Efficacy of adjuvant therapy with fenofibrate for primary biliary cirrhosis: a Meta-analysis

Objective To assess the efficacy of adjuvant therapy with fenofibrate for primary biliary cirrhosis( PBC). Methods CNKI,Wanfang Data,China Biology Medicine,Pub Med,Embase,and Cochrane library were searched for the pertinent literature of randomized controlled trials( RCTs) of adjuvant therapy with fenofibrate for PBC published up to December 31,2014. Data extraction and quality assessment were carried out,and the data were statistically analyzed by Stata10. 1 software. Respectively,for heterogeneity test. The fixed effect model is chosen for homogeneity,and the random effect model is chosen for heterogeneity. Results Six RCTs met the inclusion criteria. Treatment with fenofibrate was associated with significantly reduced levels of gamma- glutamyl transpeptidase,alanine aminotransferase,and alkaline phosphatase in PBC patients( SMD =- 1. 595,- 0. 447,and- 2. 125,respectively,all P < 0. 05). There were no significant changes in the levels of aspartate aminotransferase and total bilirubin after adjuvant therapy with fenofibrate( both P > 0. 05). Also,fenofibrate led to no significant improvement in immunoglobulin M( P > 0. 05). Conclusion Fenofibrate,which improves the indicators of liver function but leads to no changes in immunological indicators,appears to be an effective adjuvant therapy in PBC patients. There is a critical need for more large-scale,multi- center,high- quality RCTs to determine its effect on liver disease- related morbidity and mortality.