Objective To investigate the change in the serum level of complement C5 a after obstruction removal and its correlation with the serum levels of liver fibrosis markers in patients with obstructive jaundice. Methods A total of 164 patients with obstructive jaundice who underwent endoscopic retrograde cholangiopancreatography and obstruction removal in our hospital from June 2012 to June 2014 were enrolled,and 20 healthy adults were enrolled as the control group. The serum levels of complement C5 a and four liver fibrosis markers,type Ⅳcollagen( ⅣP),pre- type Ⅲ collagen( PⅢP),laminin( LN),and hyaluronic acid( HA),were measured. The t- test was applied for comparison between groups,and linear correlation analysis was applied for correlation analysis. Results Compared with the healthy controls,the patients with obstructive jaundice had a significantly higher serum level of complement C5a( 89. 7 ± 30. 2 vs 62. 2 ± 21. 1 ng / L;t = 2. 213,P = 0. 016),and the serum level of complement C5 a was closely related to the course of obstruction( r = 0. 954,P = 0. 003).The serum level of complement C5 a decreased significantly after obstruction removal( 66. 2 ± 26. 3 ng / L; t = 1. 998,P = 0. 021). Before obstruction removal,the serum level of complement C5 a increased synchronously with those of ⅣP( r = 0. 976,P < 0. 001),PⅢP( r =0. 972,P < 0. 001),LN( r = 0. 915,P = 0. 039),and HA( r = 0. 962,P = 0. 002); after obstruction removal,the serum level of complement C5 a decreased synchronously with those of ⅣP( r = 0. 965,P = 0. 001),PⅢP( r = 0. 912,P = 0. 003),and HA( r = 0. 875,P =0. 023). Conclusion Complement C5 a may be involved in the development of liver fibrosis induced by obstructive jaundice.
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