A prognostic analysis of laparoscopic versus radical cholecystectomy for T1b unsuspected gallbladder carcinoma

Objective To investigate the surgical treatment and prognosis of T1 b unsuspected gallbladder carcinoma( UGC). Methods Twenty- two patients with T1 b UGC admitted to our hospital were enrolled as subjects. The information on clinical pathology,radiological examination,laboratory tests,surgical treatment,and postoperative follow- up were analyzed in patients. The survival rate and recurrence were compared between patients treated with radical cholecystectomy and laparoscopic cholecystectomy. The Kaplan- Meier method was used to calculate survival rates,and the log- rank test was used for survival difference analysis. Comparison of categorical data was made by Fisher's exact test. Results The 1-,3-,and 5- year accumulative survival rates in all patients with T1 b UGC were 100%,89. 7%,and82. 8%,respectively; there was no significant difference in the 5- year accumulative survival rate between patients treated with laparoscopic cholecystectomy and radical cholecystectomy( 84. 6% vs 75. 0%,χ~2= 0. 000,P = 0. 991); two( 15. 4%) out of thirteen patients treated with laparoscopic cholecystectomy respectively; one( 12. 5%) out of eight patients treated with radical cholecystectomy had recurrence,there was no significant difference between the two groups( P > 0. 05). Conclusion Radical cholecystectomy is a superior therapy for T1 b UGC over laparoscopic cholecystectomy.