Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis

Jiao ShuHua; Liu PengLiang; Wen YanHui

doi:10.3969/j.issn.1001-5256.2016.01.025

Volume 32 Issue 1

Jan. 2016

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2016 > 32(1): 131-134

PDF( 1498 KB)

Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2016.01.025

Department of Gastroenterology,Fourth Affiliated Hospital of China Medical University

Received Date: 2015-06-01
Published Date: 2016-01-20

Abstract

Abstract

Objective To evaluate the value of combined determination of various indices in the clinical diagnosis of acute pancreatitis( AP) through dynamic measurements of the levels of peripheral serum C- reactive protein( CRP),lipase( LPS),interleukin- 1β( IL-1β),and intercellular adhesion molecule 1( ICAM- 1),as well as changes in their levels,in patients with AP. Methods A total of 86 patients with AP who were treated in Fourth Affiliated Hospital of China Medical University from January 2010 to December 2012 were selected,among whom there were 39 patients with severe acute pancreatitis( SAP) and 47 patients with mild acute pancreatitis( MAP). Serum samples were collected from these patients on days 1,3,5,and 7 of admission. Twelve healthy subjects were selected as controls. Enzyme- linked immunosorbent assay was applied to measure the levels of CRP,IL- 1β,and ICAM- 1,and the dry slides method was applied to measure the concentration of serum LPS. The t test and χ2test were applied for comparison of continuous data and categorical data between groups,respectively. Results On day 1 of admission,the patients in MAP group had significantly higher levels of CRP,IL- 1β,and LPS than those in control group( t =- 74. 126,- 60. 135,and- 364. 153,respectively; all P < 0. 001); on day 1 of admission,the patients in SAP group had significantly higher levels of CRP,ICAM- 1,IL- 1β,and LPS than those in control group( t =- 121. 355,- 25. 728,- 89. 422,and- 415. 840,respectively; all P < 0. 001). The peak concentration of each index appeared on day 1 or 3 of admission,and decreased progressively in the course of therapy. The patients in SAP group had significantly higher levels of serum CRP,LPS,IL- 1β,and ICAM- 1 than those in MAP group( all P < 0. 05). Conclusion Combined determination of serum CRP,LPS,IL- 1β,and ICAM- 1levels has a certain clinical value in early identification of severity of AP.
- pancreatitis,
- C-reactive protein,
- lipase,
- interleukin-1beta,
- intercellular adhesion molecule-1,
- diagnosis

FullText(HTML)

References(15)

References

[1]Pancreas Study Group,Chinese Society of Gastroenterology,Chinese Medical Association,Editorial Board of Chinese Journal of Pancreatology,Editorial Board of Chinese Journal of Digestion.Chinese guidelines for the management of acute pancreatitis(Shanghai,2013)[J].J Clin Hepatol,2013,29(9):656-660.(in Chinese)中华医学会消化病学分会胰腺疾病学组,《中华胰腺病杂志》编辑委员会,《中华消化杂志》编辑委员会.中国急性胰腺炎诊治指南(2013,上海)[J].临床肝胆病杂志,2013,29(9):656-660.

[2]INCE AT,BAYSAL B.Pathophysiology,classification and available guidelines of acute pancreatitis[J].Turk J Gastroenterol,2014,25(4):351-357.

[3]WAN B,FU H,YIN J,XU F.Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis:a randomized controlled trial[J].Scand J Gastroenterol,2014,49(11):1375-1384.

[4]HUANG Q,LI M,YANG WW,et al.Analysis on the efficacy of low molecular weight heparin in treatment of severe acute pancreatitis[J].J Clin Exp Med,2013,12(18):1459-1461.(in Chinese)黄强,李宓,杨薇薇,等.低分子肝素治疗重症急性胰腺炎的疗效分析[J].临床和实验医学杂志,2013,12(18):1459-1461.

[5]LI XJ,CHEN YZ,XU LQ.Combined detection of serum amylase and lipase in the diagnosis of acute pancreatitis[J].Int J Lab Med,2011,32(21):2503-2504.(in Chinese)李锡敬,陈艳芝,许柳芹.血清淀粉酶和脂肪酶联合检测在急性胰腺炎诊断中的应用[J].国际检验医学杂志,2011,32(21):2503-2504.

