract:

Objective To construct a protein interaction network based on high-throughput sequencing data of liver cancer-related non-coding RNAs, to perform a functional enrichment analysis, and to screen out circular RNAs (circRNAs) participating in the development and progression of liver cancer via the mech...

Association of serum high-density lipoprotein cholesterol with new-onset cholelithiasis

Sun MiaoMiao, Cao LiYing, Sun WeiDong, Liu XiNing, Cui HaoZhe, Liang MingYang, Wei YaoChen, Wang WanChao, Liu SiQing

2019, 35(8): 1745-1750. DOI: 10.3969/j.issn.1001-5256.2019.08.019

Abstract(1466)

PDF (2118KB)(271) Cited By (36)

Abstract:
Objective To investigate the influence of serum high-density lipoprotein cholesterol (HDL-C) level on new-onset cholelithiasis. Methods A prospective cohort study was conducted. The physical examination data of 87 891 on-the-job and retired workers in Kailuan Group were collected from July 2006 to D...

Role of 99mTc-EHIDA hepatobiliary scintigraphy in the eraluation of gallbladder contraction function before laparoscopic-hard endoscopic gallbladder-preserving cholecystolithotomy

Duan DongFeng, Yang ZhenYu, Du XiLin, Wang Qing, Lu JianGuo

2019, 35(8): 1751-1754. DOI: 10.3969/j.issn.1001-5256.2019.08.020

Abstract(1497)

PDF (2219KB)(270) Cited By (6)

Abstract:
Objective To investigate the role of radionuclide hepatobiliary scintigraphy in the evaluation of gallbladder contraction function, and to provide a theoretical basis for preoperative evaluation of gallbladder contraction function in patients undergoing laparoscopic-hard endoscopic gallbladder-prese...

Value of Nutritional Risk Screening 2002 and Mini Nutritional Assessment-Short Form in predicting the survival time of patients with malignant obstructive jaundice after surgery

Han ShanShan, Zhao JunHui, Ye Jun, Liu Rui, Chen WeiWei, Feng ZhiQiang

2019, 35(8): 1755-1759. DOI: 10.3969/j.issn.1001-5256.2019.08.021

Abstract(1535)

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Abstract:
Objective To investigate the value of Nutritional Risk Screening 2002 (NRS-2002) and Mini Nutritional Assessment-Short Form (MNA-SF) in assessing the nutritional status of patients with malignant obstructive jaundice (MOJ) and their association with overall survival (OS) after surgery. Methods A tot...

Clinical effect of different methods for endoscopic precut sphincterotomy in difficult intubation during endoscopic retrograde cholangiopancreatography: A comparative analysis

Shi BaoPing, Fu Yan, Lu MingLiang, Liu GuoBin, Li XinHua, Wei Li, Hu YiTao, Yang Juan

2019, 35(8): 1760-1765. DOI: 10.3969/j.issn.1001-5256.2019.08.022

Abstract(1400)

PDF (1949KB)(234) Cited By (16)

Abstract:
Objective To investigate the clinical characteristics of different methods for endoscopic precut sphincterotomy in difficult intubation during endoscopic retrograde cholangiopancreatography (ERCP) . Methods A retrospective analysis was performed for the clinical data of 185 patients who underwent ER...

Role of CT signs of thoracoabdominal complications, serum calcium, and serum C-reactive protein in evaluating disease severity in patients with acute pancreatitis

Li ManHua, Zhang Wen, Xiang XiaoHui, Xu Wei, Xia ShiHai

2019, 35(8): 1766-1769. DOI: 10.3969/j.issn.1001-5256.2019.08.023

Abstract(1390)

PDF (2479KB)(245) Cited By (28)

Abstract:
Objective To investigate the role of CT signs of thoracoabdominal complications, serum calcium, and serum C-reactive protein (CRP) in evaluating disease severity in patients with acute pancreatitis (AP) . Methods A retrospective analysis was performed for the results of thoracoabdominal CT and blood...

