中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2016.01.025
  • Received Date: 2015-06-01
  • Published Date: 2016-01-20
  • Objective To evaluate the value of combined determination of various indices in the clinical diagnosis of acute pancreatitis( AP) through dynamic measurements of the levels of peripheral serum C- reactive protein( CRP),lipase( LPS),interleukin- 1β( IL-1β),and intercellular adhesion molecule 1( ICAM- 1),as well as changes in their levels,in patients with AP. Methods A total of 86 patients with AP who were treated in Fourth Affiliated Hospital of China Medical University from January 2010 to December 2012 were selected,among whom there were 39 patients with severe acute pancreatitis( SAP) and 47 patients with mild acute pancreatitis( MAP). Serum samples were collected from these patients on days 1,3,5,and 7 of admission. Twelve healthy subjects were selected as controls. Enzyme- linked immunosorbent assay was applied to measure the levels of CRP,IL- 1β,and ICAM- 1,and the dry slides method was applied to measure the concentration of serum LPS. The t test and χ2test were applied for comparison of continuous data and categorical data between groups,respectively. Results On day 1 of admission,the patients in MAP group had significantly higher levels of CRP,IL- 1β,and LPS than those in control group( t =- 74. 126,- 60. 135,and- 364. 153,respectively; all P < 0. 001); on day 1 of admission,the patients in SAP group had significantly higher levels of CRP,ICAM- 1,IL- 1β,and LPS than those in control group( t =- 121. 355,- 25. 728,- 89. 422,and- 415. 840,respectively; all P < 0. 001). The peak concentration of each index appeared on day 1 or 3 of admission,and decreased progressively in the course of therapy. The patients in SAP group had significantly higher levels of serum CRP,LPS,IL- 1β,and ICAM- 1 than those in MAP group( all P < 0. 05). Conclusion Combined determination of serum CRP,LPS,IL- 1β,and ICAM- 1levels has a certain clinical value in early identification of severity of AP.

     

  • [1]Pancreas Study Group,Chinese Society of Gastroenterology,Chinese Medical Association,Editorial Board of Chinese Journal of Pancreatology,Editorial Board of Chinese Journal of Digestion.Chinese guidelines for the management of acute pancreatitis(Shanghai,2013)[J].J Clin Hepatol,2013,29(9):656-660.(in Chinese)中华医学会消化病学分会胰腺疾病学组,《中华胰腺病杂志》编辑委员会,《中华消化杂志》编辑委员会.中国急性胰腺炎诊治指南(2013,上海)[J].临床肝胆病杂志,2013,29(9):656-660.
    [2]INCE AT,BAYSAL B.Pathophysiology,classification and available guidelines of acute pancreatitis[J].Turk J Gastroenterol,2014,25(4):351-357.
    [3]WAN B,FU H,YIN J,XU F.Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis:a randomized controlled trial[J].Scand J Gastroenterol,2014,49(11):1375-1384.
    [4]HUANG Q,LI M,YANG WW,et al.Analysis on the efficacy of low molecular weight heparin in treatment of severe acute pancreatitis[J].J Clin Exp Med,2013,12(18):1459-1461.(in Chinese)黄强,李宓,杨薇薇,等.低分子肝素治疗重症急性胰腺炎的疗效分析[J].临床和实验医学杂志,2013,12(18):1459-1461.
    [5]LI XJ,CHEN YZ,XU LQ.Combined detection of serum amylase and lipase in the diagnosis of acute pancreatitis[J].Int J Lab Med,2011,32(21):2503-2504.(in Chinese)李锡敬,陈艳芝,许柳芹.血清淀粉酶和脂肪酶联合检测在急性胰腺炎诊断中的应用[J].国际检验医学杂志,2011,32(21):2503-2504.
    [6]FENG GM,DU R.Combined dynamic detection of serum lipase and amylase in the diagnosis of acute pancreatitis[J].Med J Chin People's Health,2012,24(9):1038-1040.(in Chinese)丰光明,杜戎.联合动态检测血清脂肪酶和淀粉酶在急性胰腺炎诊断中作用[J].中国民康医学,2012,24(9):1038-1040.
    [7]HOFMEYR S,MEYER C,WARREN BL.Serum lipase should be the laboratory test of choice for suspected acute pancreatitis[J].S Afr J Surg,2014,52(3):72-75.
    [8]VOLZ KA,McG ILLICUDDY DC,HOROWITZ GL,et al.Eliminating amylase testing from the evaluation of pancreatitis in emergency department[J].West J Emerg Med,2010,11(4):344-347.
    [9]KEDIA S,DHINGRA R,GARG PK.Recurrent acute pancreatitis:an approach to diagnosis and management[J].Trop Gastroenterol,2013,34(3):123-135.
    [10]ZHAO H.ICAM-1 and acute pancreatitis[J].Surg Foreign Med Sci,2002,29(6):346-349.(in Chinese)赵华.ICAM-1与急性胰腺炎[J].国外医学:外科学分册,2002,29(6):346-349.
    [11]KAPLAN M,YAZGAN Y,TANOGLU A,et al.Effectiveness of interleukin-1 receptor antagonist(Anakinra)on cerulein-induced experimental acute pancreatitis in rats[J].Scand J Gastroenterol,2014,49(9):1124-1130.
    [12]WANG XY,TANG QQ,ZHANG JL,et al.Effect of SB203580 on pathologic change of pancreatic tissue and expression of TNF-αand IL-1βin rats with severe acute pancreatitis[J].Eur Rev Med Pharmacol Sci,2014,18(3):338-343.
    [13]SHA T,YI JH.The diagnostic value of C-reaction protein in acute pancreatitis[J].Lab Med Clin,2013,10(8):962-964.(in Chinese)沙涛,易金宏.C-反应蛋白对急性胰腺炎的诊断价值[J].检验医学与临床,2013,10(8):962-964.
    [14]CHEN SZ,LI YX,LI J,et al.Evaluation of serum C-reaction protein in acute pancreatitis[J].Mod Med Health,2013,29(18):2799-2801.(in Chinese)陈善正,李宜雄,李窖,等.血清C-反应蛋白在急性胰腺炎病情评估中的意义[J].现代医药卫生,2013,29(18):2799-2801.
    [15]YIN G,HU G,CANG X,et al.C-reactive protein:rethinking its role in evaluating the severity of hyperlipidemic acute pancreatitis[J].Pancreas,2014,43(8):1323-1328.
  • Cited by