[6]FENG GM,DU R.Combined dynamic detection of serum lipase and amylase in the diagnosis of acute pancreatitis[J].Med J Chin People's Health,2012,24(9):1038-1040.(in Chinese)丰光明,杜戎.联合动态检测血清脂肪酶和淀粉酶在急性胰腺炎诊断中作用[J].中国民康医学,2012,24(9):1038-1040.

[7]HOFMEYR S,MEYER C,WARREN BL.Serum lipase should be the laboratory test of choice for suspected acute pancreatitis[J].S Afr J Surg,2014,52(3):72-75.

[8]VOLZ KA,McG ILLICUDDY DC,HOROWITZ GL,et al.Eliminating amylase testing from the evaluation of pancreatitis in emergency department[J].West J Emerg Med,2010,11(4):344-347.

[9]KEDIA S,DHINGRA R,GARG PK.Recurrent acute pancreatitis:an approach to diagnosis and management[J].Trop Gastroenterol,2013,34(3):123-135.

[10]ZHAO H.ICAM-1 and acute pancreatitis[J].Surg Foreign Med Sci,2002,29(6):346-349.(in Chinese)赵华.ICAM-1与急性胰腺炎[J].国外医学:外科学分册,2002,29(6):346-349.

[11]KAPLAN M,YAZGAN Y,TANOGLU A,et al.Effectiveness of interleukin-1 receptor antagonist(Anakinra)on cerulein-induced experimental acute pancreatitis in rats[J].Scand J Gastroenterol,2014,49(9):1124-1130.

[12]WANG XY,TANG QQ,ZHANG JL,et al.Effect of SB203580 on pathologic change of pancreatic tissue and expression of TNF-αand IL-1βin rats with severe acute pancreatitis[J].Eur Rev Med Pharmacol Sci,2014,18(3):338-343.

[13]SHA T,YI JH.The diagnostic value of C-reaction protein in acute pancreatitis[J].Lab Med Clin,2013,10(8):962-964.(in Chinese)沙涛,易金宏.C-反应蛋白对急性胰腺炎的诊断价值[J].检验医学与临床,2013,10(8):962-964.

[14]CHEN SZ,LI YX,LI J,et al.Evaluation of serum C-reaction protein in acute pancreatitis[J].Mod Med Health,2013,29(18):2799-2801.(in Chinese)陈善正,李宜雄,李窖,等.血清C-反应蛋白在急性胰腺炎病情评估中的意义[J].现代医药卫生,2013,29(18):2799-2801.

[15]YIN G,HU G,CANG X,et al.C-reactive protein:rethinking its role in evaluating the severity of hyperlipidemic acute pancreatitis[J].Pancreas,2014,43(8):1323-1328.