Clinical value of the measurement of intra-abdominal pressure, C-reactive protein, and procalcitonin in patients with acute pancreatitis in late pregnancy

Liao WenYan, Yang ChunFen, Qin YongXi, He Jun, Ding ChengMing

2019, 35(8): 1770-1774. DOI: 10.3969/j.issn.1001-5256.2019.08.024

Abstract(1231)

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Abstract:

Objective To investigate the clinical value of the measurement of intra-abdominal pressure (IAP) , C-reactive protein (CRP) , and procalcitonin (PCT) in patients with acute pancreatitis in late pregnancy. Methods A total of 80 patients with acute pancreatitis in late pregnancy (≥28 gestational weeks...

Clinical effect of Silybum marianum preparation in the prophylactic treatment of antitubercular agent-induced liver injury: A Meta-analysis of randomized controlled trials

Tao LiNa, Qu XiaoYu, Zhang Yue, Song YanQing, Zhang SiXi

2019, 35(8): 1775-1781. DOI: 10.3969/j.issn.1001-5256.2019.08.025

Abstract(1902)

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Abstract:

Objective To evaluate the clinical effect of Silybum marianum preparation in the prophylactic treatment of antitubercular agent-induced liver injury (ATB-DILI) , since there have always been controversies over the development of Silybum marianum preparation for the prophylactic treatment of ATB-DILI...

Correlation of severity of infantile cholestatic liver disease with serum vitamin D level

Huang CaiZhi, Nie BoLi, Tang Lian, Mo LiYa

2019, 35(8): 1782-1785. DOI: 10.3969/j.issn.1001-5256.2019.08.026

Abstract(1520)

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Abstract:

Objective To investigate the correlation of serum 25-hydroxy vitamin D[25 (OH) D]level with the severity of infantile cholestatic hepatopathy (ICH) . Methods A total of 121 infants with ICH who were admitted or referred to Liver Research Center in our hospital from July 2015 to December 2017 were en...

Value of second harmonic generation/two-photon excitation fluorescence in quantitative evaluation of liver fibrosis in mice with nonalcoholic fatty liver disease

Wang XiaoXiao, Zhao Jie, Li XiaoHe, Rao HuiYing, Wei Lai, Liu Feng

2019, 35(8): 1786-1790. DOI: 10.3969/j.issn.1001-5256.2019.08.027

Abstract(1576)

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Abstract:

Objective To investigate the dynamic changes in collagen parameters in mice with nonalcoholic fatty liver disease (NAFLD) by second harmonic generation (SHG) /two-photon excitation fluorescence (TPEF) , to establish the parameters for automatic quantitative evaluation of mice with NAFLD induced by m...

Role of the specific inhibitor of 5-lipoxygenase-activating protein MK886 in inhibiting alcoholic liver disease in mice

Yang ShuJuan, Guo YaLing, Fu Shan, He YingLi, Zhao YingRen, Tian Zhen

2019, 35(8): 1791-1796. DOI: 10.3969/j.issn.1001-5256.2019.08.028

Abstract(1448)

PDF (2715KB)(241) Cited By (2)

Abstract:

Objective To investigate the effect of MK886, a specific inhibitor of 5-lipoxygenase-activating protein (FLAP) , on alcoholic liver disease (ALD) in mice. Methods A total of 48 male Kunming mice were randomly divided into ALD group, ALD/MK886 group, control group, and normal group. The mice in the A...

Hepatitis-associated aplastic anemia in children: A case report

Mu Jing, Chen Fang, He Qiang

2019, 35(8): 1797-1799. DOI: 10.3969/j.issn.1001-5256.2019.08.029

Abstract(1042)

PDF (1905KB)(254) Cited By (6)

Abstract:

Senile intestinal lymphangiectasia with drug-induced liver injury: A case report

Kong XiaoLu, Shao Xue, Li DongFu

2019, 35(8): 1800-1802. DOI: 10.3969/j.issn.1001-5256.2019.08.030

Abstract(1080)

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Abstract:

A case of chronic drug-induced liver injury caused by psoralen decoction

Meng CunYing, Liu Jia, Cao Dan, Chen WenJing, Yuan BeiBei, Dong Bing, Ji Dong, Chen YanPing

2019, 35(8): 1803-1805. DOI: 10.3969/j.issn.1001-5256.2019.08.031

Abstract(1160)

PDF (2293KB)(233) Cited By (1)

Abstract:

Autoantibody-negative autoimmune hepatitis overlapping with primary biliary cholangitis and primary sclerosing cholangitis: A case report

