Objective To present the computed tomography (CT) findings and associated pathological features of eight cases of primary hepatic angiosarcoma (PHA) .Methods All cases were confirmed by pathology.After a CT scan of the upper abdomen, all cases of PHA underwent enhanced scans in the arterial phase, portal venous phase, and delayed phase to observe the CT manifestations.The surgical specimens were subjected to conventional hematoxylin- eosin staining and immunohistochemistry and observed under a microscope.Results Of all patients, 5 cases were massive type, 2 cases were mixed type, and 1 case was multiple nodule type.CT scans revealed inhomogeneous low- density lesions, with necrosis of even lower density in the central part.In 4 cases of massive type, scattered high- density small pieces were observed in low- density areas;in one case of mixed type, high- density nodules were observed on the edge of mass.There were 7 cases of peripheral nodular irregular enhancement in the arterial phase, including 1 case with flocculent central enhancement and another with no enhancement.Lesions remained enhanced in the portal venous and delayed phases, but 1 case had no enhancement.Five in 9 lesions had sharp edges in the arterial and portal venous phases, with“sharpen rim perpendicular to pleura”signs at the boundaries with the surrounding normal liver tissue.The outer edges of 7 lesions were found to have“pseudocapsules”in the portal venous phase.Conclusion CT scans showed a large hypodense lesion with irregular necrotic areas or scattered hemorrhage in PHA patients, whist enhanced scans showed a progressive filling and necrotic area in the central part.There could be“sharpen rim perpendicular to pleura”and“pseudocapsule”signs at the edge.It might be helpful to improve the diagnosis through the above characteristic features.
[1]MOLINA E, HERNANDEZ A.Clinical manifestations of primary hepatic-angiosarcoma[J].Dig Dis Sci, 2003, 48 (4) :677-682.
|
[2]YANG WC, QIU SJ.Multi-slice CT diagnosis of primary hepatic angiosarcoma[J].Radiol Practice, 2012, 27 (7) :771-774. (in Chinese) 杨伟聪, 邱士军.原发性肝血管肉瘤的多层螺旋CT表现[J].放射实践学, 2012, 27 (7) :771-774.
|
[3] ZHANG L, CHENG HY, XIE CY, et al.MRI findings of primary hepatic angiosarcoma[J].J Pract Radiol, 2010, 26 (9) :1380-1382. (in Chinese) 张亮, 程红岩, 谢朝阳, 等.原发性肝脏血管肉瘤MRI表现[J].实用放射学杂志, 2010, 26 (9) :1380-1382.
|
[4] ZHOU ML, YAN FH, YE F, et al.Images of primary hepatic angiosarcomas[J].Chin J Hepatol, 2008, 16 (2) :136-137. (in Chinese) 周梅玲, 严福华, 叶芳, 等.原发性肝脏血管肉瘤影像学表现[J].中华肝脏病杂志, 2008, 16 (2) :136-137.
|
[5]XU Y, CHEN YP, WANG Q, et al.Helical CT appearances of primary hepatic angiosarcoma[J].J Clin Radiol, 2011, 30 (9) :1306-1309. (in Chinese) 徐嬿, 陈燕萍, 王琦, 等.原发性肝脏血管肉瘤的螺旋CT表现[J].临床放射学杂志, 2011, 30 (9) :1306-1309.
|
[6]KOYAMA T, FLETCHER JG, JOHNSON CD, et al.Primary hepatic angiosarcoma:findings at CT and MR imaging[J].Radiology, 2002, 222 (3) :667-673.
|
[7]BUETOW PC, BUCK JL, ROS PR, et al.Malignant vascular tumors of the liver:radiologic-pathologic correlation[J].Radiographics, 1994, 14 (1) :153-166.
|
[8]WANG JP, LENG JY, CUI YQ, et al.The diagnosis and clinical value of multi-slice spiral CT in children with common liver tumor[J].J Clin Hepatol, 2011, 27 (7) :719. (in Chinese) 王继萍, 冷吉燕, 崔亚琼, 等.多层螺旋CT对小儿常见肝脏肿瘤的诊断特征及临床价值[J].临床肝胆病杂志, 2011, 27 (7) :719.
|
[9]WHITE PG, ADAMS H, SMITH PM.The computed tomographic appearances of angiosarcoma of the liver[J].Clin Radiol, 1993, 48 (5) :321-325.
|
[10]WANG AP, WEN CY.Recent perspectives in hepatocellular carcinoma (HCC) diagnosis and treatment[J].J Clin Hepatol, 2013, 29 (1) :32-35. (in Chinese) 王爱平, 温春阳.肝细胞癌诊治中的若干问题[J].临床肝胆病杂志, 2013, 29 (1) :32-35.
|
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