Relative Articles

[1]	Tong LIU, Shanzheng LI, Cheng ZHOU, Sutong LIU, Lihui ZHANG, Wenxia ZHAO. Study on the protective efect and mechanism of paeoniflorin on palmitic acid-induced HepG2 cells[J]. Journal of Clinical Hepatology, 2025, 41(3): 499-505. doi: 10.12449/JCH250316
[2]	Lai Xin, Zhou TaiCheng, Wei Jia. Association between HBV A1762T/G1764A double nucleotide substitution and liver diseases[J]. Journal of Clinical Hepatology, 2018, 34(9): 1990-1994. doi: 10.3969/j.issn.1001-5256.2018.09.034
[3]	Pang Ting, Xing HuiChun. Correlation between drug-resistance gene mutations and hepatocellular carcinoma in patients with hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2017, 33(1): 82-86. doi: 10.3969/j.issn.1001-5256.2017.01.017
[4]	Du SenRong, Mao XiaoRong, Xiao Ping, Chen Hong. Effects of PARP-1 inhibitors AG-014699 and AZD2281 on proliferation and apoptosis of human hepatoma cell line HepG2[J]. Journal of Clinical Hepatology, 2015, 31(6): 943-946. doi: 10.3969/j.issn.1001-5256.2015.06.027
[5]	Wang LiPing, Han FangZheng, Li ChunYang, Yan Mei, Zhang YanChao, Yan XueBing. Evaluation of adefovir primary resistance and adefovir repulsive mutations of the HBV DNA P gene in chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2012, 28(8): 606-608.
[6]	Jin WenWen, Xin YongNing, Dong QuanJiang, Zhao ShouFeng, Yu XinJuan, Jiang Man, Xu Jing, Xuan ShiYing. The preliminary study on the relationship between hepatitis B virus BCP gene mutations and HBV-related primary hepatocellular carcinoma in Qingdao[J]. Journal of Clinical Hepatology, 2012, 28(2): 130-134.
[7]	Yang YanLin, Xiao Ping, Gao Peng, Wang LiMing, Wei XiSheng, He Qiang, Zhou Ping. Distribution of HBV genotypes and YMDD mutations in E antigen-positive patients[J]. Journal of Clinical Hepatology, 2012, 28(6): 428-430.
[8]	Hong YuBo, Zhang Ting, Sun LiGuang. Association between IL-2 +114 (G/T) polymorphism and susceptibility to hepatitis B, cirrhosis, and hepatocellular carcinoma in Jilin province[J]. Journal of Clinical Hepatology, 2012, 28(12): 930-933.
[9]	Deng Le, Wen ZhiLi. Review of recent research progress in correlating HBV genotypes with efficacy of antiviral treatments[J]. Journal of Clinical Hepatology, 2012, 28(6): 469-473.
[10]	Zhang JianJun, Wu LiPing, Du RuiQing, Wang JianBin, Yao ZhanCheng, Yu GuiQin. Factors correlating with the liver inflammation grade ≥G2 in chronic HBV-infected patients with normal liver function[J]. Journal of Clinical Hepatology, 2012, 28(1): 35-38.
[11]	Liu JinPing, Liu YouDe, Guo YanMei, Yang ShaoPing, Lin Qing, Lin Ling. Clinical characteristics and distribution of hepatitis B virus genotypes in CHB patients in Yantai area[J]. Journal of Clinical Hepatology, 2011, 27(12): 1288-1290.
[12]	Zou XiaoJing, Jiang XueQiang, Tian DeYing. Role of DC-SIGN on the maturation and activation of dendritic cells in chronic hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2011, 27(2): 145-147+153.
[13]	Xiong QiXiang, Xiong LiJuan. Hepatitis B virus infection and DNA methylation in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2011, 27(8): 881-884.
[14]	Pan Lei, Wei Xin, Xie YuMei, Hao ChunQiu, Wang JiuPing, Jia ZhanSheng, Bai XueFan. Anti-viral therapy with pegylated interferon alpha-2a plus ribavirin in patients co-infected with HBV and HCV[J]. Journal of Clinical Hepatology, 2011, 27(1): 84-85+95.
[15]	Yuan JianGuo, Wang XinGuo, Cui Xia, Liu FengHua, Wang FengHua, Song JiKui, Zhao HongKui. The activation of rat hepatic stellate cells stimulated with hepatitis B virus in vitro[J]. Journal of Clinical Hepatology, 2011, 27(2): 163-165.
[16]	Xi HongLi, Liu FangFang, Yuan JiaYing, Yu YanYan. Significance and detection of IL-2、IL-4 and IFN-γ in PBMC from patients with hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2010, 26(6): 627-629.
[17]	Wang GuoQiang, Niu JuXia. The HBx protein mutation among different HBV genotypes[J]. Journal of Clinical Hepatology, 2010, 26(4): 392-394.
[18]	Shi YanMei, Lan YingHua, Dan Lei, Zhou Jin, Li YongGuo. The relationship between of hematopoietic stem cells and hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2010, 26(4): 377-380.
[19]	Xie DeSheng, Zhang QingBo, Chen ChangXing, Huang JianFang, Ma Jin, Huang HaiBin, Du Yao. The relationship between HBV gene mutation in HBV infected family and HLA class Ⅱ alleles[J]. Journal of Clinical Hepatology, 2010, 26(4): 383-386.
[20]	Xu ZhengJu, Yang Hong, Zhang QiHua, Chen XianLi, Li ShuQing, Wang ChongGuo. Study on the relationship between hepatitis B virus genotypes and effect of lamivudine therapy.[J]. Journal of Clinical Hepatology, 2005, 21(3): 157-159.

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	中国抗癌协会肿瘤消融治疗专业委员会，中国临床肿瘤学会肿瘤消融治疗专家委员会，中国医师协会介入医师分会介入围手术学组. 复合式冷热消融治疗肝肿瘤围手术期管理专家共识. 中华内科杂志. 2025(02): 110-118 .
2.	温钊，臧铁柱，宋晓改，张炫，江艳丽. 射频消融治疗包膜下与非包膜下早期肝细胞癌患者的远期预后. 河南医学研究. 2023(15): 2738-2744 .

Other cited types(0)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (2414) PDF downloads(424)

Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2016.01.025