Meng Miao, Hu Zhen, Gong Lei, Lu ZhongHua, Peng XiaoBin, Tang XueJun, Wang XiaoYun

2019, 35(8): 1806-1808. DOI: 10.3969/j.issn.1001-5256.2019.08.032

Abstract(1658)

PDF (2217KB)(250) Cited By (3)

Abstract:

Polymyositis misdiagnosed as autoimmune liver disease: A case report

Zhang LiJuan, Gao YinJie, Zhou Xia, He Xi, Feng DanNi, Zhang DaLi, Liu HongLing

2019, 35(8): 1809-1810. DOI: 10.3969/j.issn.1001-5256.2019.08.033

Abstract(1334)

PDF (1992KB)(239) Cited By (3)

Abstract:

X-linked lymphoproliferative disease type 2 with cholestatic liver disease as initial manifestation: A case report

Zhou Fang, Li XiaoQin, Wang RuiFeng, Sun Bo

2019, 35(8): 1811-1814. DOI: 10.3969/j.issn.1001-5256.2019.08.034

Abstract(1118)

PDF (2272KB)(215) Cited By (1)

Abstract:

A case of retroperitoneal Castleman's disease

Ren XueKang, Wang ShuPeng, Wang ShouQian, Liu YaHui

2019, 35(8): 1815-1816. DOI: 10.3969/j.issn.1001-5256.2019.08.035

Abstract(1043)

PDF (2205KB)(241) Cited By (2)

Abstract:

Hepatic space-occupying lesions caused by Trichinella: A case report

Tian Bing, Liu MeiLi, Deng BaoCheng

2019, 35(8): 1817-1818. DOI: 10.3969/j.issn.1001-5256.2019.08.036

Abstract(1169)

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Abstract:

Neuroendocrine carcinoma of the extrahepatic bile duct: A report of 2 cases

Wang ShuPeng, Su JingHan, Wang ShouQian, Xu HongJi, Liu YaHui

2019, 35(8): 1819-1820. DOI: 10.3969/j.issn.1001-5256.2019.08.037

Abstract(1156)

PDF (2401KB)(228) Cited By (1)

Abstract:

Value of HBsAg quantification in individualized anti-HBV treatment with nucleos (t) ide analogues

Zhou YouQian, Li Cui

2019, 35(8): 1821-1823. DOI: 10.3969/j.issn.1001-5256.2019.08.038

Abstract(1234)

PDF (1919KB)(386) Cited By (7)

Abstract:
Nucleos (t) ide analogues can effectively prevent or delay disease progression in patients with chronic hepatitis B virus (HBV) infection, but the course of treatment is long and long-term medication may bring the risk of adverse drug reactions and drug resistance. Recent studies have found that HBs...

Research advances in the diagnosis and treatment of patients in the immune tolerance stage of chronic hepatitis B virus infection

Zhou LuLu, Liu Na, Li ChunXia, Dong Bing, Bai XiaoXiao, Zhang Nan, Xu GuangHua

2019, 35(8): 1824-1827. DOI: 10.3969/j.issn.1001-5256.2019.08.039

Abstract(1190)

PDF (1927KB)(248) Cited By (1)

Abstract:
Patients in the immune tolerance stage of chronic hepatitis B virus (HBV) infection are in a state of high viral replication and low inflammation in the liver, and they often have no disease progression. Therefore, antiviral therapy is not recommended in related guidelines.Recent studies have found ...

Research advances in the clinical effect of tenofovir alafenamide in treatment of chronic hepatitis B

Wang SuNa, Lian JianQi, Jia ZhanSheng, Zhang Ying

2019, 35(8): 1828-1833. DOI: 10.3969/j.issn.1001-5256.2019.08.040

Abstract(3542)

PDF (2004KB)(589) Cited By (55)

Abstract:
Tenofovir alafenamide (TAF) is a novel nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV) infection and chronic hepatitis B virus (HBV) infection. Compared with tenofovir disoproxil fumarate, TAF has better plasma stability and stronger liver-targe...

