Effect of splenectomy plus pericardial devascularization on coagulation function in patients with cirrhotic portal hypertension

Objective To determine platelet count (PLT) , mean platelet volume (MPV) , and hemodynamic changes in patients with cirrhotic portal hypertension (CPH) post splenectomy plus pericardial devascularization (SPPD) , and to assess the surgical effect on coagulation function. Methods A retrospective analysis was performed on 83 CPH patients undergoing SPPD in our hospital from January 2008 to December 2012. Results Compared with preoperative levels, postoperative portal venous pressure decreased, blood flow was reduced, and portal vein diameter was significantly reduced; additionally, postoperative hepatic artery diameter was increased, and hepatic artery blood flow increased. Blood alanine aminotransferase, albumin, total protein, and fibrinogen levels, thrombin time, and MPV did not significantly change 30 days postoperatively versus 7 days preoperatively (P > 0. 05) ; the corresponding total bilirubin, activated partial thromboplastin time and prothrombin time relatively declined (P < 0. 05) , whereas PLT and prothrombin time activity increased (P < 0. 05) . There was a significant increase in PLT (P < 0. 05) but no significant change in MPV 30 days postoperatively versus 7 days preoperatively (P > 0. 05) .Conclusion SPPD can significantly improve liver functional reserve and coagulation function in patients with CPH.