    Periodical cited type(11)

    1. 肖春桃,李贤秋,甘佩灵,潘潇,周贤. 基于倾向性评分匹配分析门静脉血栓对肝硬化患者预后的影响. 临床肝胆病杂志. 2021(08): 1829-1835 . 本站查看
    2. 王彤,牛焕章,杜廷伟,魏乐群. 乙型肝炎肝硬化患者门静脉血栓发生的影响因素及抗凝治疗效果研究. 深圳中西医结合杂志. 2021(17): 134-136 .
    3. 姜炅,袁佳,史海涛,戴社教. 血清ALT、AST联合NFS评分对非酒精性脂肪性肝硬化患者食管胃底静脉曲张严重程度的评估价值. 中西医结合肝病杂志. 2020(04): 314-317 .
    4. 李英,高磊,胡扬喜,胡德升. 低分子肝素钙联合右旋糖酐在肝硬化门静脉高压症术后静脉血栓形成预防中的应用. 肝脏. 2019(07): 788-790 .
    5. 吕靖,董思思,顾宏图,赵长青,刘成海. 肝硬化并发门静脉血栓的危险因素及中医证候特点. 临床肝胆病杂志. 2019(10): 2210-2213 . 本站查看
    6. 陈仙艳. 肝硬化合并上消化道出血患者门静脉血栓形成危险因素分析与护理. 护理实践与研究. 2019(18): 13-15 .
    7. 牟思玉,杨哲,吴力群,邱轩,郭珈铭. 肝硬化门静脉高压脾切除术后门静脉血栓形成的预测因素分析. 临床肝胆病杂志. 2018(01): 106-111 . 本站查看
    8. 张津瑜,陈文显,沈华,王雁,张国雷,慎华平,吴万波,魏云海. 大鼠门静脉系统血栓形成模型的建立和观察. 中国普通外科杂志. 2018(06): 724-731 .
    9. 邢文立,李谦. 重症监护病房肝病患者的血栓预防与出血控制. 临床肝胆病杂志. 2018(10): 2237-2240 . 本站查看
    10. 李志州,向俊峰,周威,唐亮. 探讨门脉高压及外伤性脾破裂行脾切除术后血小板升高及门静脉血栓形成情况. 肝胆外科杂志. 2018(04): 280-282 .
    11. 王士浩,张宏伟. 肝硬化合并门静脉血栓形成危险因素的病例对照研究. 中国中西医结合消化杂志. 2017(11): 867-870 .

    Other cited types(12)

  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2419) PDF downloads(424) Cited by(23)
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return