Association of biological characteristics of hepatitis B virus with the progression of liver fibrosis

Chang XiuJuan, Li YinYin, Yang Bin, Ceng Zhen, Huang JiaGan, Yang YongPing

2019, 35(8): 1834-1837. DOI: 10.3969/j.issn.1001-5256.2019.08.041

Abstract(1109)

PDF (1929KB)(225) Cited By (7)

Abstract:
Hepatitis B virus (HBV) causes liver injury by stimulating host immune response and may lead to liver fibrosis, liver cirrhosis, and liver cancer. Progression of liver fibrosis is a key factor in liver disease-related death. This article summarizes the association of HBV genotype, HBV gene mutation ...

Current status of the imaging diagnosis of liver fibrosis

Zheng You, Xu YongSheng, Zhang XuXia, Liu HaiFeng, Liu Zhao, Lei JunQiang

2019, 35(8): 1838-1841. DOI: 10.3969/j.issn.1001-5256.2019.08.042

Abstract(1112)

PDF (1933KB)(244) Cited By (16)

Abstract:

Liver fibrosis is the result of the progressive development of various chronic liver diseases and can develop into liver cirrhosis and liver cancer with high mortality rates. Early diagnosis of liver fibrosis is of great significance for disease reversal. At present, liver biopsy is considered the g...

Role of FOXO1/3 in the pathogenesis of hepatic fibrosis

Li Tian, Wu Yan, Ji Ting, Jin ZhenXiao

2019, 35(8): 1842-1846. DOI: 10.3969/j.issn.1001-5256.2019.08.043

Abstract(1089)

PDF (1944KB)(218) Cited By (2)

Abstract:
Hepatic fibrosis refers to the pathological process of abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Hepatic fibrosis is observed in the whole process of liver injury repair and healing, and long-term chronic injury factors may induce the progression ...

Role of the Numb gene in the progression of liver fibrosis

Xu Wen, Xu YanNan, Liu Ping, Mu YongPing

2019, 35(8): 1847-1850. DOI: 10.3969/j.issn.1001-5256.2019.08.044

Abstract(1062)

PDF (1936KB)(218) Cited By (3)

Abstract:
Liver fibrosis is the response of the body to wound repair, and it is the only way for various chronic liver diseases to develop into liver cirrhosis. At present, there is still no chemical or biological drugs for blocking or reversing liver fibrosis. Liver fibrosis has a complex pathogenesis, which...

Early diagnosis of spontaneous bacterial peritonitis in liver cirrhosis

Zhang YaNan, Jiang Chang, Xu Ying, Gao YanHang

2019, 35(8): 1851-1853. DOI: 10.3969/j.issn.1001-5256.2019.08.045

Abstract(1196)

PDF (1914KB)(249) Cited By (30)

Abstract:
Spontaneous bacterial peritonitis is a common complication of liver cirrhosis, and once it occurs, the disease might progress quickly to liver failure and multiple organ failure, which has a high mortality rate. It has been documented that delayed diagnosis of peritonitis is an important factor for ...

Association between intestinal barrier and bacterial translocation in patients with liver cirrhosis

Li PeiBo, Qin FanBo, Gong JianPing

2019, 35(8): 1854-1857. DOI: 10.3969/j.issn.1001-5256.2019.08.046

Abstract(1159)

PDF (1922KB)(258) Cited By (21)

Abstract:
Decompensated liver cirrhosis has various life-threatening complications such as spontaneous bacterial peritonitis, hepatic encephalopathy, and sepsis, and the development of such complications is closely associated with bacterial translocation. Pathological bacterial translocation in patients with ...

Current status and perspectives of multimodality therapy for hepatocellular carcinoma

Tan YunHua, Shang YangYang, Zhang Tao, Li JianBo, Zheng MingYou

2019, 35(8): 1858-1860. DOI: 10.3969/j.issn.1001-5256.2019.08.047

Abstract(1272)

PDF (1916KB)(383) Cited By (27)

Abstract:
Hepatocellular carcinoma (HCC) has high morbidity and mortality rates worldwide, and due to the complexity of the development of HCC, the management strategy for HCC has not been completely unified. During the past decade, the treatment of HCC has developed into a multidisciplinary and multimodality...

