Prognostic value of several immune and inflammatory indices after curative-intent resection for intrahepatic cholangiocarcinoma

Bingqi MA; Huijuan MENG; Wei ZHANG; Xiaofeng DONG; Meng WANG; Jie DOU; Yuning WU; Shiping LI

doi:10.3969/j.issn.1001-5256.2022.09.021

Volume 38 Issue 9

Sep. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(9): 2061-2066

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Prognostic value of several immune and inflammatory indices after curative-intent resection for intrahepatic cholangiocarcinoma

DOI: 10.3969/j.issn.1001-5256.2022.09.021

1a.
Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, China
1b.
Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, China
2.
Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
3.
Department of Hepatobiliary, Pancreatic and Splenic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning 530021, China

Research funding:

Medical and Health Science and Technology Development Plan of Shandong Province (202004011537);

Weifang Science and Technology Development Program(Medical Science) (2020YX085);

Medical Research and Development Fund—Clinical and Basic Research Project (TB205004)

More Information

Corresponding author: LI Shiping, lishipingwyfy@126.com(ORCID: 0000-0001-9144-0180)
Received Date: 2022-03-06
Accepted Date: 2022-04-18
Published Date: 2022-09-20

Abstract

Abstract

Objective To investigate the value of different immune and inflammatory indices in predicting the survival outcome of patients with intrahepatic cholangiocarcinoma (ICC) after curative-intent resection. Methods A retrospective analysis was performed for the case data of 122 patients with ICC who underwent curative-intent resection in Affiliated Hospital of Weifang Medical University and Tianjin Medical University Cancer Institute and Hospital from January 2012 to December 2017 to analyze the correlation of neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation index (SII), prognostic inflammation index (PII), inflammation score (IS), and systemic inflammation score (SIS) with the disease-free survival (DFS) and overall survival of ICC patients after surgery, and the value of the above indices in predicting prognosis was evaluated. The chi-square test or the Fisher's exact test was used for comparison of categorical data between groups. The Kaplan-Meier method was used to plot survival curves, and the Log-rank test was used for comparison between groups; the Cox regression model was used for univariate and multivariate analyses, and hazard ratio (HR) and 95% confidence interval [CI] were calculated. Results The univariate survival analysis showed that NLR (HR=2.212, P=0.004), LMR (HR=0.403, P=0.012), PII (HR=3.013, P < 0.001), prognostic nutritional index (PNI) (HR=0.530, P=0.019), IS (HR=1.809, P=0.001), SII (HR=2.107, P=0.002), and SIS (HR=2.225, P < 0.001) were predictive factors for postoperative DFS of patients with ICC, and NLR (HR=2.416, P=0.009), LMR (HR=0.297, P=0.008), PII (HR=3.288, P < 0.001), PNI (HR=0.292, P=0.003), IS (HR=2.048, P=0.002), SII (HR=1.839, P=0.049), and SIS (HR=2.335, P < 0.001) were predictive factors for postoperative OS of patients with ICC. The multivariate survival analysis showed that high levels of PII (HR=2.146, P=0.035) and SIS (HR=2.511, P < 0.001) were independent influencing factors for postoperative DFS of ICC patients, and high levels of PII (HR=2.981, P=0.009), PNI (HR=0.261, P=0.002), and SIS (HR=2.294, P=0.010) were independent influencing factors for postoperative OS. The patients with a high level of PII tended to have advanced tumor T stage (χ²=8.777, P=0.003) and M stage (P=0.029), and the patients with high-grade SIS tended to have advanced N stage (χ²=9.985, P=0.030) and M stage (χ²=8.574, P=0.012). Conclusion Among the various inflammation indices, PII and SIS are recommended for preoperative stratification and prediction of the outcome of ICC patients after curative-intent resection.
- Bile Duct Neoplasms,
- Bile Ducts, Intrahepatic,
- Prognosis,
- Forecasting

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References(15)

References

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Prognostic value of several immune and inflammatory indices after curative-intent resection for intrahepatic cholangiocarcinoma

DOI: 10.3969/j.issn.1001-5256.2022.09.021