Risk factors for long-term complications after endoscopic sphincterotomy for benign biliary and pancreatic diseases

Objective To investigate the risk factors for long- term complications after endoscopic sphincterotomy( EST) for benign biliary and pancreatic diseases. Methods The follow- up data of the patients who underwent EST in Department of Gastroenterology,The First Affiliated Hospital of Shenzhen University,from July 2008 to June 2013 were analyzed retrospectively,and the risk factors for long- term complications after EST were investigated. The chi- square test was applied for comparision of categorical data betwee groups. The Kaplan-Meier method was applied to analyze the cumulative incidence of complications,and the univariate and multivariate logistic regression analyses were applied to investigate the risk factors for long- term complications. Results The patients were followed up for 4- 57 months,and the mean follow- up time was 30. 9 ± 12. 1 months. The cumulative incidence of long- term complications after EST was 9. 9%( 18 /182),and these complications included recurrent common bile duct stones( n = 9),recurrent cholangitis( n = 6),acute cholecystitis( n = 2),and biliary stricture( n = 1). There were significant differences between the two groups in diameter of common biledute,pneumobilia,and juxtapapillary diverticulum( all P < 0. 05). The multivariate logistic regression analysis showed that diameter of common bile duct ≥15 mm( OR = 4. 82,95% CI: 1. 08- 21. 55,P = 0. 040) and pneumobilia( OR = 6. 19,95% CI: 1. 23- 31. 23,P = 0. 027) were the risk factors for long- term complications after EST. Conclusion The incidence of long- term complications after EST for benign biliary and pancreatic diseases is low,and diameter of common bile duct ≥15 mm and pneumobilia are the risk factors for long- term complications after EST.