Current status of the research on psychosocial factors in patients with nonalcoholic fatty liver disease

He ShiHua, Hu GuoXin

2019, 35(8): 1861-1864. DOI: 10.3969/j.issn.1001-5256.2019.08.048

Abstract(1015)

PDF (1919KB)(230) Cited By (4)

Abstract:
Unhealthy dietary habits and a sedentary lifestyle have led to a significant increase in the prevalence rate of non-alcoholic fatty liver disease (NAFLD) in children, adolescents, and adults. In recent years, the biological-psychological-social medical pattern has attracted more and more attention, ...

Current status of research on mouse models of nonalcoholic fatty liver fibrosis

Wang Xin, Hu YiYang, Feng Qin

2019, 35(8): 1865-1869. DOI: 10.3969/j.issn.1001-5256.2019.08.049

Abstract(1285)

PDF (1942KB)(279) Cited By (4)

Abstract:

At present, nonalcoholic fatty liver fibrosis is one of the highlights of the research on nonalcoholic fatty liver disease (NAFLD) , and there is an urgent need for exploring its pathogenesis and treatment drugs in clinical practice. Animal model is an important tool for basic research, and the mous...

Influencing factors for the prognosis of primary biliary cholangitis

Xu Li, Zheng YueQi, Shi Zhen, Chen YiYun, Shao HuiJiang, Chen JianJie

2019, 35(8): 1870-1873. DOI: 10.3969/j.issn.1001-5256.2019.08.050

Abstract(1628)

PDF (2098KB)(271) Cited By (11)

Abstract:
Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune disease and may progress to liver fibrosis, liver cirrhosis, and even end-stage liver disease without timely and effective treatment. The main purpose of PBC treatment is to prevent the development of end-stage liver disease and i...

Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

Wang WeiZhao, Xiang XiaoXing

2019, 35(8): 1874-1877. DOI: 10.3969/j.issn.1001-5256.2019.08.051

Abstract(1729)

PDF (1928KB)(249) Cited By (26)

Abstract:
Autoimmune hepatitis (AIH) is a chronic autoimmune disease in the liver, with major clinical manifestations of positive autoantibody, abnormal elevation of aminotransferases, and hypergammaglobulinemia. Current studies have shown that regulatory T (Treg) /T helper17 (Th17) and T helper 1 (Th1) /T he...

Value of indocyanine green clearance test in assessing liver reserve function

Zhang MingMing, Zhang LingYi

2019, 35(8): 1878-1881. DOI: 10.3969/j.issn.1001-5256.2019.08.052

Abstract(1901)

PDF (1932KB)(317) Cited By (16)

Abstract:
Basic liver functions can guarantee substance metabolism necessary for the body, and the liver itself has the ability of self-healing and self-regeneration. Routine liver function tests cannot fully reflect the potential of liver parenchyma, i. e., the actual status of liver reserve function. Indocy...

Research advances in the role of protective autophagy in regulating vasculogenic mimicry formation in malignancies such as cholangiocarcinoma

Wu YanBin, Wang XueWen, Niu HongKai, Cheng Yu

2019, 35(8): 1882-1884. DOI: 10.3969/j.issn.1001-5256.2019.08.053

Abstract(1169)

PDF (1914KB)(219) Cited By (3)

Abstract:
Cholangiocarcinoma is a primary malignant tumor derived from the epithelium of the intrahepatic and extrahepatic bile ducts, and vasculogenic mimicry induced by hypoxia and lack of nutrition is a key factor for malignant proliferation, recurrence, and metastasis of cholangiocarcinoma. Previous studi...

Role of long non-coding RNA in the development and progression of cholangiocarcinoma

Zhang ShiLong, Gao WeiDong, Feng ZanJie, Duan YuLing, Fan GuoXin, Peng CiJun

2019, 35(8): 1885-1888. DOI: 10.3969/j.issn.1001-5256.2019.08.054

Abstract(1235)

PDF (1923KB)(232) Cited By (8)

Abstract:
Cholangiocarcinoma is a malignant tumor originating from the epithelial cells of the bile duct, and its incidence and mortality rates keep increasing year by year. Unknown pathogenesis of this disease has led to the difficulties in early diagnosis and treatment. With the development of genetic engin...

2019 Vol. 35, No. 8

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2019 Vol. 35, No. 8

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International Database

New media cluster

Media cluster

Open access

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